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Tuning Activity of Antimicrobial Peptides by Lipidation
2018Antimicrobial peptides (AMPs) are amino acid-based bioactive molecules that specifically target microbes. As such, they are a potent class of antibiotics, especially against bacterial infections. Naturally occurring AMPs are usually too long to be considered for therapeutic applications.
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Immobilized Lipid Affinity Capture for Antimicrobial Peptides Screening
Biotechnology and Bioprocess Engineering, 2018A novel method for rapid screening of antimicrobial peptides (AMPs) was developed by using immobilized lipid affinity capture (ILAC) coupled with LC-MS. Phospholipid (PL) mixture containing phosphatidyl glycerol (PG): phosphatidyl ethanolamine (PE) (4:1), roughly mimic the PL composition of Gram-positive bacterial membrane, was covalently immobilized ...
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Regulation of phospholipid distribution in the lipid bilayer by flippases and scramblases
Nature Reviews Molecular Cell Biology, 2023Shigekatzu Nagata
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Amyloidogenicity and lipid interaction of antimicrobial anuran peptides
2019Uperin 3.x antimicrobial peptides, which can also form amyloid-like fibrils, are appropriate to study the effect of salt concentration and cationic to hydrophobic residue substitution on fibril- formation propensity of antimicrobial peptides.
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Lipid biomarkers: molecular tools for illuminating the history of microbial life
Nature Reviews Microbiology, 2021Roger Everett Summons +2 more
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Regulation of membrane protein structure and function by their lipid nano-environment
Nature Reviews Molecular Cell Biology, 2022Ilya Levental, Edward Lyman
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Peptide-lipid interactions and mechanisms of antimicrobial peptides.
Novartis Foundation symposium, 1999Hydrophobic matching, in which transmembrane proteins cause the surrounding lipid bilayer to adjust its hydrocarbon thickness to match the length of the hydrophobic surface of the protein, is a commonly accepted idea. To test this idea, gramicidin was embedded in dilauroyl phosphatidylcholine (DLPC) and dimyristoyl phosphatidylcholine (DMPC) bilayers ...
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Non-vesicular lipid transport by lipid-transfer proteins and beyond
Nature Reviews Molecular Cell Biology, 2010Sima Lev
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