Results 61 to 70 of about 2,234,657 (224)

Concurrence of Plasmodium falciparum dhfr and crt mutations in northern Ghana. [PDF]

, 2005
BACKGROUND: Both chloroquine (CQ) and sulfadoxine-pyrimethamine (SP) are failing drugs in much of sub-Saharan Africa. Previous findings suggest an association between resistance to CQ and to SP in vivo, in vitro, and on the molecular level.
Bousema J Teun, Sauerwein, Robert W, Teunis A Eggelte, Bousema, J. Teun, Bienzle Ulrich, Bousema, J Teun, Ehrhardt, Stephan, Eggelte Teunis A, Mockenhaupt Frank P, Otchwemah, Rowland N., Ehrhardt Stephan, Otchwemah, Rowland N, Bienzle, Ulrich, Mockenhaupt, Frank P., Mockenhaupt, Frank P, J Teun Bousema, Rowland N Otchwemah, Eggelte, Teunis A, Eggelte, Teunis A., Ulrich Bienzle, Stephan Ehrhardt, Otchwemah Rowland N, Sauerwein Robert W, Frank P Mockenhaupt, Robert W Sauerwein, Sauerwein, Robert W.   +25 more
core   +1 more source

Tools for surveillance of anti-malarial drug resistance: an assessment of the current landscape

Malaria Journal, 2018
To limit the spread and impact of anti-malarial drug resistance and react accordingly, surveillance systems able to detect and track in real-time its emergence and spread need to be strengthened or in some places established.
Christian Nsanzabana, Djibrine Djalle, Philippe J. Guérin, Didier Ménard, Iveth J. González   +4 more
doaj   +1 more source

The duration of chemoprophylaxis against malaria after treatment with artesunate-amodiaquine and artemether-lumefantrine and the effects of pfmdr1 86Y and pfcrt 76T: a meta-analysis of individual patient data

BMC Medicine, 2020
Background The majority of Plasmodium falciparum malaria cases in Africa are treated with the artemisinin combination therapies artemether-lumefantrine (AL) and artesunate-amodiaquine (AS-AQ), with amodiaquine being also widely used as part of seasonal ...
Michael T. Bretscher, Prabin Dahal, Jamie Griffin, Kasia Stepniewska, Quique Bassat, Elisabeth Baudin, Umberto D’Alessandro, Abdoulaye A. Djimde, Grant Dorsey, Emmanuelle Espié, Bakary Fofana, Raquel González, Elizabeth Juma, Corine Karema, Estrella Lasry, Bertrand Lell, Nines Lima, Clara Menéndez, Ghyslain Mombo-Ngoma, Clarissa Moreira, Frederic Nikiema, Jean B. Ouédraogo, Sarah G. Staedke, Halidou Tinto, Innocent Valea, Adoke Yeka, Azra C. Ghani, Philippe J. Guerin, Lucy C. Okell   +28 more
doaj   +1 more source

Synergistic Advanced Oxidation and Physicochemical Treatment Strategies for Antibiotic Removal and Resistance Mitigation in Water

Asia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT The presence of antibiotics in water not only causes environmental pollution but also increases the growth of antibiotic‐resistant bacterial genes, which pose serious threats to human beings and other water residents. Large numbers of people are reportedly affected by the resistant bacterial genes, as many broad‐spectrum antibiotics are not ...
Amir Zada, Shohreh Azizi
wiley   +1 more source

From anthelmintic to neuro‐oncology: A systematic review of mebendazole repurposing for brain tumour therapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum, Milli McMenamin, Tessa Khoo, John M. Edwin, Prathibha Jose, Liam A. O’Callaghan   +5 more
wiley   +1 more source

Persistence of chloroquine-resistant haplotypes of Plasmodium falciparum in children with uncomplicated Malaria in Lagos, Nigeria, four years after change of chloroquine as first-line antimalarial medicine. [PDF]

, 2015
BACKGROUND: In Nigeria, despite the change in National malaria drug policy to artemisinin combination therapy (ACT) in 2005 due to widespread chloroquine resistance, chloroquine (CQ) is still widely used in the treatment of malaria because it is cheap ...
Sutherland, Colin J, Oladipo, Oladosu O, Wellington, Oyibo A   +2 more
core   +1 more source

Artemisinin resistance in Plasmodium falciparum malaria. [PDF]

, 2009
BACKGROUND: Artemisinin-based combination therapies are the recommended first-line treatments of falciparum malaria in all countries with endemic disease.
Yi, Poravuth, Singhasivanon, Pratap, Day, Nicholas PJ, Ariey, Frederic, Lindegardh, Niklas, Lim, Pharath, Dondorp, Arjen M, Ringwald, Pascal, Socheat, Duong, Hanpithakpong, Warunee, Silamut, Kamolrat, Lwin, Khin Maung, Imwong, Mallika, Phyo, Aung Phae, Das, Debashish, Lee, Sue J, Herdman, Trent, White, Nicholas J, Chotivanich, Kesinee, Yeung, Shunmay, Tarning, Joel, Nosten, François, An, Sen Sam   +22 more
core   +2 more sources

Efficacy of artemisinin-based and quinine-based treatments for uncomplicated falciparum malaria in pregnancy: a protocol for systematic review and individual patient data (IPD) meta-analysis

BMJ Open, 2019
Introduction Pregnant women are more vulnerable to malaria leading to adverse impact on both mothers and fetuses. However, knowledge on the efficacy and safety of antimalarials in pregnancy is limited by the paucity of randomised control trials and the ...
Makoto Saito, François Nosten, Rose McGready, Rashid Mansoor, Kasia Stepniewska, Kalynn Kennon, Philippe J Guérin   +6 more
doaj   +1 more source

Assessing the Roles of Molecular Markers of Antimalarial Drug Resistance and the Host Pharmacogenetics in Drug-Resistant Malaria

Journal of Tropical Medicine, 2022
Malaria caused by the Plasmodium parasites is a major public health concern in malaria-endemic regions with P. falciparum causing the most severe form of the disease. The use of antimalarial drugs for the management of the disease proves to be one of the
Peter Hodoameda, Nancy Odurowah Duah-Quashie, Neils Ben Quashie   +2 more
doaj   +1 more source

Antimalarial dosing regimens and drug resistance

Trends in Parasitology, 2008
The contribution of underdosing to antimalarial treatment failure has been underappreciated. Most recommended dosage regimens are based on studies in non-pregnant adult patients. Young children and pregnant women, who bear the heaviest malaria burden, have the highest treatment failure rates.
Barnes, K, Watkins, WM, White, N
openaire   +2 more sources