Results 11 to 20 of about 2,234,657 (224)

Competing risk events in antimalarial drug trials in uncomplicated Plasmodium falciparum malaria: a WorldWide Antimalarial Resistance Network individual participant data meta-analysis [PDF]

Malaria Journal, 2019
Background Therapeutic efficacy studies in uncomplicated Plasmodium falciparum malaria are confounded by new infections, which constitute competing risk events since they can potentially preclude/pre-empt the detection of subsequent recrudescence of ...
The WorldWide Antimalarial Resistance Network Methodology Study Group
doaj   +4 more sources

World Antimalarial Resistance Network I: Clinical efficacy of antimalarial drugs [PDF]

Malaria Journal, 2007
يتيح انتشار تجارب الأدوية المضادة للملاريا في السنوات العشر الماضية الفرصة لإطلاق جهد ترصد عالمي منسق لرصد فعالية الأدوية المضادة للملاريا. إن تنوع تصاميم الدراسات السريرية والأساليب التحليلية يقوض القدرة الحالية على تحقيق ذلك. تهدف الشبكة العالمية المقترحة لمقاومة الملاريا (WARN) إلى إنشاء قاعدة بيانات سريرية شاملة يمكن من خلالها استخلاص تقديرات موحدة
Ric N. Price, Grant Dorsey, Elizabeth A. Ashley, Karen I. Barnes, J. Kevin Baird, Umberto D'Alessandro, Philippe J Guerin, Miriam K. Laufer, Inbarani Naidoo, François Nosten, Piero Olliaro, Christopher V. Plowe, Pascal Ringwald, Carol Hopkins Sibley, Kasia Stepniewska, Nicholas J. White   +15 more
openaire   +8 more sources

The effect of dosing regimens on the antimalarial efficacy of dihydroartemisinin-piperaquine: a pooled analysis of individual patient data. [PDF]

PLoS Medicine, 2013
BackgroundDihydroartemisinin-piperaquine (DP) is increasingly recommended for antimalarial treatment in many endemic countries; however, concerns have been raised over its potential under dosing in young children.
WorldWide Antimalarial Resistance Network (WWARN) DP Study Group
doaj   +2 more sources

The threat of antimalarial drug resistance [PDF]

Tropical Diseases, Travel Medicine and Vaccines, 2016
La bataille entre l'homme et le paludisme se poursuit depuis des milliers d'années. Les médicaments antipaludiques sont des armes essentielles pour lutter contre la maladie, mais leur efficacité est menacée par la résistance aux médicaments qui continue d'émerger, créant un obstacle majeur à la lutte antipaludique et compromettant les espoirs ...
Borimas Hanboonkunupakarn, Nicholas J. White   +1 more
openaire   +2 more sources

A database of antimalarial drug resistance [PDF]

Malaria Journal, 2006
A large investment is required to develop, license and deploy a new antimalarial drug. Too often, that investment has been rapidly devalued by the selection of parasite populations resistant to the drug action. To understand the mechanisms of selection, detailed information on the patterns of drug use in a variety of environments, and the geographic ...
Sibley, Carol Hopkins, Ringwald, Pascal
openaire   +4 more sources

Molecular detection of human Plasmodium species using a multiplex real time PCR

Scientific Reports, 2023
Molecular detection methods have revealed higher sensitivity and specificity than conventional microscopy or rapid diagnostic tests for malaria diagnosis.
Yassamine Lazrek, Célia Florimond, Béatrice Volney, Manon Discours, Emilie Mosnier, Sandrine Houzé, Stéphane Pelleau, Lise Musset   +7 more
doaj   +1 more source

The efficacy of antimalarial monotherapies, sulphadoxine-pyrimethamine and amodiaquine in East Africa: implications for sub-regional policy. [PDF]

, 2003
Between 1998 and 2001, Kenya, Uganda, Tanzania, Zanzibar, Rwanda and Burundi changed antimalarial drug policy, in the face of widespread chloroquine resistance.
East African Network for Monitoring Antimalarial Treatment (EANMAT), East African Network for Monitoring Antimalarial Treatment (EANM   +1 more
core   +1 more source

Evaluating antimalarial efficacy in single-armed and comparative drug trials using competing risk survival analysis: a simulation study

BMC Medical Research Methodology, 2019
Background Antimalarial efficacy studies in patients with uncomplicated Plasmodium falciparum are confounded by a new infection (a competing risk event) since this event can potentially preclude a recrudescent event (primary endpoint of interest).
Prabin Dahal, Philippe J. Guerin, Ric N. Price, Julie A. Simpson, Kasia Stepniewska   +4 more
doaj   +1 more source

Mapping genetic markers of artemisinin resistance in Plasmodium falciparum malaria in Asia: a systematic review and spatiotemporal analysis

The Lancet Microbe, 2022
Summary: Background: The increase in artemisinin resistance threatens malaria elimination in Asia by the target date of 2030 and could derail control efforts in other endemic regions.
Frank M Kagoro, MSc, Karen I Barnes, ProfMMed, Kevin Marsh, ProfMBChB, Nattwut Ekapirat, MSc, Chris Erwin G Mercado, MSc, Ipsita Sinha, MSc, Georgina Humphreys, PhD, Mehul Dhorda, PhD, Philippe J Guerin, ProfMD, Richard J Maude, ProfDPhil   +9 more
doaj   +1 more source

Antimalarial drug resistance [PDF]

Journal of Clinical Investigation, 2004
Malaria, the most prevalent and most pernicious parasitic disease of humans, is estimated to kill between one and two million people, mainly children, each year. Resistance has emerged to all classes of antimalarial drugs except the artemisinins and is responsible for a recent increase in malaria-related mortality, particularly in Africa.
openaire   +4 more sources