Results 91 to 100 of about 2,234,657 (224)

Quality of antimalarial drugs and antibiotics in Papua New Guinea : a survey of the health facility supply chain [PDF]

, 2014
Poor-quality life-saving medicines are a major public health threat, particularly in settings with a weak regulatory environment. Insufficient amounts of active pharmaceutical ingredients (API) endanger patient safety and may contribute to the ...
Betuela Inoni, Davis, T., Page-Sharp Madhu, Betuela, I., Page-Sharp, Madhu, Bala, Nancy, Bala Nancy, Manuel W Hetzel, Timothy M E Davis, Evelyn K Lavu, Pulford Justin, Lavu, Evelyn K., Nancy Bala, Nancy Bala (563875), Hetzel Manuel W., Davis Timothy M. E., Madhu Page-Sharp (563874), Evelyn K. Lavu (563877), Davis, Timothy M. E., Lavu Evelyn K., Justin Pulford, Lavu, E., Bala, N., Pulford, J., Madhu Page-Sharp, Betuela, Inoni, Inoni Betuela, Hetzel, M., Hetzel, Manuel W., Pulford, Justin, Justin Pulford (563876), Inoni Betuela (67110), Timothy M. E. Davis (112260), Manuel W. Hetzel (563873)   +33 more
core   +2 more sources

Characterization of Sec14 Domain–Containing Proteins in the Malaria Parasite Plasmodium falciparum

Molecular Microbiology, EarlyView.
During asexual blood‐stage development, P. falciparum Sec14 proteins display distinct localizations suggesting specialized roles in lipid exchange. PfSec14‐1 initially localizes to the nucleus before moving to the ER and Golgi alongside PfSec14‐4 during schizogony.
Florian Lauruol, Dominik Šťastný, J. Pedro Fernandez‐Murray, Christopher R. McMaster, Peter Griač, Dave Richard   +5 more
wiley   +1 more source

Safety, efficacy and pharmacokinetics profile of antimalarial drugs in pregnancy : pharmacoepidemiology studies [PDF]

, 2014
Background: Malaria in pregnancy is an important public health problem in sub Saharan Africa. It is known to be the most common and preventable cause of harmful birth outcomes in malaria endemic areas. It is therefore important for a pregnant woman to be
Mosha, Dominic
core   +1 more source

Trichomes in Plant Defence, Development and Metabolic Integration Under Environmental Stress

Plant, Cell &Environment, EarlyView.
ABSTRACT Among various plant defence strategies, trichomes are tiny hair‐like structures on the epidermis that aid in defence, environmental adaptation and the production of valuable secondary metabolites. This review features trichomes as frontline guards for plant survival, integrating their structural, physiological and metabolic roles in ...
Debdatta Chatterjee, Madhabi Das, Sanjib Patra, Srijib Chatterjee, Amit Roy, Arunava Mandal   +5 more
wiley   +1 more source

Developmental Toxicity Study for the Antimalarial Drug Combination Cabamiquine‐Pyronaridine Using a Translational Approach

Birth Defects Research, Volume 118, Issue 10, October 2026.
ABSTRACT Background The safety of pharmacological treatments during pregnancy is a significant concern, as many medications lack comprehensive reproductive safety data. This creates gaps in therapeutic options for pregnant women, particularly malaria, which poses serious risks to maternal and fetal health.
Wookyung Kim, Geum‐Sil Cho, Andreas Gado, Tobias Hyun Ho Baeurle, Habib Karimi, Filippo Venezia, Claude Oeuvray, Thomas Spangenberg, Sebastian G. Wicha, Claudia Demarta‐Gatsi   +9 more
wiley   +1 more source

The effect of mefloquine dose on outcome of uncomplicated falciparum malaria treated with artesunate-mefloquine: a WWARN systematic review and individual patient data meta-analysis

Malaria Journal
Introduction A combination of mefloquine associated with artesunate (AS-MQ) was the first artemisinin-based combination therapy (ACT) to be used widely for acute uncomplicated P. falciparum malaria.
The WWARN AS-MQ Dose Impact Study Group
doaj   +1 more source

Capacity Development through the US President’s Malaria Initiative–Supported Antimalarial Resistance Monitoring in Africa Network

Emerging Infectious Diseases, 2017
Antimalarial drug resistance is an evolving global health security threat to malaria control. Early detection of Plasmodium falciparum resistance through therapeutic efficacy studies and associated genetic analyses may facilitate timely implementation of
Eric S. Halsey, Meera Venkatesan, Mateusz M. Plucinski, Eldin Talundzic, Naomi W. Lucchi, Zhiyong Zhou, Celine I. Mandara, Hawela Moonga, Busiku Hamainza, Abdoul Habib Beavogui, Simon Kariuki, Aaron M. Samuels, Laura C. Steinhardt, Don P. Mathanga, Julie Gutman, Yves Eric Denon, Aline Uwimana, Ashenafi Assefa, Jimee Hwang, Ya Ping Shi, Pedro Rafael Dimbu, Ousmane Koita, Deus S. Ishengoma, Daouda Ndiaye, Venkatachalam Udhayakumar   +24 more
doaj   +1 more source

Traditional Uses, Phytochemistry, and Multi‐Target Pharmacological Activities of Senna alexandrina

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Senna alexandrina is a medicinally important plant with documented use across Traditional Chinese, Islamic, Ayurvedic, and Unani medicine systems. Phytochemical investigations have yielded 219 characterized compounds, predominantly anthraquinones, flavonoids, and polysaccharides, distributed across leaves, pods, and aerial parts.
Diana Afrina Rella, Khai‐Lin Hew, Yeun‐Mun Choo   +2 more
wiley   +1 more source

Antimalarial drug resistence and artemisinin based combination therapy : a bio-economic model for elucidating policy choices [PDF]

Antimalarial drug resistance is a major cause of the increasing burden due to P. falciparum malaria. Artemisinin-based combination therapies (ACTs) are now recognised to be the ideal choice for the first-line treatment of ...
Yeung, Shunmay
core   +1 more source

Individual patient data meta-analysis: a cost-effective and efficient tool to advance paediatric research in low- and middle-income countries

BMJ Open
There is a deficit between existing levels of paediatric clinical research in low- and middle-income countries (LMICs) and what is warranted based on the disease burden in children in these countries.
Andrew Farlow, Frederick McElwee, Philippe J. Guerin   +2 more
doaj   +1 more source