Results 31 to 40 of about 119,446 (259)

Polymyxin Resistance and Heteroresistance Are Common in Clinical Isolates of Achromobacter Species and Correlate with Modifications of the Lipid A Moiety of Lipopolysaccharide

Microbiology Spectrum, 2023
The Achromobacter genus includes opportunistic pathogens that can cause chronic infections in immunocompromised patients, especially in people with cystic fibrosis (CF). Treatment of Achromobacter infections is complicated by antimicrobial resistance. In
Lewis MacDonald, Sean Keenan, Flaviana Di Lorenzo, Nana E. Adade, Dervla T. D. Kenna, Beverley C. Millar, John E. Moore, José Ramos Vivas, Antonio Molinaro, Miguel A. Valvano   +9 more
doaj   +1 more source

Antimicrobial peptide activity is anticorrelated with lipid a leaflet affinity.

PLoS ONE, 2020
The activity of antimicrobial peptides (AMPs) has significant bacterial species bias, the mechanisms of which are not fully understood. We employed single-molecule tracking to measure the affinity of three different AMPs to hybrid supported bilayers ...
Nathaniel Nelson, Belita Opene, Robert K Ernst, Daniel K Schwartz   +3 more
doaj   +1 more source

Lipidated α/α-AA heterogeneous peptides as antimicrobial agents [PDF]

European Journal of Medicinal Chemistry, 2018
With an increase of resistance in bacteria there is an urgent need for alternative treatment methods that could complement conventional antibiotics. In the past two decades, focus has been drawn to Host Defense Peptides (HDPs) as potential antibiotic agents. Herein we reported our studies on the development of lipidated α/α-AA heterogeneous peptides as
Singh, Sylvia, Nimmagadda, Alekhya, Su, Ma, Wang, Minghui, Teng, Peng, Cai, Jianfeng   +5 more
openaire   +3 more sources

Core Steps of Membrane-Bound Peptidoglycan Biosynthesis: Recent Advances, Insight and Opportunities

Antibiotics, 2015
We are entering an era where the efficacy of current antibiotics is declining, due to the development and widespread dispersion of antibiotic resistance mechanisms. These factors highlight the need for novel antimicrobial discovery.
Alvin C. K. Teo, David I. Roper
doaj   +1 more source

A new variant of the colistin resistance gene MCR-1 with co-resistance to β-lactam antibiotics reveals a potential novel antimicrobial peptide.

PLoS Biology, 2023
The emerging and global spread of a novel plasmid-mediated colistin resistance gene, mcr-1, threatens human health. Expression of the MCR-1 protein affects bacterial fitness and this cost correlates with lipid A perturbation. However, the exact molecular
Lujie Liang, Lan-Lan Zhong, Lin Wang, Dianrong Zhou, Yaxin Li, Jiachen Li, Yong Chen, Wanfei Liang, Wenjing Wei, Chenchen Zhang, Hui Zhao, Lingxuan Lyu, Nicole Stoesser, Yohei Doi, Fang Bai, Siyuan Feng, Guo-Bao Tian   +16 more
doaj   +1 more source

Short, Lipidated Dendrimeric γ-AApeptides as New Antimicrobial Peptidomimetics

International Journal of Molecular Sciences, 2023
Antibiotic resistance is one of the most significant issues encountered in global health. There is an urgent demand for the development of a new generation of antibiotic agents combating the emergence of drug resistance. In this article, we reported the design of lipidated dendrimeric γ-AApeptides as a new class of antimicrobial agents.
Yafeng Wang, Menglin Xue, Ruixuan Gao, Soumyadeep Chakraborty, Shaohui Wang, Xue Zhao, Meng Gu, Chuanhai Cao, Xingmin Sun, Jianfeng Cai   +9 more
openaire   +2 more sources

Quercetin Caused Redox Homeostasis Imbalance and Activated the Kynurenine Pathway

Biology, 2020
The search for new and better antimicrobial therapy is a continuous effort. Quercetin is a polyphenol with promising antimicrobial properties. However, the understanding of its antimicrobial mechanism is limited.
Oluyomi Stephen Adeyemi, Chinemerem Ebugosi, Oghenerobor Benjamin Akpor, Helal F. Hetta, Sarah Al-Rashed, David Adeiza Otohinoyi, Damilare Rotimi, Akinyomade Owolabi, Ikponmwosa Owen Evbuomwan, Gaber El-Saber Batiha   +9 more
doaj   +1 more source

Evidence for a novel mechanism of antimicrobial action of a cyclic R-,W-rich hexapeptide. [PDF]

PLoS ONE, 2015
The development of antimicrobial peptides as new class of antibiotic agents requires structural characterisation and understanding of their diverse mechanisms of action. As the cyclic hexapeptide cWFW (cyclo(RRRWFW)) does not exert its rapid cell killing
Kathi Scheinpflug, Oxana Krylova, Heike Nikolenko, Charley Thurm, Margitta Dathe   +4 more
doaj   +1 more source

Effect of Structure on the Interactions between Five Natural Antimicrobial Compounds and Phospholipids of Bacterial Cell Membrane on Model Monolayers

Molecules, 2014
Monolayers composed of bacterial phospholipids were used as model membranes to study interactions of the naturally occurring phenolic compounds 2,5-dihydroxybenzaldehyde and 2-hydroxy-5-methoxybenzaldehyde, and the plant essential oil compounds ...
Stella W. Nowotarska, Krzysztof J. Nowotarski, Mendel Friedman, Chen Situ   +3 more
doaj   +1 more source

The Vibrio cholerae VprA-VprB Two-Component System Controls Virulence through Endotoxin Modification

mBio, 2014
The bacterial cell surface is the first structure the host immune system targets to prevent infection. Cationic antimicrobial peptides of the innate immune system bind to the membrane of Gram-negative pathogens via conserved, surface-exposed ...
Carmen M. Herrera, Alexander A. Crofts, Jeremy C. Henderson, S. Cassandra Pingali, Bryan W. Davies, M. Stephen Trent   +5 more
doaj   +1 more source