Results 41 to 50 of about 2,234,657 (224)

Optimal health and disease management using spatial uncertainty: a geographic characterization of emergent artemisinin-resistant Plasmodium falciparum distributions in Southeast Asia

International Journal of Health Geographics, 2016
Background Artemisinin-resistant Plasmodium falciparum malaria parasites are now present across much of mainland Southeast Asia, where ongoing surveys are measuring and mapping their spatial distribution. These efforts require substantial resources. Here
Eric P. M. Grist, Jennifer A. Flegg, Georgina Humphreys, Ignacio Suay Mas, Tim J. C. Anderson, Elizabeth A. Ashley, Nicholas P. J. Day, Mehul Dhorda, Arjen M. Dondorp, M. Abul Faiz, Peter W. Gething, Tran T. Hien, Tin M. Hlaing, Mallika Imwong, Jean-Marie Kindermans, Richard J. Maude, Mayfong Mayxay, Marina McDew-White, Didier Menard, Shalini Nair, Francois Nosten, Paul N. Newton, Ric N. Price, Sasithon Pukrittayakamee, Shannon Takala-Harrison, Frank Smithuis, Nhien T. Nguyen, Kyaw M. Tun, Nicholas J. White, Benoit Witkowski, Charles J. Woodrow, Rick M. Fairhurst, Carol Hopkins Sibley, Philippe J. Guerin   +33 more
doaj   +1 more source

Determination of different social groups’ level of knowledge about malaria in a multicultural Amazonian cross-border context

BMC Public Health, 2023
Background A steady decline in the number of cases of malaria was observed in the 2000s in French Guiana. This enabled regional health policies to shift their public health goal from control to elimination.
Mélanie Gaillet, Lise Musset, Claire Cropet, Félix Djossou, Adeline Mallard, Guillaume Odonne, Damien Davy, Maylis Douine, Loic Epelboin, Yassamine Lazrek, Luana Mathieu, Mathieu Nacher, Emilie Mosnier   +12 more
doaj   +1 more source

"Plasmodium falciparum" Drug Resistance, Molecular Genotyping and Generation of a Malaria Resistance Genogram by DNA Microarray-Based Technology [PDF]

, 2006
Prior to the 2001 malarial treatment policy change in Tanzania, studies were conducted to assess the efficacy of sulfadoxine-pyrimethamine (SP) and usefulness of molecular markers in monitoring SP resistance.
Mugittu, Kefas Nasongelya
core   +1 more source

Making data map-worthy—enhancing routine malaria data to support surveillance and mapping of Plasmodium falciparum anti-malarial resistance in a pre-elimination sub-Saharan African setting: a molecular and spatiotemporal epidemiology study

Malaria Journal, 2022
Background Independent emergence and spread of artemisinin-resistant Plasmodium falciparum malaria have recently been confirmed in Africa, with molecular markers associated with artemisinin resistance increasingly detected.
Frank M. Kagoro, Elizabeth Allen, Aaron Mabuza, Lesley Workman, Ray Magagula, Gerdalize Kok, Craig Davies, Gillian Malatje, Philippe J. Guérin, Mehul Dhorda, Richard J. Maude, Jaishree Raman, Karen I. Barnes   +12 more
doaj   +1 more source

Different methodological approaches to the assessment of in vivo efficacy of three artemisinin-based combination antimalarial treatments for the treatment of uncomplicated falciparum malaria in African children. [PDF]

