Results 221 to 230 of about 63,797 (281)
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Update on antimalarials and systemic lupus erythematosus
Current Opinion in Rheumatology, 2020Purpose of review The purpose of this review is highlighting the most recent evidence on the clinical efficacy and toxicity of antimalarials in systemic lupus erythematosus (SLE).
G. Ruiz‐Irastorza +2 more
semanticscholar +1 more source
Current Opinion in Pharmacology, 2018
Over the past decade, new high-throughput phenotypic assays with malaria parasites have been developed, and these were used to screen millions of compounds. This effort, as well as improving older chemical scaffolds and optimising compounds against both known and new drug targets has resulted in the discovery of exciting new pipeline drug candidates ...
Rob, Hooft van Huijsduijnen +1 more
openaire +2 more sources
Over the past decade, new high-throughput phenotypic assays with malaria parasites have been developed, and these were used to screen millions of compounds. This effort, as well as improving older chemical scaffolds and optimising compounds against both known and new drug targets has resulted in the discovery of exciting new pipeline drug candidates ...
Rob, Hooft van Huijsduijnen +1 more
openaire +2 more sources
The development process for discovery and clinical advancement of modern antimalarials.
Journal of Medicinal Chemistry, 2019Malaria is a devastating disease caused by Plasmodium parasites resulting in approximately 435,000 deaths in 2018. The impact of malaria is compounded by the emergence of widespread resistance to current antimalarial therapies.
T. Ashton +7 more
semanticscholar +1 more source
The Lancet, 2004
Multidrug resistance has rendered monotherapy for malaria useless in most parts of the world, and has also compromised the usefulness of many of the available combination chemotherapies. New antimalarial regimens are, therefore, urgently needed. We review the various antimalarial combinations that can be used to treat otherwise drug-resistant disease ...
Peter Gottfried, Kremsner +1 more
openaire +2 more sources
Multidrug resistance has rendered monotherapy for malaria useless in most parts of the world, and has also compromised the usefulness of many of the available combination chemotherapies. New antimalarial regimens are, therefore, urgently needed. We review the various antimalarial combinations that can be used to treat otherwise drug-resistant disease ...
Peter Gottfried, Kremsner +1 more
openaire +2 more sources
Journal of the American Academy of Dermatology, 1981
The antimalarials, chloroquine, hydroxychloroquine, and quinacrine, are used primarily for malaria; but they can be beneficial for cutaneous lupus erythematosus (LE), polymorphous light eruption, solar urticaria, and porphyria cutanea tarda. Antimalarials bind to deoxyribonucleic acid (DNA) which prevents DNA and ribonucleic acid (RNA) polymerase ...
openaire +2 more sources
The antimalarials, chloroquine, hydroxychloroquine, and quinacrine, are used primarily for malaria; but they can be beneficial for cutaneous lupus erythematosus (LE), polymorphous light eruption, solar urticaria, and porphyria cutanea tarda. Antimalarials bind to deoxyribonucleic acid (DNA) which prevents DNA and ribonucleic acid (RNA) polymerase ...
openaire +2 more sources
Glucocorticoids and antimalarials in systemic lupus erythematosus: an update and future directions
Current Opinion in Rheumatology, 2018Purpose of review The purpose of this review is highlighting the most recent evidence on the clinical efficacy and toxicity of glucocorticoids and antimalarials in systemic lupus erythematosus (SLE) and provide recommendations on their current use ...
A. Ugarte +2 more
semanticscholar +1 more source
Antimalarials in rheumatic diseases
Baillière's Clinical Rheumatology, 1990The antimalarials hydroxychloroquine and chloroquine remain established and effective agents for the treatment of rheumatoid arthritis and systemic lupus erythematosus. Although the mechanisms of action remain uncertain, evidence is accumulating that the antirheumatic and immunological effects of the antimalarials are related to their massive ...
Tett, S, Cutler, D, Day, R
openaire +5 more sources
Synthetic peroxides as antimalarials
Medicinal Research Reviews, 2004AbstractThe discovery of artemisinin in 1971 initiated a new era in antimalarial chemotherapy. Although the clinically useful semisynthetic artemisinin derivatives are rapid acting and potent antimalarial drugs, they have short half‐lives and must be administered over a period of 5–7 days, leading to noncompliance and recrudescence.
Yuanqing, Tang +2 more
openaire +3 more sources