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Adebrelimab plus capecitabine versus capecitabine monotherapy for adjuvant treatment of high-risk resected cholangiocarcinoma (ACHIEVE): protocol for a phase II, multicentre, randomised controlled trial. [PDF]
BMJ Open GastroenterolCheng Y, Zhang Y, Li C, Li X.
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Synthesis and use of polyamine derivatives as internal mass spectrometry standards [PDF]
Dar, Sami Ullah
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The efficacy and toxicity of antineoplastic antimetabolites: Role of gut microbiota
Toxicology, 2021The incidence and mortality of cancer are rapidly growing all over the world. Nowadays, antineoplastic antimetabolites still play a key role in the chemotherapy of cancer. However, the interindividual variations in the efficacy and toxicity of antineoplastic antimetabolites are nonnegligible challenges to their clinical applications.
Xinyi Huang +8 more
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Nelarabine: A novel purine antimetabolite antineoplastic agent
Clinical Therapeutics, 2007Nelarabine was approved by the US Food and Drug Administration (FDA) in October 2005 for the treatment of T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LBL) that has not responded to or has relapsed after treatment with at least 2 chemotherapy regimens.This article reviews the pharmacology, mechanism of action, and ...
Larry W, Buie +2 more
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International Journal of Radiation Oncology*Biology*Physics, 1986
Defining specific biochemical targets of active antineoplastic agents could aid in discovering better anticancer therapy and more thoroughly understanding the biochemical basis of malignancy. Through a series of cellular and biochemical studies, we and others have identified the nuclear enzyme topoisomerase II as the target of several active agents ...
L A, Zwelling, L, Silberman, E, Estey
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Defining specific biochemical targets of active antineoplastic agents could aid in discovering better anticancer therapy and more thoroughly understanding the biochemical basis of malignancy. Through a series of cellular and biochemical studies, we and others have identified the nuclear enzyme topoisomerase II as the target of several active agents ...
L A, Zwelling, L, Silberman, E, Estey
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Glycolysis-dependent antimetabolites: Possible improvement in antineoplastic selectivity
Medical Hypotheses, 1979The increased rate of glycolysis in neoplastic cells may be used to design tentatively antimetabolites whose detoxification would be faster in normal cells. Pyruvo-substituted nucleotides are examined in this respect and their expected differential metabolism outlined.
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Stability of solutions of antineoplastic agents during preparation and storage for in vitro assays
Cancer Chemotherapy and Pharmacology, 1989The stability of solutions of the antitumour antimetabolites, vinca alkaloids, podophyllotoxins, interferons, steroids and platinum drugs as well as maytansine, asparaginase, amsacrine, flavone-8-acetic acid, mitoguazone, and N-phosphonoacetyl-L-aspartate (PALA) is reviewed.
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[5'-deoxy-5-fluoruridine, a new antineoplastic pyrimidine antimetabolite].
Schweizerische medizinische Wochenschrift, 19805'-deoxy-5-fluorouridine (5-DFUR) exerts a marked cytostatic activity, both intraperitoneally and orally, against experimental tumors. It has a strong antitumor effect on the Crocker sarcoma S 180, the Lewis lung carcinoma and a chemically induced squamous cell carcinoma of the skin. Its ratio of antitumor activity toxicity is more favourable than that
H R, Hartmann, W, Bollag
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Bollettino della Societa italiana di biologia sperimentale, 1976
G, Massa +3 more
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G, Massa +3 more
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