Results 31 to 40 of about 2,234,657 (224)

Artemether-lumefantrine treatment of uncomplicated Plasmodium falciparum malaria : a systematic review and meta-analysis of day 7 lumefantrine concentrations and therapeutic response using individual patient data [PDF]

, 2015
Achieving adequate antimalarial drug exposure is essential for curing malaria. Day 7 blood or plasma lumefantrine concentrations provide a simple measure of drug exposure that correlates well with artemether-lumefantrine efficacy.
Mårtensson, A, Sibley, CH, Nsanzabana, C, Bassat, Q, Ringwald, P, Faucher, JF, WorldWide Antimalarial Resistance Network Lumefantrine PK/PD Stu,, Ashley, EA, Hodel, EM, Lindegardh, NL, Davis, TME, Schramm, B, Lefèvre, G, Parikh, S, Mayxay, M, Van Vugt, M, Borrmann, S, McGready, R, Hamed, K, Jullien, V, Workman, LJ, Newton, PN, Stepniewska, K, Vugt, MV, Genton, B, Kiechel, JR, Rombo, L, White, Nicholas, Price, Richard, Kofoed, PE, Piola, P, Barnes, KI, Dahal, P, Aweeka, F, Moreira, C, Tarning, J, Nosten, F, Djimde, AA, Ursing, J, Ngasala, BE, Deloron, P, Karunajeewa, HA, Guérin, PJ, Denis, MB, Marsh, K, WorldWide Antimalarial Resistance Network (WWARN) Lumefantrine PK/PD Study Group, Price, RN, Lindegardh, N, White, NJ, Huang, L, McGready, Rose   +50 more
core   +1 more source

Molecular markers of resistance to amodiaquine plus sulfadoxine–pyrimethamine in an area with seasonal malaria chemoprevention in south central Niger

Malaria Journal, 2018
Background In Niger, malaria transmission is markedly seasonal with most of the disease burden occurring in children during the rainy season. Seasonal malaria chemoprevention (SMC) with amodiaquine plus sulfadoxine–pyrimethamine (AQ + SP) is recommended ...
Rebecca F. Grais, Ibrahim M. Laminou, Lynda Woi-Messe, Rockyath Makarimi, Seidou H. Bouriema, Celine Langendorf, Alfred Amambua-Ngwa, Umberto D’Alessandro, Philippe J. Guérin, Thierry Fandeur, Carol H. Sibley   +10 more
doaj   +1 more source

Assessing antimalarial efficacy in a time of change to artemisinin-based combination therapies: the role of Médecins Sans Frontières. [PDF]

, 2008
Jean-Paul Guthmann and colleagues describe the output of MSF's work in antimalarial efficacy assessment during the last ...
Comte, Eric, Legros, Dominique, Francesco Checchi, Guthmann, JP, Balkan, S, Philippe J Guerin, Balkan Suna, Kindermans Jean-Marie, Legros, D, van den Broek Ingrid, Guerin Philippe J, van Herp, Michel, van den Broek, Ingrid, Checchi, Francesco, Ingrid van den Broek, Oscar Bernal, Guerin, Philippe J, Jean-Marie Kindermans, Dominique Legros, Jean-Paul Guthmann, Guerin, PJ, Comte Eric, Kindermans, JM, Michel van Herp, Guthmann Jean-Paul, Venis Sarah, van den Broek, I, Sarah Venis, Kindermans, Jean-Marie, van Herp Michel, Checchi Francesco, Comte, E, Checchi, F, Bernal, O, Guthmann, Jean-Paul, Legros Dominique, Eric Comte, Guerin, Philippe, Venis, Sarah, Suna Balkan, Venis, S, Bernal Oscar, Balkan, Suna, van Herp, M, Bernal, Oscar   +44 more
core   +1 more source

Polymorphisms in Plasmodium falciparum chloroquine resistance transporter and multidrug resistance 1 genes: parasite risk factors that affect treatment outcomes for P. falciparum malaria after artemether-lumefantrine and artesunate-amodiaquine. [PDF]

, 2014
Adequate clinical and parasitologic cure by artemisinin combination therapies relies on the artemisinin component and the partner drug. Polymorphisms in the Plasmodium falciparum chloroquine resistance transporter (pfcrt) and P.
Kamugisha, Erasmus, Piola, Patrice, Faucher, Jean-François, El-Sayed, Badria, Houzé, Sandrine, Somé, A Fabrice, Sutherland, Colin, Checchi, Francesco, Plowe, Christopher, V, Sutherland, Colin J, Otienoburu, Sabina Dahlström, Berens-Riha, Nicole, Grivoyannis, Anastasia, Davis, Timothy ME, Björkman, Anders, Asaq Molecular Marker Study Group, Rosenthal, Philip, Eyase, Frederick, Malmberg, Maja, Kariuki, Simon, Mårtensson, Andreas,, Hamour, Sally, Ogutu, Bernhards, Davis, Timothy, Wong, Rina, Sibley, Carol Hopkins, Gadalla, Nahla B, Ngasala, Billy, Ménard, Didier, Oguike, Mary, Venkatesan, Meera, Arze, Cesar, Djimdé, Abdoulaye A, Baliraine, Frederick N, Fröberg, Gabrielle, Ursing, Johan, LeBras, Jacques, Desai, Meghna, Mårtensson, Andreas, Ouédraogo, Jean-Bosco, El-Sayed, Badria B, Mwai, Leah, Thwing, Julie, Kironde, Fred, Djimde, Abdoulaye, Price, Ric, Dorsey, Grant, Johnson, Jacob, Guérin, Philippe, Somé, A. Fabrice, Oguike, Alexis Nzila Mary, LeBras, Poul-Erik Kofoed Jacques, Moriera, Clarissa, Kiechel, Jean-René, Kofoed, Poul-Erik, Dahal, Prabin, Nsanzabana, Christian, Nzila, Alexis, Wong, Rina PM, Rosenthal, Philip J, Ademowo, George, Falade, Catherine, Nsobya, Samuel L, Schramm, Birgit, Zongo, Issaka, Gadalla, Nahla, Wong, Rina P M, Plowe, Christopher V, Eshetu, Teferi, Davis, Timothy M E, Dhorda, Meghna Desai Mehul, Plowe, Christopher,, Rombo, Lars,, Dhorda, Mehul, Stepniewska, Kasia, Adam, Ishag, Price, Ric N, Borrmann, Steffen, Nosten, Francois, Rombo, Lars, Baliraine, Frederick, Zeynudin, Ahmed, Nsobya, Samuel   +82 more
core   +1 more source

