Results 41 to 50 of about 655,643 (249)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Antimicrobial resistance of nosocomial Acinetobacter spp. isolates in Russia: results of multicenter epidemiological study «MARATHON» 2013-2014 [PDF]

Клиническая микробиология и антимикробная химиотерапия, 2017
Acinetobacter baumannii and related species of the A. baumannii complex are the common and one of the most difficult-to-treat nosocomial pathogens. In this paper, we report the data on antimicrobial susceptibility of 568 isolates of Acinetobacter spp ...
Sukhorukova M.V., Edelstein M.V., Skleenova E.Yu., Ivanchik N.V., Shek E.A., Dekhnich A.V., Kozlov R.S., «MARATHON» Study Group   +7 more
doaj  

Determining the impact of professional body recommendations on the screening of acquired carbapenemase-producing Enterobacterales in England

Infection Prevention in Practice, 2023
Summary: Introduction: Acquired carbapenemase-producing Gram-negative bacteria are an increasing public health concern globally and have been mandatory to report in England since October 2020. However, in light of the COVID-19 (SARS-CoV-2) pandemic, the
Kirsty F. Bennet, Rebecca L. Guy, Sarah M. Gerver, Katie L. Hopkins, Richard Puleston, Colin S. Brown, Katherine L. Henderson   +6 more
doaj   +1 more source

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source

A validation study on a standardized assessment algorithm for antimicrobial prescribing appropriateness

Antimicrobial Stewardship & Healthcare Epidemiology
Background: Since 2013, the Australian Hospital National Antimicrobial Prescribing Survey (Hospital NAPS) has provided a standardized framework for hospitals to assess the quality of antimicrobial prescribing.
Caroline Chen, Josephine Wen, Courtney Ierano, Jenna Maleki, Tim Spelman, Rodney James, Karin Thursky, Lisa Hall   +7 more
doaj   +1 more source

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

FEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli, Enrico Landi, Francesco Maiurano, Irene Paris, Rosanna Papa, Marco Artini, Laura Selan, Stefano Borocci, Francesco Buonocore, Esther Imperlini   +9 more
wiley   +1 more source

Small molecule produced by Photorhabdus interferes with ubiquinone biosynthesis in Gram-negative bacteria

mBio
We report the identification of 3,6-dihydroxy-1,2-benzisoxazole (DHB) in a screen of Photorhabdus and Xenorhabdus, whose symbiotic relationship with eukaryotic nematodes favors secondary metabolites that meet several requirements matching those for ...
Rachel Bargabos, Akira Iinishi, Bryson Hawkins, Thomas Privalsky, Norman Pitt, Sangkeun Son, Rachel Corsetti, Michael F. Gates, Ryan D. Miller, Kim Lewis   +9 more
doaj   +1 more source

In vivo evolution of an emerging zoonotic bacterial pathogen in an immunocompromised human host

Nature Communications, 2021
Bordetella hinzii is an emerging pathogen with zoonotic risk to humans, known to be able to cause respiratory tract infection, bacteremia and endocarditis.
A. Launay, C.-J. Wu, A. Dulanto Chiang, J.-H. Youn, P. P. Khil, J. P. Dekker   +5 more
doaj   +1 more source

Acinetobacter Non-baumannii Species: Occurrence in Infections in Hospitalized Patients, Identification, and Antibiotic Resistance

Antibiotics, 2023
Background: Acinetobacter species other than A. baumannii are becoming increasingly more important as opportunistic pathogens for humans. The primary aim of this study was to assess the prevalence, species distribution, antimicrobial resistance patterns,
Eugene Sheck, Andrey Romanov, Valeria Shapovalova, Elvira Shaidullina, Alexey Martinovich, Natali Ivanchik, Anna Mikotina, Elena Skleenova, Vladimir Oloviannikov, Ilya Azizov, Vera Vityazeva, Alyona Lavrinenko, Roman Kozlov, Mikhail Edelstein   +13 more
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source