Results 11 to 20 of about 126,632 (254)
Ionizable Lipid Containing Nanocarriers for Antimicrobial Agent Delivery
Small ScienceAntimicrobial resistance (AMR) poses a global health crisis demanding innovative solutions. Traditional antibiotics, though pivotal over the past century in combating bacterial infections, face diminished efficacy against evolving bacterial defense ...
Haitao Yu +9 more
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Nanomaterials, 2021 Antimicrobial resistance is one of the biggest threats to global health as current antibiotics are becoming useless against resistant infectious pathogens. Consequently, new antimicrobial strategies are urgently required.
Lide Arana +2 more
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Lipid-based nanoparticles as novel drug delivery systems for antimicrobial agents [PDF]
The Iranian Journal of Veterinary Science and Technology, 2018 Despite the development of novel drugs and technologies in combating the infectious diseases, they remain as a global health challenge. The use of conventional antimicrobial drugs are always associated with problems such as antimicrobial resistance ...
Ali Rassouli, Alwan Al-Qushawi
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Lipidated Peptidomimetics with Improved Antimicrobial Activity [PDF]
ACS Medicinal Chemistry Letters, 2012 We report a series of lipidated α-AApeptides that mimic the structure and function of natural antimicrobial lipopeptides. Several short lipidated α-AApeptides show broad-spectrum activity against a range of clinically related Gram-positive and Gram-negative bacteria as well as fungus.
Hu, Yaogang +9 more
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Innate Antimicrobial Defense of Skin and Oral Mucosa
Antibiotics, 2020 This special issue intends to review and update our understanding of the antimicrobial defense mechanisms of the skin and oral cavity. These two environments are quite different in terms of water, pH, and nutrient availability, but have some common ...
Philip W. Wertz, Sarah de Szalay
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Antimicrobial Activity of Host-Derived Lipids [PDF]
Antibiotics, 2020 Host-derived lipids are increasingly recognized as antimicrobial molecules that function in innate immune activities along with antimicrobial peptides. Sphingoid bases and fatty acids found on the skin, in saliva and other body fluids, and on all mucosal surfaces, including oral mucosa, exhibit antimicrobial activity against a variety of Gram positive ...
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Aggregate, 2023 Antimicrobial peptides (AMPs) are potentially powerful alternatives to conventional antibiotics in combating multidrug resistance, given their broad spectrum of activity.
Bruce Lin +14 more
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Nanotechnology Formulations for Antibacterial Free Fatty Acids and Monoglycerides
Molecules, 2016 Free fatty acids and monoglycerides have long been known to possess broad-spectrum antibacterial activity that is based on lytic behavior against bacterial cell membranes. Considering the growing challenges of drug-resistant bacteria and the need for new
Joshua A. Jackman +3 more
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Interaction of Antimicrobial Lipopeptides with Bacterial Lipid Bilayers [PDF]
The Journal of Membrane Biology, 2019 The resistance of pathogens to traditional antibiotics is currently a global issue of enormous concern. As the discovery and development of new antibiotics become increasingly challenging, synthetic antimicrobial lipopeptides (AMLPs) are now receiving renewed attention as a new class of antimicrobial agents.
Ganesh Shahane +4 more
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Scientific Reports, 2020 Rapid infection diagnosis is critical to improving patient treatment and outcome. Recent studies have shown microbial lipids to be sensitive and selective biomarkers for identifying bacterial and fungal species and antimicrobial resistance.
Matthew Sorensen +9 more
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