Results 241 to 250 of about 51,125 (324)

Chemical Protein Engineering: Backbone Cyclization Rescues Folding of a 183‐Residue Truncated Domain of Malaria Parasite Protein PfAMA1

Chemistry – A European Journal, Volume 31, Issue 28, May 19, 2025.
We report the first chemical synthesis of a 183‐residue functional truncated cyclic PfAMA1 domain I protein using multi‐segment native chemical ligation and head‐to‐tail cyclization to introduce conformational constraints, thereby facilitating protein folding and providing novel strategies for miniature protein engineering.
Jamsad Mannuthodikayil, Vishal Malik, Abhisek Kar, Sameer Singh, Kalyaneswar Mandal   +4 more
wiley   +1 more source

Efficacy and safety of guselkumab in patients with active lupus nephritis: results from a phase 2, randomized, placebo-controlled study. [PDF]

Rheumatology (Oxford)
Anders HJ, Chan TM, Sanchez-Guerrero J, Wofsy D, Bensley K, Kim L, Lo KH, Shu C, Shao J, Karyekar CS, Diamond B.   +10 more
europepmc   +1 more source

Amino‐Substituted 1,3‐Diazaazulenes: Synthesis, Structural Studies, Reactivity, and Photophysical Properties

Chemistry – A European Journal, Volume 31, Issue 27, May 14, 2025.
High regioselection in the synthesis of brominated and amino‐substituted 1,3‐diazaazulenes enables regiocontrolled access to a series of differently substituted 4‐, 6‐, and 8‐amino‐1,3‐diazaazulenes with soft‐tunable optical properties. The tetra‐aminosubstituted diazaazulenes are not entirely planar, as observed by crystallographic and computational ...
Teppo O. Leino, Anton Bannykh, Toni Eskelinen, Andrey Belyaev, Petri M. Pihko   +4 more
wiley   +1 more source

Continuous Flow Technology Enabling Photochemistry

Advanced Synthesis &Catalysis, Volume 367, Issue 9, May 6, 2025.
Abstract The merger of continuous flow technology and modern photochemistry has enabled countless applications showcasing new opportunities for chemical synthesis demonstrating improvements in selectivity, safety, sustainability and scalability. This focused review aims to highlight a selection of recently published case studies from academic and ...
Ruairi Crawford, Marcus Baumann
wiley   +1 more source

On the molecular mechanism of chloroquine's antimalarial action. [PDF]

, 1996
David J. Sullivan, Ilya Y. Gluzman, David G. Russell, Daniel E. Goldberg   +3 more
openalex   +1 more source

The private market for antimicrobials: an exploration of two selected mining and frontier areas of Guyana. [PDF]

Rev Panam Salud Publica
Cox H, Roeder F, Okell L, Niles-Robin R, James K, Valz O, Hauck K, Sicuri E.   +7 more
europepmc   +1 more source

Inhibition of the peroxidative degradation of haem as the basis of action of chloroquine and other quinoline antimalarials [PDF]

, 1999
P.M. Loria, Susanne K. Miller, Michael Foley, Leann Tilley   +3 more
openalex   +1 more source

Tambjamines as Fast-Acting Multistage Antimalarials. [PDF]

ACS Infect Dis
Kumar A, Li Y, Dodean RA, Roth A, Caridha D, Madejczyk MS, Jin X, Dennis WE, Lee PJ, Pybus BS, Martin M, Pannone K, Dinh HT, Blount C, Chetree R, DeLuca J, Evans M, Nadeau R, Vuong C, Leed S, Black C, Sousa J, Nolan C, Ceja FG, Rasmussen SA, Tumwebaze PK, Rosenthal PJ, Cooper RA, Rottmann M, Orjuela-Sanchez P, Meister S, Winzeler EA, Delves MJ, Matthews H, Baum J, Kirby RW, Burrows JN, Duffy J, Peyton DH, Reynolds KA, Kelly JX, Kancharla P.   +41 more
europepmc   +1 more source

Artemisinin and the antimalarial endoperoxides: from herbal remedy to targeted chemotherapy [PDF]

, 1996
Steven R. Meshnick, Terrie E. Taylor, Sumalee Kamchonwongpaisan   +2 more
openalex   +1 more source

Population-Based Prevalence of Antibiotic Residuals in Low, Moderate and High Malaria Endemicity Areas in Tanzania. [PDF]

Antibiotics (Basel)
Lotto T, Gallay J, Zuakulu M, Ternon B, Decosterd LA, Kulinkina AV, Genton B.   +6 more
europepmc   +1 more source