Results 11 to 20 of about 71,170 (384)

Antihistamine effects and safety of fexofenadine: a systematic review and Meta-analysis of randomized controlled trials

BMC Pharmacology and Toxicology, 2019
Background As a new generation antihistamine, fexofenadine has been widely used in allergic diseases. However, there is still a lack of collective evidence regarding the antihistamine effects and safety profiles of fexofenadine relative to other ...
Cheng-zhi Huang, Zhi-hui Jiang, Jian Wang, Yue Luo, Hua Peng   +4 more
doaj   +2 more sources

High occurrence of antihistamine resistance in patients with recurrent idiopathic angioedema

Clinical and Translational Allergy, 2019
Antihistamines are the most prescribed therapy in recurrent idiopathic angioedema, yet little is known about their efficacy. Herein, we report on clinical improvement with antihistamine therapy in 120 patients evaluating angioedema attack frequency.
Zonne L. M. Hofman, Nikki van West, C. Erik Hack, André C. Knulst, Coen Maas, Heike Röckmann   +5 more
doaj   +2 more sources

Fenebrutinib in H1 antihistamine-refractory chronic spontaneous urticaria: a randomized phase 2 trial

Nature Network Boston, 2021
Bruton’s tyrosine kinase (BTK) is crucial for FcεRI-mediated mast cell activation and essential for autoantibody production by B cells in chronic spontaneous urticaria (CSU).
M. Metz, G. Sussman, R. Gagnon, P. Staubach, Tonny Tanus, William H. Yang, Jeremy J. Lim, H. J. Clarke, J. Galanter, L. Chinn, Tom Chu, A. Teterina, T. Burgess, D. Haddon, Timothy T Lu, M. Maurer   +15 more
semanticscholar   +1 more source

Structural basis for recognition of antihistamine drug by human histamine receptor

Nature Communications, 2022
The histamine receptors belong to the G protein-coupled receptor (GPCR) superfamily, and play important roles in the regulation of histamine and other neurotransmitters in the central nervous system, as potential targets for the treatment of neurologic ...
Xueqian Peng, Linlin Yang, Zixuan Liu, Siyi Lou, Shiliu Mei, Meiling Li, Zhong Chen, Haitao Zhang   +7 more
semanticscholar   +1 more source

Antihistamine‐related deaths in England: Are the high safety profiles of antihistamines leading to their unsafe use?

British Journal of Clinical Pharmacology, 2021
Antihistamines are routinely taken to control allergic reactions or sedation to induce sleep. There are, however, growing concerns regarding sedating antihistamine misuse.
P. J. Oyekan, H. Gorton, C. Copeland
semanticscholar   +1 more source

Antihistamine use during breastfeeding with focus on breast milk transfer and safety in humans: A systematic literature review

Basic & Clinical Pharmacology & Toxicology, 2021
Current data on use of antihistamines during breastfeeding and risks to the breastfed infant are insufficient. The aim of this systematic review was to provide an overview of studies measuring the levels of antihistamines in human breast milk, estimating
Elin Ngo, O. Spigset, A. Lupattelli, A. Panchaud, P. Annaert, K. Allegaert, H. Nordeng   +6 more
semanticscholar   +1 more source

Plasmodium chaperonin TRiC/CCT identified as a target of the antihistamine clemastine using parallel chemoproteomic strategy

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance New drugs targeting multiple Plasmodium parasite life stages are desperately needed to combat malaria drug resistance. The antihistamine clemastine inhibits multiple parasite forms with previously unknown molecular targets.
Kuan‐Yi Lu, Baiyi Quan, Kayla Sylvester, Tamanna Srivastava, M. Fitzgerald, E. Derbyshire   +5 more
semanticscholar   +1 more source

The KAAACI/KDA Evidence-Based Practice Guidelines for Chronic Spontaneous Urticaria in Korean Adults and Children: Part 2. Management of H1-Antihistamine-Refractory Chronic Urticaria

Allergy Asthma and Immunology Research, 2020
Quite a few patients with chronic spontaneous urticaria (CSU) are refractory to H1-antihistamines, even though the dose of H1-antihistamines is increased up to 4-fold. CSU that is not controlled with H1-antihistamines results in increased disease burden.
Jeong-Hee Choi, Dong Hun Lee, W. Song, M. Choi, Jae-Woo Kwon, G. Kim, M. Kim, Mi Ae Kim, Min Hye Kim, B. Kim, Sujeong Kim, J. Kim, J. Kim, J. Kim, J. Kim, H. Kim, Hye One Kim, H. Kim, J. Roh, K. Park, K. Park, H. Park, Hyunsun Park, J. Bae, J. Byun, D. Song, Y. Ahn, Seung Eun Lee, Y. Lee, Joong-Sun Lee, J. H. Lee, Kyung-Hwan Lim, S. Youn, Yoon-Seok Chang, Y. H. Jeon, J. Jeon, M. Jue, S. Choi, G. Hur, D. Lim, Y. Ye, Y. Park   +41 more
semanticscholar   +1 more source

Use of antihistamine medications during early pregnancy and selected birth defects: The National Birth Defects Prevention Study, 1997–2011

Birth Defects Research, 2020
It is estimated that approximately 10–15% of pregnant women report antihistamine use during pregnancy. Although antihistamines are generally considered safe during pregnancy, results from published studies are inconsistent.
C. Hansen, Tania A Desrosiers, K. Wisniewski, M. Strickland, M. Werler, S. Gilboa   +5 more
semanticscholar   +1 more source

The Antihistamine Drugs Carbinoxamine Maleate and Chlorpheniramine Maleate Exhibit Potent Antiviral Activity Against a Broad Spectrum of Influenza Viruses

Frontiers in Microbiology, 2018
Influenza A viruses (IAV) comprise some of the most common infectious pathogens in humans, and they cause significant mortality and morbidity in immunocompromised people as well as children and the elderly.
Wei Xu, Shuai Xia, Jing Pu, Qian Wang, Peiyu Li, Lu Lu, Shibo Jiang, Shibo Jiang   +7 more
doaj   +1 more source