Results 161 to 170 of about 113,882 (274)

Biosynthetically‐Inspired Oxidative Cleavage Platform Enables Rapid Access to Diverse and Architecturally Complex Chemotypes From Indole Alkaloids

ChemistryEurope, Volume 4, Issue 4, April 2026.
We report a biosynthesis‐inspired ring distortion approach that involves oxidative ring cleavage, ring rearrangement, and ring expansion reactions from a diverse collection of indole alkaloids and derivatives. This chemical synthesis approach led to the synthesis of >25 distinct chemotypes from 14 indole alkaloids.
Derek A. Leas, Eli S. Levit, Alexis A. Bragg, Taylor A. Gerrein, Khalil A. Abboud, Pingrong Wei, Lukasz M. Dobrzycki, Robert W. Huigens III   +7 more
wiley   +1 more source

Chemoproteomics-based profiling elucidates the antimalarial effects of amodiaquine through disruption of glycolysis process in Plasmodium falciparum. [PDF]

Cell Commun Signal
Wang J, Wang C, Zhuge R, Tang H, Xia F, Zhang Y, Zhang J, Liu C, Wu J, Chen X, Gao P, Wang J.   +11 more
europepmc   +1 more source

Formal Synthesis of the Akuammiline Alkaloid (±)‐Strictamine via a (4 + 2) Annulation Reaction With a Donor–Acceptor Cyclobutane

Helvetica Chimica Acta, Volume 109, Issue 4, April 2026.
We report a concise formal synthesis of (±)‐strictamine via a silylium‐catalyzed (4 + 2) annulation of a donor–acceptor cyclobutane, achieved in 13 steps from tryptamine. ABSTRACT The akuammiline alkaloids are complex monoterpene indole natural products with a rigid cage‐like architecture and diverse biological activities.
Clément Tanguy, Emma G. L. Robert, Jerome Waser   +2 more
wiley   +1 more source

Liquid-Phase Peptide Synthesis of Tropolone-Peptide Hybrid Antimalarials. [PDF]

Org Lett
Sennari G, Nakajima A, Nakahara H, Saito R, Ishiyama A, Hokari R, Iwatsuki M, Hirose T, Sunazuka T.   +8 more
europepmc   +1 more source

Time to Act; Let Us Unite to Eliminate Malaria Among Pregnant Women in War Zone From Eastern Democratic Republic of the Congo: A Review

Health Science Reports, Volume 9, Issue 4, April 2026.
ABSTRACT Background Malaria remains a major public health challenge in sub‐Saharan Africa, with the Democratic Republic of the Congo (DR Congo) contributing substantially to the global burden. DR Congo accounts for 12% of global malaria cases. This study aims to assess the intersectionality of epidemiological, immunological, and conflict‐related ...
Aymar Akilimali, Laiba Mehmood, Paradzai Innocent Njazi, Babar Ali, Saad Maqbool, Muhammad Younas, Martin Sagide, Syeda Vilay Zehra Rizvi, Rabbia Munsab, Syeda Umme Abiha Rizvi, Sabika Fatima, Amidu Alhassan, Calvin R. Wei, Amos Kipkorir Langat   +13 more
wiley   +1 more source

A Fe-incorporated bioreactor platform exhibiting antimalarial activity and enhanced response to artemisinin. [PDF]

Antimicrob Agents Chemother
Li Y, Li S, Li H, Yang Y, Xu J, Deng Y, He X, Tian F, Han J-H, Han E-T, Xi J, Lu F.   +11 more
europepmc   +1 more source

Detection of malaria in relation to fever and grade of malnutrition among malnourished children in Ethiopia [PDF]

, 2011
Ayada, L., Harries, A.., Hinderaker, S.G., Jima, D., Keiluhu, A., Khogali, M., Tayler-Smith, K., Van den Brande, K., Zachariah, R.   +8 more
core   +2 more sources

Strengthening Pharmacogenomics Implementation in Africa: Challenges and Opportunities ‐ A Narrative Review

Health Science Reports, Volume 9, Issue 4, April 2026.
ABSTRACT Background and Aim The discipline of pharmacogenomics (PGx) studies the influence of genetic diversity on drug response, bringing the potential to personalized treatment and reduction of adverse effects. Although PGx integration into healthcare is progressing at a global scale, its implementation in Africa faces unique challenges and ...
Esther Mukabyiringiro, Andrew Wainaina Kinyanjui, Gachie Ruth Nthenya, Okoth Zifion Ndiege, Daniel Alaak Majok, Samuel Inshutiyimana, Ermias Mergia Terefe   +6 more
wiley   +1 more source

Prevalence, Etiology, and Antifungal Resistance Profiles of Ocular Fungal Infections in Ghanaian Ophthalmic Patients: A Multicenter Cross‐Sectional Study

Health Science Reports, Volume 9, Issue 4, April 2026.
ABSTRACT Background and Aims Ocular fungal infections are an important but often underrecognized cause of ocular morbidity, particularly in resource‐limited settings. Delayed diagnosis and inappropriate treatment can lead to poor visual outcomes and increased disease burden.
Isaiah Osei Duah Junior, Abigail Oforiwaa Boateng, Kwadwo Owusu Akuffo, Lord Gyimah, Kingsley Badu   +4 more
wiley   +1 more source

Cerebral malaria: of mice and men. [PDF]

Trans R Soc Trop Med Hyg
Weerasekera CJ, White NJ.
europepmc   +1 more source