Results 1 to 10 of about 27,207 (159)

Resistance to Antimalarial Monotherapy Is Cyclic [PDF]

Journal of Clinical Medicine, 2022
Malaria is a prevalent parasitic disease that is estimated to kill between one and two million people—mostly children—every year. Here, we query PubMed for malaria drug resistance and plot the yearly citations of 14 common antimalarials. Remarkably, most antimalarial drugs display cyclic resistance patterns, rising and falling over four decades.
Abraham O Samson, Trishna Saha Detroja, Ortal Calfon-Peretz   +2 more
exaly   +3 more sources

Haematological consequences of acute uncomplicated falciparum malaria: a WorldWide Antimalarial Resistance Network pooled analysis of individual patient data [PDF]

BMC Medicine, 2022
Background Plasmodium falciparum malaria is associated with anaemia-related morbidity, attributable to host, parasite and drug factors. We quantified the haematological response following treatment of uncomplicated P.
The WorldWide Antimalarial Resistance Network Falciparum Haematology Study Group
doaj   +2 more sources

Variability in white blood cell count during uncomplicated malaria and implications for parasite density estimation: a WorldWide Antimalarial Resistance Network individual patient data meta-analysis [PDF]

Malaria Journal, 2023
Background The World Health Organization (WHO) recommends that when peripheral malarial parasitaemia is quantified by thick film microscopy, an actual white blood cell (WBC) count from a concurrently collected blood sample is used in calculations ...
WorldWide Antimalarial Resistance Network White Blood Cell Count in Malaria Study Group
doaj   +2 more sources

Targeting Plasmodium falciparum Hsp90: Towards Reversing Antimalarial Resistance

Pathogens, 2013
Malaria continues to exact a great human toll in tropical settings. Antimalarial resistance is rife and the parasite inexorably develops mechanisms to outwit our best drugs, including the now first-line choice, artesunate.
Dea Shahinas, Asongna Folefoc, Dylan R. Pillai   +2 more
doaj   +3 more sources

Application of a new highly multiplexed amplicon sequencing tool to evaluate Plasmodium falciparum antimalarial resistance and relatedness in individual and pooled samples from Dschang, Cameroon [PDF]

Frontiers in Parasitology
BackgroundResistance to antimalarial drugs remains a major obstacle to malaria elimination. Multiplexed, targeted amplicon sequencing is being adopted for surveilling resistance and dissecting the genetics of complex malaria infections.
Jacob M. Sadler, Alfred Simkin, Valery P. K. Tchuenkam, Isabela Gerdes Gyuricza, Isabela Gerdes Gyuricza, Abebe A. Fola, Kevin Wamae, Ashenafi Assefa, Ashenafi Assefa, Karamoko Niaré, Kyaw Thwai, Samuel J. White, William J. Moss, Rhoel R. Dinglasan, Sandrine Eveline Nsango, Christopher B. Tume, Jonathan B. Parr, Jonathan B. Parr, Jonathan B. Parr, Innocent Mbulli Ali, Jeffrey A. Bailey, Jeffrey A. Bailey, Jonathan J. Juliano, Jonathan J. Juliano, Jonathan J. Juliano, Jonathan J. Juliano   +25 more
doaj   +2 more sources

How to tackle antimalarial resistance? [PDF]

EMBO Mol Med, 2017
In the context of drug resistance, malaria is no exception. Even the latest artemisinins have started to lose their full efficacy in patients. Didier Leroy tells us about the strategies adopted by Medicines for Malaria Venture to reduce this terrible culprit. [Image: see text]
Leroy D.
europepmc   +4 more sources

The Impact of Antimalarial Use on the Emergence and Transmission of Plasmodium falciparum Resistance: A Scoping Review of Mathematical Models

Tropical Medicine and Infectious Disease, 2017
The emergence and transmission of resistance to antimalarial treatments continue to hamper malaria elimination efforts. A scoping review was undertaken regarding the impact of antimalarial treatment in the human population on the emergence and ...
Aleisha R. Brock, Carole A. Gibbs, Joshua V. Ross, Adrian Esterman   +3 more
doaj   +3 more sources

Antimalarial Drug Resistance: A Brief History of Its Spread in Indonesia

Drug Design, Development and Therapy, 2023
Loeki Enggar Fitri,1,2 Aulia Rahmi Pawestri,1,2 Nuning Winaris,1,2 Agustina Tri Endharti,1 Alif Raudhah Husnul Khotimah,3,4 Hafshah Yasmina Abidah,3,4 John Thomas Rayhan Huwae3,5 1Department of Parasitology Faculty of Medicine, Universitas Brawijaya ...
Fitri LE, Pawestri AR, Winaris N, Endharti AT, Khotimah ARH, Abidah HY, Huwae JTR   +6 more
doaj   +2 more sources

Molecular surveillance for operationally relevant genetic polymorphisms in Plasmodium falciparum in Southern Chad, 2016–2017

Malaria Journal, 2022
Background Resistance to anti-malarials is a serious threat to the efforts to control and eliminate malaria. Surveillance based on simple field protocols with centralized testing to detect molecular markers associated with anti-malarial drug resistance ...
Sukanta Das, Clément Kérah-Hinzoumbé, Moundiné Kebféné, Suttipat Srisutham, Tog-Yeum Nagorngar, Naowarat Saralamba, Ranitha Vongpromek, Teeradet Khomvarn, Carol H. Sibley, Philippe J. Guérin, Mallika Imwong, Mehul Dhorda   +11 more
doaj   +1 more source

Temporal distribution of Plasmodium falciparum recrudescence following artemisinin-based combination therapy: an individual participant data meta-analysis

Malaria Journal, 2022
Background The duration of trial follow-up affects the ability to detect recrudescent infections following anti-malarial treatment. The aim of this study was to explore the proportions of recrudescent parasitaemia as ascribed by genotyping captured at ...
The WorldWide Antimalarial Resistance Network Methodology Study Group
doaj   +1 more source