Results 11 to 20 of about 119,446 (259)
Ionizable Lipid Containing Nanocarriers for Antimicrobial Agent Delivery
Small ScienceAntimicrobial resistance (AMR) poses a global health crisis demanding innovative solutions. Traditional antibiotics, though pivotal over the past century in combating bacterial infections, face diminished efficacy against evolving bacterial defense ...
Haitao Yu +9 more
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Lipid tails modulate antimicrobial peptide membrane incorporation and activity [PDF]
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2021 AbstractAntimicrobial peptides (AMPs) are cationic, amphipathic peptides that interact directly with lipid bilayers. AMPs generally interact with anionic lipid head groups, but it is less clear how the lipid tail length and saturation modulates interactions with membranes.
Lawrence R. Walker, Michael T. Marty
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Lipidated Peptidomimetics with Improved Antimicrobial Activity [PDF]
ACS Medicinal Chemistry Letters, 2012 We report a series of lipidated α-AApeptides that mimic the structure and function of natural antimicrobial lipopeptides. Several short lipidated α-AApeptides show broad-spectrum activity against a range of clinically related Gram-positive and Gram-negative bacteria as well as fungus.
Hu, Yaogang +9 more
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Antimicrobial Activity of Host-Derived Lipids [PDF]
Antibiotics, 2020 Host-derived lipids are increasingly recognized as antimicrobial molecules that function in innate immune activities along with antimicrobial peptides. Sphingoid bases and fatty acids found on the skin, in saliva and other body fluids, and on all mucosal surfaces, including oral mucosa, exhibit antimicrobial activity against a variety of Gram positive ...
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Thematic Review Series: Skin Lipids. Antimicrobial lipids at the skin surface [PDF]
Journal of Lipid Research, 2008 The skin surface represents our interface with the external environment, and as such, is our first line of defense against microbial colonization and infection. Lipids at the skin surface are thought to underlie at least part of an antimicrobial barrier.
David R. Drake +3 more
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Lipid selectivity in novel antimicrobial peptides: Implication on antimicrobial and hemolytic activity [PDF]
Colloids and Surfaces B: Biointerfaces, 2017 Antimicrobial peptides (AMPs) are small cationic molecules that display antimicrobial activity against a wide range of bacteria, fungi and viruses. For an AMP to be considered as a therapeutic option, it must have not only potent antibacterial properties but also low hemolytic and cytotoxic activities [1].
Maturana, Patricia del Valle +7 more
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Interaction of Antimicrobial Lipopeptides with Bacterial Lipid Bilayers [PDF]
The Journal of Membrane Biology, 2019 The resistance of pathogens to traditional antibiotics is currently a global issue of enormous concern. As the discovery and development of new antibiotics become increasingly challenging, synthetic antimicrobial lipopeptides (AMLPs) are now receiving renewed attention as a new class of antimicrobial agents.
Ganesh Shahane +4 more
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Nanotechnology Formulations for Antibacterial Free Fatty Acids and Monoglycerides
Molecules, 2016 Free fatty acids and monoglycerides have long been known to possess broad-spectrum antibacterial activity that is based on lytic behavior against bacterial cell membranes. Considering the growing challenges of drug-resistant bacteria and the need for new
Joshua A. Jackman +3 more
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Amphipathic Antimicrobial Piscidin in Magnetically Aligned Lipid Bilayers [PDF]
Biophysical Journal, 2011 The amphipathic antimicrobial peptide piscidin 1 was studied in magnetically aligned phospholipid bilayers by oriented-sample solid-state NMR spectroscopy. (31)P NMR and double-resonance (1)H/(15)N NMR experiments performed between 25 °C and 61 °C enabled the lipid headgroups as well as the peptide amide sites to be monitored over a range of ...
De Angelis, Anna A. +5 more
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Defensive‐lipid droplets: Cellular organelles designed for antimicrobial immunity
Immunological Reviews, 2023 SummaryMicrobes have developed many strategies to subvert host organisms, which, in turn, evolved several innate immune responses. As major lipid storage organelles of eukaryotes, lipid droplets (LDs) are an attractive source of nutrients for invaders. Intracellular viruses, bacteria, and protozoan parasites induce and physically interact with LDs, and
Rémi Safi +5 more
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