Results 201 to 210 of about 243,841 (269)

Single-Cell and Plasma Proteomics Do Not Differentiate Patients With and Without SARS-CoV-2 Antigenemia in Convalescence in a Cohort of 100 Patients. [PDF]

Open Forum Infect Dis
Pienkos S, Swank Z, Hamlin RE, Rao M, Grant P, Bonilla H, Jacobson K, Jagannathan P, Singh U, Walt DR, Subramanian A, Blish C.   +11 more
europepmc   +1 more source

ACSS2/AATF Drives Soluble FasL‐Mediated CD8+ T Cell Apoptosis in Pancreatic Neuroendocrine Tumors

Advanced Science, Volume 12, Issue 40, October 27, 2025.
This study unveils that ACSS2‐driven acetate metabolism fuels histone pan‐acetylation in pancreatic neuroendocrine tumors (PNETs), remodeling the epigenetic landscape. The ACSS2/AATF axis transcriptionally activates soluble FasL (sFasL), which engages Fas receptors on infiltrating CD8+ T cells to trigger caspase‐8/3‐mediated apoptosis.
Qin Dang, Ting Wang, Yan Wang, Zeng Ye, Borui Li, Xuan Pan, Zheng Li, Guixiong Fan, Desheng Jing, Junfeng Xu, Qiangsheng Hu, Shunrong Ji, Xiaowu Xu, Xianjun Yu, Yi Qin   +14 more
wiley   +1 more source

Recombinant Chimeric Virus-like Particles of Human Papillomavirus Produced by Distinct Cell Lineages: Potential as Prophylactic Nanovaccine and Therapeutic Drug Nanocarriers. [PDF]

Viruses
Oliveira CS, Sakauchi D, Sasaki ÉAK, Cianciarullo AM.   +3 more
europepmc   +1 more source

Spatial Transcriptomics Reveals Transcriptomic and Immune Microenvironment Reprogramming during Thyroid Carcinoma Dedifferentiation

Advanced Science, EarlyView.
Spatial transcriptomic analysis of Anaplastic thyroid carcinoma (ATC)‐differentiated thyroid carcinoma (DTC) coexisting tumors reveals that coexisting DTC regions with ATC‐like genomic alterations undergo sequential transcriptomic reprogramming and immune microenvironment remodeling, ultimately evolving into a full ATC pathological phenotype.
Kang Ning, Bu Zou, Yongchao Yu, Taonong Cai, Zhenyu Luo, Yu Guo, Yi Wu, Xiujiao Shen, Hao Li, Mengyuan Fang, Jian Bu, Han Hong, Zan Jiao, Tong Wu, Yulong Wang, Tianrun Liu, Weichao Chen, Wanming Hu, Mingjie Jiang, Ankui Yang   +19 more
wiley   +1 more source

Parallel evolution of the elite neutralizer phenotype in divergent HIV-1 clades. [PDF]

J Virol
Mesa KA, Li SW, Hutchinson JM, O'Rourke S, Alexander DL, Yu B, Shen X, Wrin T, Petropoulos CJ, Berman PW, Pogson GH.   +10 more
europepmc   +1 more source

FGF9–FGFR2 Signaling via Osteocytes‐Preosteoblasts Crosstalks to Mediate Mechanotransduction‐Driven Intramembranous Osteogenesis in the Underdeveloped Maxilla

Advanced Science, EarlyView.
This study identifies osteocyte‐derived FGF9 as a mechanosensitive factor that impairs osteogenesis in the underdeveloped maxilla by inducing FGFR2 nuclear translocation in preosteoblasts. Mechanical stimulation reduces FGF9 secretion, relieving its inhibitory effect. These findings reveal a novel osteocyte–preosteoblast FGF9–FGFR2 axis in craniofacial
Yiwen Zhou, Lili Chen, Miaomiao Han, Peixiang Zhu, Yanyi Wang, Xuanxuan Yu, Tingyu Reng, Huijuan Wang, Baochao Li, Caixia Zhang, Ziwei Huang, Shuang Lin, Guoyun Wang, Jie Ge, Baosheng Guo, Huang Li   +15 more
wiley   +1 more source

Immunogenicity of a trivalent haemorrhagic fever vaccine candidate against Sudan virus, Marburg virus and Lassa virus in an mpox vaccine. [PDF]

J Gen Virol
Pfranger M, Krause N, Asbach B, Meier J, Carnell G, Scheer L, Kalender A, Brenner D, Tonks P, Frost S, Wright E, Jordan I, Kennedy E, Hewson R, Blacklaws B, Chan A, Parthasarathy S, Dowall S, Carroll M, Sandig V, Fedosyuk S, Kinsley R, Heeney J, Wagner R.   +23 more
europepmc   +1 more source

A bivalent Mpox nanoparticle vaccine induces robust immune response and provides long-lasting protection against vaccinia virus challenge. [PDF]

Emerg Microbes Infect
Wang Y, Sun H, Zhou H, Yang W, Li S, Hao M, Chang H, Zhang Y, Wang Y, Chen J.   +9 more
europepmc   +1 more source

Antibody-Dependent Cellular Cytotoxicity Elicited by the Antibodies Against the E120R Protein of African Swine Fever Virus. [PDF]

Vaccines (Basel)
Chen S, Lan J, Lu Z, Li J, Ma C, Luo R, Fu Q, Sun Y, Wang T, Qiu HJ.   +9 more
europepmc   +1 more source