Results 241 to 250 of about 91,276 (376)

Reaction of N‐Ferrocenylcarbamates with Nitric Oxide: An Application for Detection of Inflammatory Sites In Vivo

ChemMedChem, Volume 20, Issue 19, October 6, 2025.
Nitric oxide induces decomposition of electron‐deficient aminoferrocene drugs 4 with formation of oxime 7, which is derived from the upper cyclopentadienyl ligand. Drugs 4 are not responsive to hydrogen peroxide. Based on the latter reaction, the fluorogenic probes are developed for detecting NO in cells and inflammation in vivo.
Roman Selin, Hülya Gizem Özkan, Galyna Bila, Rostyslav Bilyy, Andriy Mokhir   +4 more
wiley   +1 more source

No evidence of molecular markers of piperaquine resistance in southeastern Nigeria. [PDF]

Malar J
Ikegbunam M, Tzirtziganis V, Rodi M, Anagu L, Pessanha de Carvalho L, Inoue J, Held J.   +6 more
europepmc   +1 more source

Antimalarial Activity of 77 Phospholipid Polar Head Analogs: Close Correlation Between Inhibition of Phospholipid Metabolism and In Vitro Plasmodium Falciparum Growth [PDF]

, 1998
Marie‐Laure Ancelin, Michèle Calas, Jacques Bompart, Gérard Cordina, Dominique Martin, Mohammed Ben Bari, Taı̈b Jei, Pierre Druilhe, Henri Vial   +8 more
openalex   +1 more source

A combination of new screening assays for prioritization of transmission-blocking antimalarials reveals distinct dynamics of marketed and experimental drugs.

Journal of Antimicrobial Chemotherapy, 2015
J. Bolscher, Karin M. J. Koolen, G. V. Gemert, M. Vegte-Bolmer, T. Bousema, D. Leroy, R. Sauerwein, K. Dechering   +7 more
semanticscholar   +1 more source

C1′‐Branched Acyclic Nucleoside Phosphonates as Inhibitors of Plasmodium Falciparum 6‐Oxopurine Phosphoribosyltransferase

ChemMedChem, Volume 20, Issue 19, October 6, 2025.
Novel C1'‐branched acyclic nucleoside phosphonates were synthesized. The compounds are inhibitors of Plasmodium falciparum and human 6‐oxopurine phosphoribosyltransferases with Ki values as low as 0.4 µM and 0.7 µM, respectively. A phosphonodiamidate prodrug exhibited IC50 = 4.3 µM against a drug‐sensitive strain of P.
Jan Frydrych, Dianne T. Keough, Haojun Xia, Lenka Poštová Slavětínská, Martin Dračínský, Michal Česnek, Jye Travis, Marina Chavchich, Michael Edstein, Dana Hocková, Luke W. Guddat, Zlatko Janeba   +11 more
wiley   +1 more source

Antimalarial compounds exhibit variant- and cell-type-specific activity against SARS-CoV-2 isolated in Panama. [PDF]

Front Pharmacol
Quijada M, Castillo-Bultron M, Díaz Y, Pitti Y, Franco D, De La Guardia C, Campos D, Cornejo E, Núñez M, Mendoza L, López-Vergès S, Magallon-Tejada AH, Obaldia N.   +12 more
europepmc   +1 more source

Comparison of the Curative Antimalarial Activities and Toxicities of Primaquine and Its d and l Isomers

, 1977

openalex   +1 more source

The Plasmodium falciparum Translationally Controlled Tumor Protein Homolog and Its Reaction with the Antimalarial Drug Artemisinin [PDF]

, 1998
Jamaree Bhisutthibhan, Xing-Qing Pan, Paul A. Hossler, Daniel J. Walker, Charles A. Yowell, Jane M. Carlton, John B. Dame, Steven R. Meshnick   +7 more
openalex   +1 more source

Solid lipid nanoparticles encapsulating a fluorescent marker (coumarin 6) and antimalarials – artemether and lumefantrine: evaluation of cellular uptake and antimalarial activity

, 2016
A. Attama, F. Kenechukwu, E. Onuigbo, P. Nnamani, N. Obitte, J. H. Finke, S. Pretor, C. Müller-Goymann   +7 more
semanticscholar   +1 more source

Translation of a Human‐Based Malaria‐on‐a‐Chip Phenotypic Disease Model for In Vivo Applications

Advanced Science, Volume 12, Issue 38, October 13, 2025.
Inoculation of the Malaria‐on‐a‐Chip model with human erythrocytes infected with Plasmodium falciparum can support the entire intraerythrocytic lifecycle for 7 days in vitro. Utilizing this human‐based, serum‐free model provides an alternative to animal testing by introducing a human‐based, preclinical alternative for antimalarial therapeutic delivery.
Michael J. Rupar, Hannah M. Hanson, Brianna L. Botlick, Narasimhan Sriram, Stephanie Rogers, Justin Zuniga, Zhanhe Liu, Steven J. Trimmer, Joseph M. Ciurca, Christopher J. Long, Christopher W. McAleer, Stephan Schmidt, Paola Favuzza, Philip Lowe, Nathalie Gobeau, James J. Hickman   +15 more
wiley   +1 more source