Results 81 to 90 of about 2,234,657 (224)

The antimalarial efficacy and mechanism of resistance of the novel chemotype DDD01034957

Scientific Reports, 2021
New antimalarial therapeutics are needed to ensure that malaria cases continue to be driven down, as both emerging parasite resistance to frontline chemotherapies and mosquito resistance to current insecticides threaten control programmes.
Celia Miguel-Blanco, James M. Murithi, Ernest Diez Benavente, Fiona Angrisano, Katarzyna A. Sala, Donelly A. van Schalkwyk, Manu Vanaerschot, Frank Schwach, Matthew J. Fuchter, Oliver Billker, Colin J. Sutherland, Susana G. Campino, Taane G. Clark, Andrew M. Blagborough, David A. Fidock, Esperanza Herreros, Francisco Javier Gamo, Jake Baum, Michael J. Delves   +18 more
doaj   +1 more source

Antimalarial Drug Resistance: A Threat to Malaria Elimination [PDF]

Cold Spring Harbor Perspectives in Medicine, 2017
Increasing antimalarial drug resistance once again threatens effective antimalarial drug treatment, malaria control, and elimination. Artemisinin combination therapies (ACTs) are first-line treatment for uncomplicated falciparum malaria in all endemic countries, yet partial resistance to artemisinins has emerged in the Greater Mekong Subregion ...
Menard, D, Dondorp, A
openaire   +2 more sources

Repurposing antimicrobial agents for neuroprotection: Mechanisms, clinical potential, and challenges

Neuroprotection, EarlyView.
Antimicrobial agents exert neuroprotective effects through modulation of interconnected pathways. Tetracyclines, macrolides, antimalarial agents, sulfones, and antiparasitic agents suppress neuroinflammation, oxidative stress, and apoptosis while preserving mitochondrial function and neurotransmission.
Mohammad Amin Manavi, Mohammadreza Salehi, Razieh Mohammad Jafari, Ramin Goudarzi, Saman Khosravi, Ahmad Reza Dehpour   +5 more
wiley   +1 more source

Spread of anti-malarial drug resistance: mathematical model with implications for ACT drug policies. [PDF]

, 2008
BACKGROUND: Most malaria-endemic countries are implementing a change in anti-malarial drug policy to artemisinin-based combination therapy (ACT). The impact of different drug choices and implementation strategies is uncertain.
Hastings, Ian M, Day, Nicholas PJ, White, Nicholas J., Dondorp, AM, Hastings, Ian M., Dondorp, Arjen M, Dondorp, Adrianus, Hastings, Ian, Day, Nicholas P. J., Pongtavornpinyo, W, Hastings, IM, Pongtavornpinyo, Wirichada, White, Nicholas J, Day, Nicholas, Day, Nicholas P.J., Yeung, Shunmay, Day, NP, White, NJ, White, Nicholas, Dondorp, Arjen M., Yeung, S, Hastings Ian M, Dondorp Arjen M, Pongtavornpinyo Wirichada, Day Nicholas PJ, Yeung Shunmay, White Nicholas J   +26 more
core   +1 more source

Electrochemical aptasensors for ultrasensitive multiplexed detection: Towards a new era of precision diagnostics and environmental monitoring

VIEW, EarlyView.
Electrochemical aptasensors are emerging as powerful platforms for precision diagnostics and environmental monitoring, owing to their high selectivity, programmability and compatibility with miniaturised systems. However, their broader application is constrained by limited signal intensity and challenges in reliable multiplexed detection.
Azadeh Abdi, Ngoan Thi Thao Nguyen, Riccardo Zulli, Jacopo Giaretta, Fariba Dehghani, Syamak Farajikhah   +5 more
wiley   +1 more source

Selection of antimalarial drug resistance after intermittent preventive treatment of infants and children (IPTi/c) in Senegal. [PDF]

, 2013
Our study investigated the possible impact of SP-IPT given to infants and children on the prevalence of SP-resistant haplotypes in the Plasmodium falciparum genes Pfdhfr and Pfdhps, comparing sites with and without IPTi/c. P. falciparum positive samples (
Dieng, Yémou, Sylla, Khadime, Lo, Ami Colle, Jean L. Ndiaye, Ndiaye, Magatte, Khadime Sylla, Hallett, Rachel, Ndiaye, Jean Louis, Magatte Ndiaye, Rachel Hallett, Ndiaye, Jean L, Diouf, Ibrahima, Tine, Roger, Abiola, Annie, Ibrahima Diouf, Ndiaye, Daouda, Aminata C. Lo, Yemou Dieng, Roger Tine, Faye, Babacar, Babacar Faye, Gaye, Oumar, Lo, Aminata C, Oumar Gaye, Michael Alifrangis, Alifrangis, Michael   +25 more
core   +1 more source

PEG400 regulates Falcipain 2 activity through an allosteric mechanism

The FEBS Journal, EarlyView.
Falcipain‐2 can potentially be leveraged as a drug target due to its critical role as a haemoglobinase during the intra‐erythrocytic stage of Plasmodium falciparum. Here, we investigate the regulation of the proteolytic and haemoglobinase activity of falcipain‐2 in the presence of polyethylene glycol.
Bikram Nath, Subhoja Chakraborty, Sampa Biswas   +2 more
wiley   +1 more source

Multiple origins and regional dispersal of resistant dhps in African Plasmodium falciparum malaria. [PDF]

