Results 181 to 190 of about 382,907 (311)

Virus Biomimetic-Delivery Systems for the Production of Vaccines. [PDF]

Biomimetics (Basel)
Barbinta-Patrascu ME, Negut I, Bita B.
europepmc   +1 more source

KCNJ2 is Required for NLRP3 Inflammasome Activation That Drives Allergic Airway Inflammation and Remodeling

Advanced Science, EarlyView.
This study aims to evaluate the impact of the potassium channel KCNJ2 on asthma development. KCNJ2 promotes NLRP3 inflammasome activation through both Ca2+ influx and K+ efflux in airway epithelial cells, which drives allergic airway inflammation and remodeling, suggesting a promising therapeutic target for asthma.
Yachao Cui, Shumei Wu, Yang Peng, Yiqi Liu, Li Che, Shiying Chen, Feng Zhang, Dajiang Qin, Shiyue Li, Pixin Ran, Wenguang Yin   +10 more
wiley   +1 more source

Engineering antibody-armed oncolytic viruses: design strategies, synergistic mechanisms, and clinical translation. [PDF]

Front Immunol
Kang X, Yang X, Wu H, Tong X, Wang S.
europepmc   +1 more source

HLA class-I-transgenic mice as model system to study MHC-restricted antigen recognition in man [PDF]

, 1990
A. McMichael, C. Botteron, Chamberlain J-W, Dill O, E. H. Weiss, Engelhard V H, F. Kievits, G. Brem, G. Riethmüller, G. Schliesser, Kievits F, Kievits K, Krimpenfort P, Le A-T, P. Ivanyi, Pohla H, Taurog J D, Thurau S R, Weiss E H, Weiss E H   +19 more
core   +1 more source

Discovery of an Adaptive Neuroimmune Response Driving Itch and Fast Tick Removal with Implications for Preventing Pathogen Transmission

Advanced Science, EarlyView.
Itch‐induced tick removal (IITR): An acquired neuroimmune mechanism, itch‐induced tick removal, develops after repeated tick exposure, mobilizing T cells and macrophages at the tick bite site to trigger a rapid scratching response that facilitates timely tick removal within a critical window that precedes the transmission of many tick‐borne pathogens ...
Johannes S. P. Doehl, Tiago D. Serafim, Serena Doh, Charles S. Grugan, Eva Iniguez, Luana Rogerio, Ronja Frigard, Ranadhir Dey, Pedro Cecilio, Xinglong Gu, Pang‐Yen Tseng, Aline da Silva Moreira, Mahnaz Minai, James Oristian, Hans Ackerman, Steven Brooks, Caroline Percopo, Siu‐Ping Ng, Derron A. Alves, Lucas Tirloni, Jennifer M. Anderson, Adriana Marques, Fabiano Oliveira, Shaden Kamhawi, Daniel E. Sonenshine, José M. C. Ribeiro, Mark Hoon, Jesus G. Valenzuela   +27 more
wiley   +1 more source

Universal broad-spectrum mucosal vaccine design for human coronaviruses inspired by artificial antibodies. [PDF]

NPJ Vaccines
Wu Y, Lu J, Fang L, Chen X, Zhao C, Zhang Z, Zhu X, Gao X, Li H, Yan Y, Shi J, Zhang J, Zhou P, Pan X.   +13 more
europepmc   +1 more source

A Functionally Conserved Enhancer is Critical for PGC1A Expression and Thermogenesis in Brown Fat

Advanced Science, EarlyView.
An evolutionarily conserved enhancer controls PGC1A expression and thermogenic activation in brown adipose tissue. Integrative multi‐omics analyses identify two BAT‐specific enhancers, with PGC1A‐En1 functioning as the dominant regulatory element that maintains thermogenic capacity across species.
Duo Su, Haosen Yang, Xiaokai Li, Tingting Jiang, Siyuan Zhan, Tao Zhong, Jiazhong Guo, Yan Wang, Li Li, Hongping Zhang, Linjie Wang   +10 more
wiley   +1 more source

Early rise in nasal secretory IgA associated with shorter duration of SARS-CoV-2 virus shedding in an acute infection cohort. [PDF]

Front Immunol
Brackett C, Zhang L, Do BTN, Baral S, Fisher LH, Hahn WO, Carnacchi AJ, Hilliard S, Li SS, Premkumar L, Greninger AL, Hyrien O, Seaton KE, Tomaras GD.   +13 more
europepmc   +1 more source

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

African Swine Fever: Vaccine Advancement and Major Gaps. [PDF]

Microorganisms
Wang L, Shi J.
europepmc   +1 more source