Results 31 to 40 of about 689,458 (266)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

AGREEMENT ANALYSIS BETWEEN AN ALGORITHM AND INFECTIOUS DISEASE SPECIALISTS IN ANTIBIOGRAM-GUIDED ANTIBIOTIC SELECTION

Brazilian Journal of Infectious Diseases
Introduction/Objective: Variability among specialists within the same specialty limits studies that use clinical judgment as a gold standard and can lead to inconsistent decisions.
Victor Hugo Ovani Marchetti, Mariana Lanna Magalhães Veríssimo, Juliana Veríssimo Lanna, Natanael Sutikno Adiwardana   +3 more
doaj   +1 more source

Risk factors and outcomes associated with persistent vancomycin resistant Enterococcal Bacteremia

BMC Infectious Diseases, 2022
Background Prior studies have identified that vancomycin resistant enterococcus (VRE) bacteremia that persists for four days or more is an independent predictor of mortality.
Emily Fox, David Ha, Mark Bounthavong, Lina Meng, Emily Mui, Marisa Holubar, Stanley Deresinski, William Alegria   +7 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

COMPARISON BETWEEN A DETERMINISTIC DIGITAL ALGORITHM AND LARGE LANGUAGE MODELS FOR DECISION-MAKING ON UROCULTURE-GUIDED ANTIBIOTIC THERAPY

Brazilian Journal of Infectious Diseases
Introduction: The increasing use of artificial intelligence (AI) in clinical decision-making requires rigorous validation, especially in critical scenarios such as antimicrobial prescribing guided by antibiogram.
Victor Hugo Ovani Marchetti, Mariana Lanna Magalhães Veríssimo, Juliana Veríssimo Lanna, Natanael Sutikno Adiwardana   +3 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

LARGE-SCALE ARTIFICIAL INTELLIGENCE OR MEDICAL RESIDENCY: WHO AGREES MORE WITH INFECTIOUS DISEASE SPECIALISTS IN ANTIBIOGRAM-GUIDED ANTIBIOTIC SELECTION?

Brazilian Journal of Infectious Diseases
Introduction: Optimizing antibiotic therapy is essential given the growing antimicrobial resistance. Variability in therapeutic decision-making among health professionals is a challenge, especially across different stages of training.
Victor Hugo Ovani Marchetti, Mariana Lanna Magalhães Veríssimo, Juliana Veríssimo Lanna, Natanael Sutikno Adiwardana   +3 more
doaj   +1 more source

Antimicrobial resistance of nosocomial Staphylococcus aureus isolates in Russia: results of multicenter epidemiological study «MARATHON» 2013-2014 [PDF]

Клиническая микробиология и антимикробная химиотерапия, 2017
The study included 418 of the 841 clinical isolates of S. aureus, which were regarded as nosocomial. These 418 clinical nosocomial S. aureus strains were isolated in 2013-2014 from patients hospitalized in 25 hospitals in 19 Russian cities.
Romanov A.V., Dekhnich A.V., Sukhorukova M.V., Skleenova E.Yu., Ivanchik N.V., Edelstein M.V., Kozlov R.S., «MARATHON» Study Group   +7 more
doaj  

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source