, 2009
BACKGROUND: Although the molecular basis of resistance to a number of common antimalarial drugs is well known, a geographic description of the emergence and dispersal of resistance mutations across Africa has not been attempted.
Kweku Margaret, Grobusch, Martin P., Rwakimari John B., Malisa, Allen L., Kachur S. Patrick, Uusiku, P., Giha, Hayder A., El-Hadj Bâ, Olufunmilayo Y Elegba, Bâ El-Hadj, Chanda, P., Mbacham, Wilfred, Diallo Diadier A., Hirva Pota, Kweku, Margaret, Guthmann, J. P., Ord, Rosalynn, van den Broek, Ingrid V, Diadier A Diallo, Mombo-Ngoma, Ghyslain, Clarke, S., Owusu-Agyei Seth, Swarthout Todd D., Rwakimari, John B, Barnes, K. I., Cissé Badara, Lynch, C., Alexandre Matondo, Pota Hirva, Pearce, Richard J., Chandramohan, Daniel, Chanda, Pascalina, Streat, Elizabeth, Katokele Stark T., Kachur, S Patrick, Naidoo, I., Lynch, Caroline, Rosalynn Ord, Ishraga E A-Elbasit, Elegba, Olufunmilayo Y, Ingrid V van den Broek, Badara Cissé, Katokele, Stark T., A-Elbasit, Ishraga E., Mbacham, W., Caroline Lynch, Brian Sharp, Evehe, M. S. B., Mombo-Ngoma, G., Margaret Kweku, Owusu-Agyei, Seth, Cally Roper, Pearce Richard J., Grobusch, M. P., Bonnet, M., Sharp Brian, Dunyo, S., Uusiku, Petrina, Kweku, M., Matondo, Alexandre, Moonga Hawela, Evehe, Marie-Solange B, Rwakimari, John B., Giha, Hayder A, Jean-Paul Guthmann, S Patrick Kachur, Evehe, Marie-Solange B., Giha, H. A., Swarthout, Todd D., Guthmann Jean-Paul, Kachur, S. Patrick, Pota, Hirva, Hawela, Moonga, Allen L Malisa, Barnes, Karen I, Matondo, A., Dejene, S., Inojosa Walter, Grobusch Martin P., Mbacham Wilfred, Elegba, O. Y., Asefaw Getachew, A-Elbasit Ishraga E., A-Elbasit, I. E., Agboghoroma, Chris O, Katokele, S. T., Bâ, El-Hadj, Malisa, A. L., Agboghoroma, Chris O., Bonnet Maryline, Inojosa, Walter, Pearce, Richard J, Njie, Fanta, Todd D Swarthout, John B Rwakimari, Agboghoroma, C. O., Daniel Chandramohan, van den Broek, I. V., Swarthout, T. D., Grobusch, Martin P, Katokele, Stark T, Getachew, A., Pascalina Chanda, Matondo Alexandre, Elegba, Olufunmilayo Y., Barnes Karen I., Giha Hayder A., Hawela, M., Richard J Pearce, Chandramohan Daniel, Diallo, Diadier A., Roper, C., Chanda Pascalina, Roper, Cally, Owusu-Agyei, S., van den Broek, Ingrid V., Hayder A Giha, Bonnet, Maryline, Dunyo, Samuel, Pota, H., Uusiku Petrina, Martin P Grobusch, Inbarani Naidoo, Guthmann, Jean-Paul, Dejene, Seyoum, Chris O Agboghoroma, Pearce, R. J., Cissé, B., Getachew Asefaw, Bâ, El Hadj, Elizabeth Streat, Streat Elizabeth, Malisa Allen L., Elegba Olufunmilayo Y., Sharp, Brian, Naidoo Inbarani, Sian Clarke, Samuel Dunyo, Malisa, Allen L, Maryline Bonnet, Walter Inojosa, Sharp, B., Cissé, Badara, Diallo, D. A., Streat, E., Barnes, Karen I., A-Elbasit, Ishraga E, Clarke, Sian, Mombo-Ngoma Ghyslain, Swarthout, Todd D, Njie, F., Ord Rosalynn, Diallo, Diadier A, Stark T Katokele, Ghyslain Mombo-Ngoma, Karen I Barnes, Hawela Moonga, Inojosa, W., Agboghoroma Chris O., Roper Cally, Getachew, Asefaw, Clarke Sian, Evehe Marie-Solange B., Seyoum Dejene, Seth Owusu-Agyei, Wilfred Mbacham, Kachur, S. P., Rwakimari, J. B., Dejene Seyoum, Njie Fanta, Naidoo, Inbarani, van den Broek Ingrid V., Dunyo Samuel, Ord, R., Lynch Caroline, Chandramohan, D., Marie-Solange B Evehe, Fanta Njie, Petrina Uusiku   +178 more
core   +2 more sources

Transgenic selection and underlying mechanisms in apicomplexan parasites

The FEBS Journal, EarlyView.
Transgenic selection markers have driven genetic engineering in apicomplexans, enabling precise, iterative experiments. This review discusses mechanistic details of drug selection markers, strategies for marker recycling, and practical considerations for several clinically relevant parasites.
Swaroop Peddiraju, Rakhee Lohia, Nishith Gupta   +2 more
wiley   +1 more source

Tissue Resident Memory Cells: Friend or Foe?

Immunology, EarlyView.
Tissue‐resident memory T cells (TRM cells) are specialised immune cells in barrier tissues like the lungs, skin and gut, providing rapid host defence and tumour surveillance. Their retention and differentiation are regulated by molecules such as CD69, CD103 and TGF‐β. Dysregulation of TRM cells can lead to chronic activation, driving conditions such as
Chidimma F. Chude, Jude E. Uzonna, Janilyn Arsenio   +2 more
wiley   +1 more source