Results 161 to 170 of about 9,174 (251)
The potential for biased signalling in the P2Y receptor family of GPCRs
British Journal of Pharmacology, EarlyView.The purinergic receptor family is primarily activated by nucleotides, and contains members of both the G protein coupled‐receptor (GPCR) superfamily (P1 and P2Y) and ligand‐gated ion channels (P2X). The P2Y receptors are widely expressed in the human body, and given the ubiquitous nature of nucleotides, purinergic signalling is involved with a plethora Claudia M. Sisk, Simon Pitchford, Graham Ladds +2 morewiley +1 more sourceSignal detection and characterisation of a novel drug–drug interaction between methadone and a synthetic cannabinoid receptor agonist
British Journal of Pharmacology, EarlyView.Background and Purpose
Little is known about how synthetic cannabinoid receptor agonist (SCRA) co‐use with other psychoactive substances may exacerbate risk of death. This study aimed to characterise the polypharmacy of deaths where SCRAs were detected at post‐mortem, investigate the cardiotoxicity of SCRAs and probe their inhibition of human ether‐a ...Kirsten L. Rock, Louise M. Hesketh, Hongwei Cheng, Shuoqi Chen, Simon Hudson, Graeme Henderson, Jules C. Hancox, Michael J. Shattock, Michael J. Curtis, Caroline S. Copeland +9 morewiley +1 more sourceAdherence to Treatment in Allergic Rhinitis During the Pollen Season in Europe: A MASK‐air Study
Clinical &Experimental Allergy, Volume 55, Issue 3, Page 226-238, March 2025.In a study assessing mobile health data, (i) adherence to rhinitis medication was highest for oral antihistamines and lowest for azelastine‐fluticasone, (ii) in weeks of partial adherence, azelastine‐fluticasone was associated with lower levels of reported rhinitis symptoms than other medication classes.Bernardo Sousa‐Pinto, Elísio M. Costa, Rafael José Vieira, Ludger Klimek, Wienczyslawa Czarlewski, Oliver Pfaar, Anna Bedbrook, Rita Amaral, Luisa Brussino, Violeta Kvedariene, Desiree E. Larenas‐Linnemann, Tomohisa Iinuma, Nhân Pham‐Thi, Frederico S. Regateiro, Luis Taborda‐Barata, Maria Teresa Ventura, Ignacio J. Ansotegui, Karl C. Bergmann, G. Walter Canonica, Victoria Cardona, Lorenzo Cecchi, Ivan Cherrez‐Ojeda, Cemal Cingi, Alvaro A. Cruz, Stefano Del Giacco, Philippe Devillier, Wytske J. Fokkens, Bilun Gemicioglu, Tari Haahtela, Juan Carlos Ivancevich, Piotr Kuna, Helga Kraxner, Daniel Laune, Renaud Louis, Michael Makris, Mario Morais‐Almeida, Ralph Mösges, Marek Niedoszytko, Nikolaos G. Papadopoulos, Vincenzo Patella, Ana Margarida Pereira, Sietze Reitsma, Karla Robles‐Velasco, Philip W. Rouadi, Boleslaw Samolinski, Milan Sova, Sanna K. Toppila‐Salmi, Joaquin Sastre, Arunas Valiulis, Arzu Yorgancioglu, Mihaela Zidarn, Torsten Zuberbier, Joao A. Fonseca, Jean Bousquet, the MASK‐air think tank, Josep M. Anto, Maciej Kupczyk, Marek Kulus, Nicolas Roche, Nicola Scichilone, Rute Almeida, Sinthia Bosnic‐Anticevich, Fulvio Braido, Claudia Chaves Loureiro, Govert de Vries, Antonio F. M. Giuliano, Cristina Jácome, Igor Kaidashev, Gilles Louis, Olga Lourenço, Mika Makela, Marcus Maurer, Joaquim Mullol, Rachel Nadif, Robyn O’Hehir, Yoshitaka Okamoto, Markus Ollert, Heidi Olze, Benoit Pétré, Francesca Puggioni, Jan Romantowski, Daniela Rivero‐Yeverino, Monica Rodriguez‐Gonzalez, Ana Sá‐Sousa, Marine Savouré, Faradiba S. Serpa, Mohamed H. Shamji, Aziz Sheikh, Charlotte Suppli Ulrik, Mikhail Sofiev, Annette Sperl, Ana Todo‐Bom, Ioanna Tsiligianni, Erkka Valovirta, Michiel van Eerd, Hubert Blain, Louis‐Philippe Boulet, Guy Brusselle, Roland Buhl, Denis Charpin, Thomas Casale, Tomas Chivato, Jaime Correia‐de‐Sousa, Christopher Corrigan, Frédéric de Blay, Mark Dykewicz, Alessandro Fiocchi, Mattia Giovannini, Ewa Jassem, Marek Jutel, Thomas Keil, Stefania La Grutta, Brian Lipworth, Alberto Papi, Jean‐Louis Pépin, Santiago Quirce, Carlos Robalo Cordeiro, Maria J. Torres, Omar S. Usmani, Matteo Bonini, Brigita Gradauskiene, Christopher Brightling +121 morewiley +1 more sourceResearch Priorities for Children With Food Allergy: A UK James Lind Alliance Priority Setting Partnership
Clinical &Experimental Allergy, EarlyView.The UK childhood food allergy James Lind Alliance Priority Setting Partnership collaboratively identified the most important research priorities highlighting the breadth of research required to improve the prevention, diagnosis, treatment and broader impacts of food allergy on those directly impacted. These provide a clear, stakeholder‐driven agenda to Roxanne M. Parslow, Farhad Shokraneh, Sara J. Brown, Mary Feeney, Graham Roberts, Hora Soltani, Joanne Walsh, Amy Dobson, Emma Vaughan, Deborah Marriage, Suzi Holland, Mary Kelly, Holly Shaw, Alicia Kennedy, Eden Byrne, Liliana Jackson, Gail Jackson, Lauren Gluyas, Jonathan Gower, Alyson Huntley, Matthew J. Ridd +20 morewiley +1 more sourceVoice Fundamental Frequency Variation and Statin Therapy
Clinical Otolaryngology, EarlyView.ABSTRACT Objectives
Statins are considered a first‐line treatment for dyslipidaemia, being the most frequently prescribed medicine worldwide. However, statin therapy has been associated with several adverse effects, including statin‐associated myopathy, which may manifest with symptoms such as myalgia, muscle stiffness, and cramps.Luca Francesco Parata, Paola Andreozzi, Lydia Thaleia Tzigkie, Marco de Vincentiis, Diletta Angeletti, Massimo Fusconi +5 morewiley +1 more sourceIncidence, severity and potential pathomechanism of immune‐related pruritus in melanoma patients undergoing immune checkpoint inhibitor therapy
JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.Summary Background and objectives
Pruritus is a frequent cutaneous immune‐related adverse event (irAE) associated with immune checkpoint inhibitors (ICI), impacting patients' quality of life. This study investigates the incidence, severity and management of pruritus in melanoma patients treated with ICI.Andrea Roggo, Nikolina Ivanovic, Patrick Turko, Lukas Kraehenbuehl, Mitchell Levesque, Reinhard Dummer, Barbara Meier‐Schiesser +6 morewiley +1 more source
