Results 221 to 230 of about 126,632 (254)

Lipid-Based Liquid Crystals As Carriers for Antimicrobial Peptides: Phase Behavior and Antimicrobial Effect

Langmuir, 2016
The number of antibiotic-resistant bacteria is increasing worldwide, and the demand for novel antimicrobials is constantly growing. Antimicrobial peptides (AMPs) could be an important part of future treatment strategies of various bacterial infection diseases. However, AMPs have relatively low stability, because of proteolytic and chemical degradation.
Boge, Lucas, Bysell, Helena, Ringstad, Lovisa, Wennman, David, Umerska, Anita, Cassisa, Viviane, Eriksson, Jonny, Joly-Guillou, Marie-Laure, Edwards, Katarina, Andersson, Martin   +9 more
openaire   +3 more sources

Interactions of an antimicrobial peptide, tachyplesin I, with lipid membranes

Biochimica et Biophysica Acta (BBA) - Biomembranes, 1991
Tachyplesin I, isolated from the acid extracts of hemocytes of Tachypleus tridentatus, is a cyclic broad-spectrum antimicrobial peptide forming a rigid, antiparallel beta-sheet because of two intramolecular S-S linkages. The strong binding of the peptide to lipopolysaccharides cannot explain the susceptibilities of gram positive bacteria and fungi to ...
K, Matsuzaki, M, Fukui, N, Fujii, K, Miyajima   +3 more
openaire   +2 more sources

Interaction of hydrophobic and amphipathic antimicrobial peptides with lipid bicelles

Journal of Peptide Science, 2014
Bicelles are model membrane systems that can be macroscopically oriented in a magnetic field at physiological temperature. The macroscopic orientation of bicelles allows to detect, by means of magnetic resonance spectroscopies, small changes in the order of the bilayer caused by solutes interacting with the membrane.
BORTOLUS, MARCO, DALZINI, ANNALISA, TONIOLO, CLAUDIO, Kyung Soo Hahm, MANIERO, ANNA LISA   +4 more
openaire   +3 more sources

Modulation of Antimicrobial Peptide Potency in Stressed Lipid Bilayers

Physical Review Letters, 2019
It is shown that the tendency of an archetypal antimicrobial peptide to insert into and perforate a simple lipid bilayer is strongly modulated by tensile stress in the membrane. The results, obtained through molecular dynamics simulations, have been demonstrated with several lipid compositions and appear to be general, although quantitative details ...
Valeria, Losasso, Ya-Wen, Hsiao, Fausto, Martelli, Martyn D, Winn, Jason, Crain   +4 more
openaire   +2 more sources

Antimicrobial lipids: Natural and synthetic fatty acids and monoglycerides

Lipids, 1977
AbstractOver 40 natural or synthetic lipophilic compounds were screened for antimicrobial activity. Gram (+) bacteria and yeasts but not Gram (−) bacteria were affected by these agents. Epimino and selena fatty acids are more active than their corresponding straight chain unsubstituted fatty acids.
J. J. Kabara, R. Vrable, M. S. F. Lie Ken Jie   +2 more
openaire   +2 more sources

Incorporation of the antimicrobial protein seminalplasmin into lipid bilayer membranes

European Biophysics Journal, 1985
The interaction between seminalplasmin, an antimicrobial protein from bull semen, and lipid bilayers has been investigated. The fluorescence of the single tryptophan residue of the protein was measured. In the presence of phosphatidylcholine or phosphatidic acid bilayer vesicles the fluorescence maximum was shifted to shorter wavelengths, indicating ...
Galla, H., Warncke, M., Scheit, K.
openaire   +3 more sources

Lipids as antimicrobials

2023
Catarina Leal Seabra, Rita M. Pinto, Cláudia Nunes, Salette Reis   +3 more
openaire   +1 more source

Tuning Activity of Antimicrobial Peptides by Lipidation

2018
Antimicrobial peptides (AMPs) are amino acid-based bioactive molecules that specifically target microbes. As such, they are a potent class of antibiotics, especially against bacterial infections. Naturally occurring AMPs are usually too long to be considered for therapeutic applications.
openaire   +3 more sources

Solvent-Free Microfluidic Fabrication of Antimicrobial Lipid Nanoparticles

ACS Applied Bio Materials
Antimicrobial lipid nanoparticles composed of monoglycerides offer a promising strategy to inhibit membrane-enveloped viral and bacterial pathogens. However, previous efforts mainly focused on fabricating nanoparticles from long-chain monoglycerides, which lack intrinsic antimicrobial activity but contribute to nanoparticle stability and structural ...
Marta Ruano, Tun Naw Sut, Sue Woon Tan, Alexander B. Mullen, Donald Kelemen, Valerie A. Ferro, Joshua A. Jackman   +6 more
openaire   +2 more sources

Lyophilized Lipid Liquid Crystalline Nanoparticles as an Antimicrobial Delivery System

Antibiotics, 2023
Clive Prestidge, Timothy Barnes, Muhammed Awad   +2 more
exaly