Results 21 to 30 of about 2,234,657 (224)

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

The rationale and plan for creating a World Antimalarial Resistance Network (WARN) [PDF]

, 2007
Drug resistant malaria was a major factor contributing to the failure of a worldwide campaign to eradicate malaria in the last century, and now threatens the large investment being made by the global community in the rollout of effective new drug ...
Barnes, Karen I., Karen I Barnes, Christopher V Plowe, Carol Sibley, Barnes, Karen I, Plowe, Christopher V., Sibley, Carol Hopkins, Plowe, Christopher V, Plowe Christopher V, Sibley Carol, Barnes Karen I   +10 more
core   +1 more source

An online mapping database of molecular markers of drug resistance in Plasmodium falciparum: the ACT Partner Drug Molecular Surveyor

Malaria Journal, 2019
Background Prior to this project, only a handful of online visualizations existed for exploring the published literature on molecular markers of antimalarial drug resistance, and none specifically for the markers associated with Plasmodium falciparum ...
Sabina Dahlström Otienoburu, Ignacio Suay, Steven Garcia, Nigel V. Thomas, Suttipat Srisutham, Anders Björkman, Georgina S. Humphreys   +6 more
doaj   +1 more source

World Antimalarial Resistance Network (WARN) III: Molecular markers for drug resistant malaria [PDF]

, 2007
Molecular markers for drug resistant malaria represent public health tools of great but mostly unrealized potential value. A key reason for the failure of molecular resistance markers to live up to their potential is that data on the their prevalence is ...
Sibley, CH, Happi Christian T, Mbacham, W, Mugittu, K, Sutherland Colin J, Zimmerman, Peter A., Joshi, HH, Barnwell, JW, Naidoo, I, Happi, Christian T., Sutherland, Colin J, Sibley Carol H, Price Ric N, Mbacham, Wilfred, Happi, Christian T, Rosenthal Philip J, Barnwell, John W., Meshnick, Steven R, Shafer, RW, Plowe, CV, Roper, Cally, Zimmerman, PA, Sibley, Carol Hopkins, Shafer, Robert W, Barnwell John W, Barnwell, John W, Meshnick Steven R, Shafer, Robert W., Naidoo Inbarani, Sibley, Carol H, Joshi, Hema H., Sutherland, CJ, Meshnick, SR, Shafer Robert W, Rosenthal, Phillip J., Happi, CT, Rosenthal, PJ, Plowe Christopher V, Joshi, Hema H, Plowe, Christopher V., Rosenthal, Philip J, Mugittu Kefas, Roper Cally, Meshnick, Steven R., Zimmerman, Peter A, Sutherland, Colin J., Price, Ric N., Plowe, Christopher V, Mugittu, Kefas, Mbacham Wilfred, Naidoo, Inbarani, Price, RN, Price, Ric N, Zimmerman Peter A, Roper, C, Joshi Hema H, Happi, Christian, Zimmerman, Peter   +57 more
core   +1 more source

Complex interactions between malaria and malnutrition: a systematic literature review

BMC Medicine, 2018
Background Despite substantial improvement in the control of malaria and decreased prevalence of malnutrition over the past two decades, both conditions remain heavy burdens that cause hundreds of thousands of deaths in children in resource-poor ...
D Das, R F Grais, E A Okiro, K Stepniewska, R Mansoor, S van der Kam, D J Terlouw, J Tarning, K I Barnes, P J Guerin   +9 more
doaj   +1 more source

A novel antimalarial lead compound: in vitro properties and mode of action studies [PDF]

, 2011
Malaria remains a major public health problem and the increasing number of resistant strains underscores the need for new drugs with new modes of action (MOAs).
Brunner, Ralf Oskar
core   +1 more source

Dealing with indeterminate outcomes in antimalarial drug efficacy trials: a comparison between complete case analysis, multiple imputation and inverse probability weighting

BMC Medical Research Methodology, 2019
Background Antimalarial clinical efficacy studies for uncomplicated Plasmodium falciparum malaria frequently encounter situations in which molecular genotyping is unable to discriminate between parasitic recurrence, either new infection or recrudescence.
Prabin Dahal, Kasia Stepniewska, Philippe J. Guerin, Umberto D’Alessandro, Ric N. Price, Julie A. Simpson   +5 more
doaj   +1 more source

The perils of PCR: can we accurately 'correct' antimalarial trials? [PDF]

, 2010
During follow-up in antimalarial drug trials, treated subjects can be newly infected. PCR correction is used to distinguish this re-infection from drug failure (recrudescence) and to adjust final drug efficacy estimates.
Sutherland, Colin J, Juliano, Jonathan J, Gadalla, Nahla, Meshnick, Steven R., Meshnick, Steven R, Juliano, Jonathan J., Sutherland, Colin J.   +6 more
core   +1 more source

Statistical methods to derive efficacy estimates of anti-malarials for uncomplicated Plasmodium falciparum malaria: pitfalls and challenges

Malaria Journal, 2017
The Kaplan–Meier (K–M) method is currently the preferred approach to derive an efficacy estimate from anti-malarial trial data. In this approach event times are assumed to be continuous and estimates are generated on the assumption that there is only one
Prabin Dahal, Julie A. Simpson, Grant Dorsey, Philippe J. Guérin, Ric N. Price, Kasia Stepniewska   +5 more
doaj   +1 more source

The effect of dose on the antimalarial efficacy of artesunate-mefloquine against Plasmodium falciparum malaria: a protocol for systematic review and individual patient data (IPD) meta-analysis

BMJ Open, 2019
IntroductionAntimalarial posology based on weight bands leaves patients at the margins vulnerable to receiving either lower or higher weight-adjusted (mg/kg) dosages. This article aims to describe the protocol for systematic review and individual patient
Prabin Dahal, Philippe Guerin, Elizabeth A Ashley   +2 more
doaj   +1 more source