Results 111 to 120 of about 801,510 (301)

Subversion of Atypical Mucin Traps by a Spore‐Coat Effector Blocks Cellular Immunity in Drosophila

Advanced Science, EarlyView.
While the entomopathogenic fungus Metarhizium robertsii can evade insect humoral immunity, its subversion of cellular defenses is still elusive. We identify Eac1 as a spore‐coat protein essential for infecting drosophilids by targeting atypical mucins (Sgf1 and Sgf2), which can entrap spores in a gel matrix and thereby facilitate hemocyte encapsulation.
Shiqin Li, Haimin Chen, Gangqi Fang, Dongxiang Wei, Hongyun Wu, Chen Chen, Song Hong, Chengshu Wang   +7 more
wiley   +1 more source

Computational Prediction and Structural Analysis of α-Hairpinins, a Ubiquitous Family of Antimicrobial Peptides, Using the Cysmotif Searcher Pipeline

Background: α-Hairpinins are a family of antimicrobial peptides, promising antimicrobial agents, which includes only 12 currently revealed members with proven activity, although their real number is supposed to be much higher.
Eugene A. Rogozhin, Anna A. Slavokhotova, Andrey A. Shelenkov   +2 more
core   +1 more source

Synergies with and Resistance to Membrane-Active Peptides

, 2020
Membrane-active peptides (MAPs) have long been thought of as the key to defeating antimicrobial-resistant microorganisms. Such peptides, however, may not be sufficient alone. In this review, we seek to highlight some of the common pathways for resistance,
Adam Kmeck, Robert J. Tancer, Gregory R. Wiedman, Cristina R. Ventura   +3 more
core   +1 more source

The Putative Role of Human Peritoneal Adipocytes in the Fight against Bacteria: Synthesis of the Antimicrobial Active Peptide DEFA1-3 [PDF]

, 2010
Background: Spontaneous peritonitis is a rather rare event, even in peritoneal dialysis (PD). As defensins are natural antimicrobial peptides, we hypothesized that adipocytes as the major constituents of the omentum could play an important role in ...
Paslakis, Georgios, Schmid, Holger, Schloendorff, Detlef, Keuneke, Christian, Schroppel, Bernd, Groene, Hermann-Josef   +5 more
core   +1 more source

Antimicrobial Peptides in Marine Animals and Their Application in Food Preservation

Shipin gongye ke-ji
Microbial contamination is considered an important contributor to both food spoilage and food safety issues, and the development of new natural antimicrobial agents with broad-spectrum and highly efficient bacterial inhibition has become a hot research ...
Ju CHEN, Wanting ZHU, Xingyuan HU, Deming GONG, Xiang LI, Yidi CAI, Dandan REN, Yunhai HE, Long WU, Qiukuan WANG, Hui ZHOU   +10 more
doaj   +1 more source

High‐Density E. Coli Cultivation Arrays for Combinatorial Drug Testing With Subsequent Lipid Profiling by MALDI‐MS

Advanced Science, EarlyView.
High‐throughput antibiotic cross‐gradient assays on microdroplet arrays. A multichannel printhead together with five pressure regulators forms droplet arrays of up to 20 832 droplets within 25 minutes. Each droplet contains unique concentrations of antibiotics, allowing to moniture a vast spectrum of bacterial repsonses over night. The bacterial growth
M. Breitfeld, C. L. Dietsche, F‐L. Born, I. Onipko, L. Blaase, P. S. Dittrich   +5 more
wiley   +1 more source

Origami of KR-12 Designed Antimicrobial Peptides and Their Potential Applications

This review describes the discovery, structure, activity, engineered constructs, and applications of KR-12, the smallest antibacterial peptide of human cathelicidin LL-37, the production of which can be induced under sunlight or by vitamin D.
Guangshun Wang, Jingwei Xie, Abraham Fikru Mechesso, D. Zarena, Jinghui Luo, Jayaram Lakshmaiah Narayana, Imran Ibni Gani Rather   +6 more
core   +1 more source

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

Antimicrobial Property and Mode of Action of the Skin Peptides of the Sado Wrinkled Frog, Glandirana susurra, against Animal and Plant Pathogens

, 2020
The Sado wrinkled frog Glandirana susurra has recently been classified as a new frog species endemic to Sado Island, Japan. In this study, we cloned 12 cDNAs encoding the biosynthetic precursors for brevinin-2SSa–2SSd, esculentin-2SSa, ranatuerin ...
Sakae Kikuyama, Tetsuya Kobayashi, Shawichi Iwamuro, Kaito Saito, Yuriko Inamura, Manami Suzuki, Itaru Hasunuma, Daisuke Ogawa   +7 more
core   +1 more source

Prediction of enzyme action for extraction of antimicrobial substances from Sus scrofa and Bos taurus

Пищевые системы
The study of antimicrobial compounds of animal origin, particularly antimicrobial peptides (AMPs), is a current research topic. However, extracting endogenous AMPs is a challenging process and requires the application of targeted enzymatic processing ...
E. K. Polishchuk, E. A. Kotenkova
doaj   +1 more source