Results 161 to 170 of about 93,278 (263)

Non‐canonical PKG1 regulation in cardiovascular health and disease

British Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

Genetically proxied therapeutic effect of antihypertensive drug use, breast cancer, and ovarian cancer's risk: a drug-target Mendelian randomization study. [PDF]

BMC Cancer
Dang C, Wang R, Shi Y, Liu P, Wang X, Liu J, Yu X, Jin D, Ma Q.   +8 more
europepmc   +1 more source

Renal‐vascular axis: unmasking its role in vascular endothelial growth factor‐inhibitor vascular toxicity in cancer patients

British Journal of Pharmacology, EarlyView.
Abstract Vascular toxicity is a growing concern in cancer patients receiving vascular endothelial growth factor inhibitor (VEGFi) therapy, posing a significant threat to patient prognosis. While the primary mechanism of VEGFi‐induced vascular toxicity is linked to redox‐sensitive reactions that disrupt vascular tone, leading to hypertension and ...
Grace Whelan, Karla B. Neves
wiley   +1 more source

Antihypertensive Drug Treatment and the Risk for Intrahemodialysis Hypotension. [PDF]

Clin J Am Soc Nephrol
Zoccali C, Tripepi G, Carioni P, Fu EL, Dekker F, Stel V, Jager KJ, Mallamaci F, Hymes JL, Hymes JL, Maddux FW, Stuard S.   +11 more
europepmc   +1 more source

Heart failure medication to prevent cancer therapy–related cardiac dysfunction: A narrative review

British Journal of Pharmacology, EarlyView.
Advances in oncological therapies have improved cancer survival but also have increased the clinical incidence of cancer therapy–related cardiac dysfunction (CTRCD), a spectrum of conditions ranging from subclinical biomarker or strain abnormalities to progressive heart failure and cardiogenic shock.
Fabian Voß, Paul Goerke, Malte Kelm, Amin Polzin   +3 more
wiley   +1 more source

Advanced electrochemical detection and profiling of the antihypertensive drug atenolol <i>via</i> a SPION-activated carbon nanocomposite interface. [PDF]

Nanoscale Adv
Agnihotri AS, M N.
europepmc   +1 more source

Effect of Medication Intake on Dental Implant‐Related Outcomes—A Scoping Review

Clinical Oral Implants Research, EarlyView.
ABSTRACT Objective The objective of this scoping review was to evaluate the effect of systemic medications on dental implant outcomes in medically compromised patients. Material and Methods Electronic and manual searches were conducted for this scoping review.
Alberto Monje, Maria Costanza Soldini, Emilio Couso‐Queiruga, Álvaro Babiano, Vivianne Chappuis   +4 more
wiley   +1 more source

Antihypertensive Drug Use and COVID-19 Disease Severity in Hospitalized US Veterans: A Retrospective Cohort Study. [PDF]

J Clin Hypertens (Greenwich)
Huntsman M, Marquez JL, Stoddard GJ, Wei G, Miller AJ, Agarwal JP, Jeyapalina S.   +6 more
europepmc   +1 more source

Effect of interdisciplinary obesity care on metabolic markers and body weight in people with type 2 diabetes in a rural setting: A randomised controlled trial

Clinical Obesity, Volume 15, Issue 2, April 2025.
Summary Management of type 2 diabetes includes medications that can unintentionally increase obesity and insulin resistance. This unblinded, single‐centre, randomised controlled trial focused on rural Australian adults with type 2 diabetes (aged 18–75 and body mass index [BMI] >30 kg/m2), measuring the effectiveness of a tailored interdisciplinary ...
Giuliana O. Murfet, Iain K. Robertson, Sharon P. Luccisano, Michelle L. Kilpatrick   +3 more
wiley   +1 more source

Genetically proxied therapeutic inhibition of antihypertensive drug targets and risk of pancreatic cancer: a mendelian randomization analysis. [PDF]

BMC Cancer
Yao Z, Qin D, Cao J, Gao C, Xi P, Li S, Wei R.   +6 more
europepmc   +1 more source