Results 51 to 60 of about 2,234,657 (224)

Artemisinin antimalarials: preserving the "magic bullet" [PDF]

, 2010
The artemisinins are the most effective antimalarial drugs known. They possess a remarkably wide therapeutic index. These agents have been used in traditional Chinese herbal medicine for more then 2,000 years but were not subjected to scientific scrutiny
White, Lisa, Maude, Richard J., Maude, RJ, Richard J. Maude, White, LJ, Woodrow, CJ, White, Lisa J., Charles J. Woodrow, Lisa J. White, Woodrow, Charles J.   +9 more
core   +1 more source

Trends in health workers’ compliance with outpatient malaria case-management guidelines across malaria epidemiological zones in Kenya, 2010–2016

Malaria Journal, 2020
Background Health workers' compliance with outpatient malaria case-management guidelines has been improving, specifically regarding the universal testing of suspected cases and the use of artemisinin-based combination therapy (ACT) only for positive ...
Beatrice Amboko, Kasia Stepniewska, Peter M. Macharia, Beatrice Machini, Philip Bejon, Robert W. Snow, Dejan Zurovac   +6 more
doaj   +1 more source

Methodology of assessment and reporting of safety in anti-malarial treatment efficacy studies of uncomplicated falciparum malaria in pregnancy: a systematic literature review

Malaria Journal, 2017
Background Considering the uncertainty of safety of anti-malarial drugs in pregnancy, efficacy studies are one of the few sources of clinical safety data.
Makoto Saito, Mary Ellen Gilder, François Nosten, Philippe J. Guérin, Rose McGready   +4 more
doaj   +1 more source

Monitoring antimalarial safety and tolerability in clinical trials: a case study from Uganda. [PDF]

, 2008
BACKGROUND: New antimalarial regimens, including artemisinin-based combination therapies (ACTs), have been adopted widely as first-line treatment for uncomplicated malaria.
Njama-Meya Denise, Staedke Sarah G, Catherine Maiteki-Sebuguzi, Sarah G Staedke, Denise Njama-Meya, Moses R Kamya, Kristin Banek, Maiteki-Sebuguzi Catherine, Grant Dorsey, Yeka Adoke, Jagannathan, Prasanna, Dorsey, Grant, Talisuna, Ambrose O, Arthur Mpimbaza, Dorsey Grant, Ambrose O Talisuna, Rosenthal Philip J, Hasifa Bukirwa, Jagannathan Prasanna, Maiteki-Sebuguzi, Catherine, Rosenthal, Philip J, Tamara D Clark, Clark Tamara D, Yeka, Adoke, Banek, Kristin, Nzarubara Bridget, Staedke, Sarah G, Prasanna Jagannathan, Banek Kristin, Mpimbaza Arthur, Bukirwa, Hasifa, Nzarubara, Bridget, Philip J Rosenthal, Njama-Meya, Denise, Clark, Tamara D, Adoke Yeka, Mpimbaza, Arthur, Kamya Moses R, Bridget Nzarubara, Kamya, Moses R, Bukirwa Hasifa, Wabwire-Mangen Fred, Talisuna Ambrose O, Fred Wabwire-Mangen, Wabwire-Mangen, Fred   +44 more
core   +1 more source

Systematic literature review and meta-analysis of the efficacy of artemisinin-based and quinine-based treatments for uncomplicated falciparum malaria in pregnancy: methodological challenges

Malaria Journal, 2017
Background There is no agreed standard method to assess the efficacy of anti-malarials for uncomplicated falciparum in pregnancy despite an increased risk of adverse outcomes for the mother and the fetus.
Makoto Saito, Mary Ellen Gilder, François Nosten, Rose McGready, Philippe J. Guérin   +4 more
doaj   +1 more source

In-Vitro Antimalarial Resistance Pattern of Plasmodium Falciparum Infection Among Pregnant Women In Northern Nigeria [PDF]

Afro-Egyptian Journal of Infectious and Endemic Diseases, 2017
Background and study aim: Despite the global priority given to malaria control and prevention, antimalarial resistance is a major factor that encourages persistence of malaria in developing countries.
Anthony Vanstawa, Amos Dangana, Maryam Aliyu, Idris Nasir, Yahaya Umar   +4 more
doaj   +1 more source

Knowledge among Drug Dispensers and Antimalarial Drug Prescribing Practices in Public Health Facilities in Dar es Salaam. [PDF]

, 2013
Irrational prescribing and dispensing of antimalarials has been identified as a contributing factor in the emergence of malaria parasites resistant to existing antimalarial drugs.
Kamuhabwa AA, Silumbe R, Kamuhabwa, Appolinary Ar, Silumbe, Richard   +3 more
core   +1 more source

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

Deprotective Alkylation: A Platform for Alcohol‐to‐Amine Interconversion Using Nonafluoromesitylenesulfonamides

Angewandte Chemie International Edition, EarlyView.
The straightforward conversion of alcohols to tertiary or secondary amines employing Nms‐amides in a single operation is described. The transformation features broad functional group tolerance and high stereospecificity, underscoring its utility in the synthesis of isotope‐labeled pharmaceuticals.
Jakub Brześkiewicz, Kunj Kapur, Boris Maryasin, Nuno Maulide   +3 more
wiley   +1 more source

Antimalarial Drug Resistance and Novel Targets for Antimalarial Drug Discovery.

Infection and drug resistance, 2020
Malaria is among the most devastating and widespread tropical parasitic diseases in which most prevalent in developing countries. Antimalarial drug resistance is the ability of a parasite strain to survive and/or to multiply despite the administration and absorption of medicine given in doses equal to or higher than those usually recommended. Among the
Shibeshi, Melkamu Adigo, Kifle, Zemene Demelash, Atnafie, Seyfe Asrade   +2 more
openaire   +2 more sources