Results 231 to 240 of about 108,703 (323)

Conformational Snapshots of CydDC in a Native Lipid Bilayer Coupling Heme Transport to Antibiotic Resistance

Advanced Science, EarlyView.
Phylogenetic and biochemical analyses of the heme transporter CydDC reveal its functional conservation throughout bacterial evolution and demonstrate its unique asymmetric allosteric mechanism. Furthermore, impairment of CydDC function directly affects bacterial antibiotic resistance and likely compromises antibiotic efficacy through drug efflux.
Lili Yang, Changbin Zhang, Mengyuan Lyu, Yongbo Luo, Jierou Zhang, Yujiao Chen, Lintao Luo, Wen Qiao, Xiangyangpeng Li, Yu Zhou, Zhongling Wei, Yuling Xiao, Qian Niu, Juan Zhou, Guanglin He, Binwu Ying, Zhaoming Su, Hao Chen, Xiaodi Tang, Haohao Dong   +19 more
wiley   +1 more source

Furfuryl Alcohol‐Driven Proton Supply Enables Efficient Photocatalytic H2O2 Production Beyond Water‐Based Systems

Advanced Science, EarlyView.
A ZnIn2S4–carbon dot heterojunction enables photocatalytic H2O2 production coupled with furfuryl alcohol oxidation. In this redox system, furfuryl alcohol acts as both the electron donor and oxidation substrate, producing furoic acid with 100% selectivity and 98% conversion while supporting efficient H2O2 generation with a solar‐to‐chemical conversion (
Pengfei Bai, Ning Li, Quan Zhou, Bin Liu, Xiangqian Fan, Lei Liu, Jingkai Lin, Weijie Ren, Shengliang Hu, Huayang Zhang   +9 more
wiley   +1 more source

Comparison of Spectrum Coverage Score-based Antimicrobial Consumption in Acute Care Hospitals Over Eight Years: A Multicentric Study. [PDF]

Open Forum Infect Dis
Honda H, Murakami S, Kosugi T, Ito A, Hata T, Sasaki Y, Hamamoto Y, Wakugawa T, Shiroma M, Nakamura K, Shiohira H, Tokuda Y.   +11 more
europepmc   +1 more source

Targeting a Myeloid–Regulatory B Cell Network Reverses Immune Paralysis in Periprosthetic Joint Infections

Advanced Science, EarlyView.
Periprosthetic joint infection establishes a sophisticated immunosuppressive network between CXCR4+ PMN‐MDSCs and Bregs, inducing profound CD8+ T cell paralysis. Alendronate effectively disrupts this CXCR4+ PMN‐MDSC–Breg axis by targeting STAT3, thereby restoring local immune surveillance.
Jintao Wu, Shutao Zhang, Yumin Lin, Juyang Jiao, Zhiwei Fu, Qimin Hong, Ziyi Zhao, Xinhua Qu, Fei Su, Bing Yue   +9 more
wiley   +1 more source

Targeting Lipopolysaccharide Transport Induces Membrane Lipid Remodeling and Sensitizes Acinetobacter baumannii to Colistin Treatment

Advanced Science, EarlyView.
This study identifies C4 as a lead inhibitor of the Lpt system. Notably, C4 potentiates colistin activity by disrupting LPS transport and remodeling phospholipid homeostasis, revealing a functional interplay between the Lpt and Mla systems. These findings establish a mechanistic link between Lpt inhibition and membrane lipid remodeling, positioning Lpt–
Jianya Luo, Hetianzi Zhang, Jinju Cai, Shuang Zhou, Haijie Zhang, Zhiqiang Wang, Yuan Liu   +6 more
wiley   +1 more source

Ethiopian antimicrobial consumption trends in human health sector: A surveillance report 2020-2022. [PDF]

PLoS One
Eshete H, Tileku M, Aschenaki A, Shiferaw E, Mulugeta H, Teferi M, Shute T, Alemu A, Gerba H, Fentie AM.   +9 more
europepmc   +1 more source

Light‐Activated Ruthenium Nanoclusters Reprogram the Metabolic‐Quorum Sensing Axis for Precision Periodontitis Therapy

Advanced Science, EarlyView.
Under 660 nm visible light, Ru NCs efficiently photocatalyze nitrate‐to‐ammonium conversion and modulate oral nitrogen metabolism. They precisely perturb Veillonella parvula, block its key support to Porphyromonas gingivalis, and exert an “inhibiting without killing” antivirulence effect.
Jing Zhou, Xiaolin Sun, Chengyu Liu, Yujia Shi, Meiqi Li, Meng Bo, Jingjie Zhai, Chunyan Li, Zhennan Wu, Xue Bai, Lin Wang   +10 more
wiley   +1 more source

National Antimicrobial Consumption in Latin America and the Caribbean: Measurements and Results from 2019-2022. [PDF]

Antibiotics (Basel)
Marin GH, Giangreco L, Lichtenberger P, Dorati C, Mordujovich P, Rojas-Cortés R, Orjuela-Rodríguez T, Ramón-Pardo P, Castro JL, Marin D, Ramirez A, de Carvalho ALU, Boni S, Williams J, Aldunate-González MF, López-Peña M, Fung SMC, Marín-Piva H, Alfonso-Orta I, Singh S, Rodríguez-Mejía A, Molina AM, Buzarquis C, Mantilla-Ponte H, Matthew V, James GM, Nagassar RP.   +26 more
europepmc   +1 more source

Relation between Injectable Antimicrobial Consumption and Antimicrobial Susceptibility of Pseudomonas aeruginosa

Japanese Journal of Environmental Infections, 2012
NAKAI, Hajime, NAKAMURA, Kazunari, SEKINO, Katsuhiro, ITO, Koji, WATANABE, Takuji, TERUNUMA, Yasunori, KUDO, Kasumi   +6 more
openaire   +2 more sources