Incidence of drug-induced liver injury in medical inpatients [PDF]
, 2018 Objectives: Drug-induced liver injury (DILI) is a common concern. However, data on DILI epidemiology in inpatients are sparse. Methods: To investigate the incidence of DILI, we screened all patients in the pharmacoepidemiological inpatient database ...
Cavallaro, Marzia +6 more
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A Systematic Review of Iran’s Medicinal Plants With Anticancer Effects [PDF]
, 2015 Increase in cases of various cancers has encouraged the researchers to discover novel, more effective drugs from plant sources. This study is a review of medicinal plants in Iran with already investigated anticancer effects on various cell lines.
Asadi-Samani, Majid. +3 more
core +1 more source
Polymeric organoiron compounds with carcinostatic properties (branched hydrazone linkers) [PDF]
, 2011 The insufficient efficaciousness of most currently used anticancer drugs has prompted worldwide efforts to reduce toxic and resistance effects, improve overall bioavailability, and widen the therapeutic window. A particularly promising technology to this
Nkazi, Bavon Diakanua
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Cytotoxic Properties of Anthraquinones (Nordamnacanthal and Damnacanthal) from Roots of Morinda Elliptica [PDF]
, 2003 The study on the cytotoxic properties of nordamnacanthal and damnacanthal, the anthraquinones isolated from the roots of Morinda elliptica (family Rubiaceae) were carried out on several cancerous cell lines including CEM-SS (T-lymphoblastic leukaemia),
Saiful Yazan, Latifah
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Not only P-glycoprotein: amplification of the ABCB1-containing chromosome region 7q21 confers multidrug resistance upon cancer cells by coordinated overexpression of an assortment of resistance-related proteins [PDF]
, 2017 The development of drug resistance continues to be a dominant hindrance toward curative cancer treatment. Overexpression of a wide-spectrum of ATP-dependent efflux pumps, and in particular of ABCB1 (P-glycoprotein or MDR1) is a well-known resistance ...
Assaraf, Yehuda G. +4 more
core +1 more source
Perspectives and Prospects in the Chemotherapy of Gastrointestinal Cancer [PDF]
, 1967 5-Flourouracil (5-FU) is the best agent for the treatment of all gastrointestinal cancers but should be used with restraint, since severe toxicity does not guarantee increased response or survival time.
Regelson, William
core +1 more source
Effects of daunorubicin, mitomycinC, azathioprine and cyclosporinA on human retinal pigmented epithelial, corneal endothelial and conjunctival cell lines [PDF]
, 2018 Background: We wished to investigate the toxicity of four immunosuppressant and antimetabolic drugs, which are known to influence postoperative wound healing, on three different human ocular cell lines.
Garweg, Justus +2 more
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A genome scale overexpression screen to reveal drug activity in human cells [PDF]
, 2014 core +1 more source
Synergistic Effect of Trichostatin a and Thymoquinone in Inducing Anticancer Activity in Breast Cancer [PDF]
, 2015 The field of epigenetic has witnessed a recent breakthrough in our information and stands at the forefront of biomedical research. Epigenetic alterations may result in changes in chromatin structure leading to a deregulation of gene expression associated
Patel, Priti
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[Expression of Concern] 5‑Azacytidine inhibits the proliferation of bladder cancer cells via reversal of the aberrant hypermethylation of the hepaCAM gene. [PDF]
Oncol RepWang X +6 more
europepmc +1 more source