Results 181 to 190 of about 113,882 (274)

From Design to Bioactivity: 2‐Benzoylpyridine 4‐(bicyclo[2.2.1]hept‐2‐yl)thiosemicarbazone and Its 3d Metal Coordination Compounds

ChemistryOpen, Volume 15, Issue 4, April 2026.
The new 2‐benzoylpyridine 4‐(bicyclo[2.2.1]hept‐2‐yl)thiosemicarbazone (HL) and its copper(II), nickel(II), cobalt(III), and iron(III) coordination compounds [Cu(L)Cl] (1), [Cu(L)NO3] (2), {[Cu(L)(Cl2CHCOO)]}n (3), [Ni(HL)2](NO3)2 (4), [Fe(L)2]NO3 (5), [Co(L)2]NO3 (6) were obtained.
Ianina Graur, Vasilii Graur, Elena Melnic, Carolina Lozan‐Tirsu, Greta Balan, Victor Tsapkov, Aurelian Gulea   +6 more
wiley   +1 more source

Access to antimalarial drugs in the Asia-Pacific region during health emergency: a multinational cross-sectional investigation between 2020 and 2022. [PDF]

Glob Health Res Policy
Sun Y, Cui Y, Huang Y, Xu M.
europepmc   +1 more source

Comprehensive Analysis of Structure Activity Relationships in Quinoxaline Derivatives Covering Antimicrobial Applications

ChemistrySelect, Volume 11, Issue 14, 13 April 2026.
ABSTRACT Antimicrobial resistance (AMR) has emerged as one of the most critical global health challenges, undermining the clinical efficacy of existing antibiotics and threatening modern therapeutic strategies. The ongoing misuse and overuse of antimicrobial agents have accelerated the evolution of resistant bacterial strains and parasites ...
Subham Kumar Vishwakarma, Fernando Rogério Pavan, Cesar Augusto Roque‐Borda   +2 more
wiley   +1 more source

Parasitological efficacy of seasonal malaria chemoprevention in Nampula, northern Mozambique. [PDF]

Trans R Soc Trop Med Hyg
Bonnington C, Sitoe M, Pulido Tarquino IA, Enosse SM, Sararat C, Suwannasin K, Proux S, Koesukwiwat U, Tarning J, Imwong M, Theiss-Nyland K, Nosten FH, White NJ.   +12 more
europepmc   +1 more source

Catalytic Scalable Synthesis of Polyketides Enabled by Chiral Brønsted Acid‐Catalyzed Asymmetric Allylborations

The Chemical Record, Volume 26, Issue 4, April 2026.
The scalable synthesis of target molecules is crucial for applications such as biological evaluation in medicinal chemistry and even industrial production. We described recent advances in chiral Brønsted acid–catalyzed asymmetric allylboration, which enables access to previously elusive chiral building blocks, and highlight its application to the ...
Shigenobu Umemiya, Masahiro Terada
wiley   +1 more source

Gene Expression, Docking and Machine Learning in Malaria Drug Discovery: A Systematic Review. [PDF]

Biochem Res Int
Dangana RS, Ebhohimen IE, Malgwi SA, Ugbaja SC, Okpeku M.   +4 more
europepmc   +1 more source

Integrating mass spectrometry and systems biology for the modernization of natural medicines: From deciphering chemical complexity to holistic efficacy assessment

VIEW, Volume 7, Issue 2, April 2026.
This review explores how mass spectrometry is transforming research in natural medicines, with Traditional Chinese medicine (TCM) as a primary exemplar. It details the application of advanced mass spectrometry in chemical analysis, the development of comprehensive quality control methods, and systematic research on the targeted mechanisms of single ...
Yudian Xu, Linlin Cao, Chenhuan Ding, Chen Wang, Yi Lai, Dan Ru, He Li, Wei Xu   +7 more
wiley   +1 more source

The return of metabolism: biochemistry and physiology of glycolysis

Biological Reviews, Volume 101, Issue 2, Page 751-803, April 2026.
ABSTRACT Glycolysis is a fundamental metabolic pathway central to the bioenergetics and physiology of virtually all living organisms. In this comprehensive review, we explore the intricate biochemical principles and evolutionary origins of glycolytic pathways, from the classical Embden–Meyerhof–Parnas (EMP) pathway in humans to various prokaryotic and ...
Nana‐Maria Grüning, Federica Agostini, Camila Caldana, Johannes Hartl, Matthias Heinemann, Markus A. Keller, Jan Lukas Krüsemann, Costanza Lamperti, Carole L. Linster, Steffen N. Lindner, Julia Muenzner, Jens Nielsen, Zoran Nikoloski, Bettina Siebers, Jacky L. Snoep, Hezi Tenenboim, Bas Teusink, Spencer J. Williams, Mirjam M. C. Wamelink, Markus Ralser   +19 more
wiley   +1 more source

In- vitro assessment of the anti- malarial potential of Alpha Onocerin; cytotoxicity and hemolytic effect, multi-stage activity and molecular docking. [PDF]

BMC Pharmacol Toxicol
Appiah JA, Tetteh J, Zoiku F, Amoatey AO, Osei KJ, Agyemang Antwi S, Addotey JN, Ansah C, Mensah KB.   +8 more
europepmc   +1 more source

Newly identified properties of known pharmaceuticals and myxobacterial small molecules revealed by screening for autophagy modulators

The FEBS Journal, Volume 293, Issue 8, Page 2314-2340, April 2026.
Autophagy is a cellular degradation process involved in, for example, immune responses to pathogens and neurodegeneration. To identify modulators of autophagy, we developed a microscopy‐based screening assay and identified previously unknown autophagy‐modulating activities in known drugs and natural products from myxobacteria and fungi.
Janine Fichtner, Yan Yan Beer, H. G. Mauricio Ramm, Sabrina Mühlen, Frank Surup, Jennifer Herrmann, Toni Luise Meister, Stephanie Pfaender, Ursula Bilitewski, Mark Brönstrup, Rolf Müller, Manfred Wirth, Eeva‐Liisa Eskelinen, Ingo Schmitz   +13 more
wiley   +1 more source