, 2008
BACKGROUND: Use of different methods for assessing the efficacy of artemisinin-based combination antimalarial treatments (ACTs) will result in different estimates being reported, with implications for changes in treatment policy.
Pinoges Loretxu, Balkan, S, Grant Dorsey, Pinoges, Loretxu, Hasifa Burkirwa, Olliaro, P, Pedro Pablo Palma Urruta, Checchi, Francesco, Ingrid van den Broek, Dorsey Grant, Urruta, P P P, Walter R Taylor, Michel van Herp, Ashley Elizabeth A, Dorsey, G, van Herp Michel, Turyakira, Eleanor, Guthmann, Jean-Paul, Ashley, Elizabeth A, Zongo Issaka, Taylor Walter R, van Herp, M, Francesco Checchi, Issaka Zongo, Turyakira, E, Zongo, I, Taylor, W R J, Balkan Suna, Dorsey, Grant, van den Broek Ingrid, van Herp, Michel, Ashley, E A, van den Broek, Ingrid, Taylor, Walter R, Urruta, Pedro Pablo Palma, Elizabeth A Ashley, Eleanor Turyakira, Olliaro Piero, Pinoges, L, Jean-Paul Guthmann, Guthmann, J P, Guthmann Jean-Paul, van den Broek, I, Piero Olliaro, Zongo, Issaka, Checchi Francesco, Bukirwa, H, Checchi, F, Loretxu Pinoges, Bukirwa, Hasifa, Turyakira Eleanor, Suna Balkan, Bukirwa Hasifa, Urruta Pedro, Balkan, Suna, Olliaro, Piero   +55 more
core   +1 more source

Investigating the relationship between Pfkelch13 mutations and response to artemisinin-based treatment for uncomplicated falciparum malaria: a protocol for a systematic review and individual patient data meta-analysis

BMJ Open
Introduction Artemisinin-based combination therapies (ACTs) remain the WHO-recommended treatment for uncomplicated Plasmodium falciparum malaria. However, the emergence and spread of artemisinin resistance (ART-R) threatens ACT efficacy.
Prabin Dahal, Philippe Guerin, Farhad Shokraneh, James A Watson, Karen I Barnes, Aboubakar Soma, Stephanie van Wyk, Chistevy Vouvoungui, Dhol S Ayuen   +8 more
doaj   +1 more source

Population biology and antimalarial resistance: The transmission of antimalarial drug resistance in Plasmodium falciparum

Acta Tropica, 2005
Malaria morbidity and mortality continue to increase across sub-Saharan Africa. This is largely as a result of the continued use of chloroquine and sulfadoxine-pyrimethamine, despite widespread resistance. Although eliminating the asexual stages of Plasmodium falciparum is the focus of treatment of individual symptomatic patients, at a population level,
Barnes, K, White, N
openaire   +2 more sources

Superinfection and the evolution of resistance to antimalarial drugs [PDF]

Proceedings of the Royal Society B: Biological Sciences, 2012
A major issue in the control of malaria is the evolution of drug resistance. Ecological theory has demonstrated that pathogen superinfection and the resulting within-host competition influences the evolution of specific traits. Individuals infected with Plasmodium falciparum are consistently infected by multiple ...
Eili Y, Klein, David L, Smith, Ramanan, Laxminarayan, Simon, Levin   +3 more
openaire   +2 more sources

Molecular Profiles of Multiple Antimalarial Drug Resistance Markers in Plasmodium falciparum and Plasmodium vivax in the Mandalay Region, Myanmar

Microorganisms, 2022
Emergence and spreading of antimalarial drug resistant malaria parasites are great hurdles to combating malaria. Although approaches to investigate antimalarial drug resistance status in Myanmar malaria parasites have been made, more expanded studies are
Hương Giang Lê, Haung Naw, Jung-Mi Kang, Tuấn Cường Võ, Moe Kyaw Myint, Zaw Than Htun, Jinyoung Lee, Won Gi Yoo, Tong-Soo Kim, Ho-Joon Shin, Byoung-Kuk Na   +10 more
doaj   +1 more source

Transporters involved in resistance to antimalarial drugs [PDF]

Trends in Pharmacological Sciences, 2006
The ability to treat and control Plasmodium falciparum infection through chemotherapy has been compromised by the advent and spread of resistance to antimalarial drugs. Research in this area has identified the P. falciparum chloroquine resistance transporter (PfCRT) and the multidrug resistance-1 (PfMDR1) transporter as key determinants of decreased in
Stephanie G, Valderramos, David A, Fidock   +1 more
openaire   +2 more sources