Screening of Traditionally Used Plants for in Vivo Antimalarial Activity in Mice. [PDF]

, 2009
Aqueous ethanol (80%) extracts of six plants used traditionally for treatment of malaria, Vepris glomerata (F.Hoffm.) Engl (Rutaceae), Maranthus floribunda (Bak.) F.White (Chrysobalanaceae), Strophanthus eminii Asch.
Mbwambo, Zakaria H., Kapingu, Modest C., P Masimba, Masimba, Pax J., Mbwambo, Zakaria H, Moshi, M.J., Moshi, M, Kamuhabwa, A, M Moshi, E Innocent, Innocent, E., Innocent, E, Masimba, P, Kapingu, M, Kamuhabwa, A., Kapingu, M.C., Moshi, Mainen J., Masimba, Pax J, Moshi, Mainen J, Kamuhabwa, Appolinary, Mbwambo, Z, A Kamuhabwa, M Kapingu, Innocent, Esther, Mbwambo, Z.H., Kapingu, Modest C, Masimba, P.J., Z Mbwambo   +27 more
core   +1 more source

Safety of single-dose primaquine as a Plasmodium falciparum gametocytocide: a systematic review and meta-analysis of individual patient data

BMC Medicine, 2022
Background In 2012, the World Health Organization (WHO) recommended single low-dose (SLD, 0.25 mg/kg) primaquine to be added as a Plasmodium (P.) falciparum gametocytocide to artemisinin-based combination therapy (ACT) without glucose-6-phosphate ...
Kasia Stepniewska, Elizabeth N. Allen, Georgina S. Humphreys, Eugenie Poirot, Elaine Craig, Kalynn Kennon, Daniel Yilma, Teun Bousema, Philippe J. Guerin, Nicholas J. White, Ric N. Price, Jaishree Raman, Andreas Martensson, Richard O. Mwaiswelo, Germana Bancone, Guido J. H. Bastiaens, Anders Bjorkman, Joelle M. Brown, Umberto D’Alessandro, Alassane A. Dicko, Badria El-Sayed, Salah-Eldin Elzaki, Alice C. Eziefula, Bronner P. Gonçalves, Muzamil Mahdi Abdel Hamid, Akira Kaneko, Simon Kariuki, Wasif Khan, Titus K. Kwambai, Benedikt Ley, Billy E. Ngasala, Francois Nosten, Joseph Okebe, Aaron M. Samuels, Menno R. Smit, Will J. R. Stone, Inge Sutanto, Feiko Ter Kuile, Roger C. Tine, Alfred B. Tiono, Chris J. Drakeley, Roly Gosling, Andy Stergachis, Karen I. Barnes, Ingrid Chen   +44 more
doaj   +1 more source

Antimalarial drug resistance: An overview

Tropical Parasitology, 2016
Malaria is a major public health burden throughout the world. Resistance to the antimalarial drugs has increased the mortality and morbidity rate that is achieved so far through the malaria control program. Monitoring the drug resistance to the available antimalarial drugs helps to implement effective drug policy, through the in vivo efficacy studies ...
Antony, Hiasindh Ashmi, Parija, Subhash Chandra   +1 more
openaire   +3 more sources

The Vivax Surveyor: Online mapping database for Plasmodium vivax clinical trials

International Journal for Parasitology: Drugs and Drug Resistance, 2017
Introduction: Recurrent P. vivax infections are associated with significant morbidity and mortality. Although radical cure can reduce recurrent infection, it is confounded by antimalarial resistance and the lack of safe and effective hypnozoitocidal ...
R.J. Commons, K. Thriemer, G. Humphreys, I. Suay, C.H. Sibley, P.J. Guerin, R.N. Price   +6 more
doaj   +1 more source

Factors influencing health workers’ compliance with outpatient malaria ‘test and treat’ guidelines during the plateauing performance phase in Kenya, 2014–2016

Malaria Journal, 2022
Background Health workers’ compliance with outpatient malaria ‘test and treat’ guidelines has improved since 2010 but plateaued from 2014 at suboptimal levels in Kenya. This study examined the factors associated with high but suboptimal compliance levels
Beatrice Amboko, Kasia Stepniewska, Beatrice Machini, Philip Bejon, Robert W. Snow, Dejan Zurovac   +5 more
doaj   +1 more source

The arrhythmogenic cardiotoxicity of the quinoline and structurally related antimalarial drugs: a systematic review

BMC Medicine, 2018
Background Several quinoline and structurally related antimalarial drugs are associated with cardiovascular side effects, particularly hypotension and electrocardiographic QT interval prolongation.
Ilsa L. Haeusler, Xin Hui S. Chan, Philippe J. Guérin, Nicholas J. White   +3 more
doaj   +1 more source