Results 111 to 120 of about 151,205 (306)

Diversity of Pharmaceuticals Enhances Antibiotic Resistance in the Invertebrate Gut via Biofilm‐Mediated Mechanisms

Advanced Science, EarlyView.
Pharmaceutical diversity acts as an independent driver of antibiotic resistance in soil invertebrates. While bulk soil remains unaffected, the collembolan gut microbiome exhibits significant resistance gene enrichment under complex chemical exposure and diurnal warming.
Yi‐Fei Wang, Ya‐Ning Wang, Da Lin, Jia‐Yang Xu, Feng‐Yuan Qi, Hui‐Ling Cui, Hui‐Jie Lu, Min Qiao, Edward Topp, Dong Zhu, Matthias C. Rillig, Yong‐Guan Zhu   +11 more
wiley   +1 more source

Synergies with and Resistance to Membrane-Active Peptides

, 2020
Membrane-active peptides (MAPs) have long been thought of as the key to defeating antimicrobial-resistant microorganisms. Such peptides, however, may not be sufficient alone. In this review, we seek to highlight some of the common pathways for resistance,
Adam Kmeck, Robert J. Tancer, Gregory R. Wiedman, Cristina R. Ventura   +3 more
core   +1 more source

G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis

Advanced Science, EarlyView.
Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang, Cancan Yao, Yan Chen, Ke Cai, Zhouping Lu, Boxuan Wu, Kun Yu, Yan Shi, Jianyuan Zhao, Xiangyu Zhou   +9 more
wiley   +1 more source

Cell-Penetrating Antimicrobial Peptides with Anti-Infective Activity against Intracellular Pathogens

, 2022
Cell-penetrating peptides (CPPs) are natural or engineered peptide sequences with the intrinsic ability to internalize into a diversity of cell types and simultaneously transport hydrophilic molecules and nanomaterials, of which the cellular uptake is ...
Gabriela Silva Cruz, Cruz, Gabriela Silva, de Brito, Erika Helena Salles, Erika Helena Salles de Brito, Ariane Teixeira dos Santos, Rádis-Baptista, Gandhi, Gandhi Rádis-Baptista, dos Santos, Ariane Teixeira   +7 more
core   +1 more source

Antimicrobial Peptides: Properties and Applicability

Biological Chemistry, 2001
All organisms need protection against microorganisms, e. g. bacteria, viruses and fungi. For many years, attention has been focused on adaptive immunity as the main antimicrobial defense system. However, the adaptive immune system, with its network of humoral and cellular responses is only found in higher animals, while innate immunity is encountered ...
van 't Hof, W., Veerman, E.C.I., Helmerhorst, E.J., van Nieuw Amerongen, A.   +3 more
openaire   +4 more sources

Icariin Enhances the Enzymatic Activity of N‐acetylgalactosaminidase to Augment Akkermansia Abundance in Gut Microbiota for Improved PD‐1 Blockade Efficacy in Tumor Suppression

Advanced Science, EarlyView.
Icariin promoted the growth of Akk by enhancing the activity of N‐acetylgalactosaminidase (Amuc_0920), which enhanced mucin utilization and provided a favorable nutrient environment for bacterial growth. This icariin‐mediated enrichment of Akk further reshaped the tumor microenvironment and promoted CD8+ T cell infiltration, ultimately synergizing with
Shuangying Qiao, Liu Yang, Haibang Hao, Qiuxia Ding, Feng Ding, Zheng Chen, Jinfang Zhang, Yun He, Meng Li, Jun Xu, Chao Wang, Aiping Lu, Fangfei Li   +12 more
wiley   +1 more source

Antimicrobial Peptides in Marine Animals and Their Application in Food Preservation

Shipin gongye ke-ji
Microbial contamination is considered an important contributor to both food spoilage and food safety issues, and the development of new natural antimicrobial agents with broad-spectrum and highly efficient bacterial inhibition has become a hot research ...
Ju CHEN, Wanting ZHU, Xingyuan HU, Deming GONG, Xiang LI, Yidi CAI, Dandan REN, Yunhai HE, Long WU, Qiukuan WANG, Hui ZHOU   +10 more
doaj   +1 more source

A Keratinocyte‐Mast Cell NF‐κB2/CXCL2/IL‐6 Amplification Loop Enhances Cutaneous Antifungal Defense Against C. albicans

Advanced Science, EarlyView.
ABSTRACT Mast cells (MCs), key innate immune sentinels at the host–environment interface, serve as primary responders to invading pathogens. However, their specific contribution to host defense against cutaneous Candida albicans (C. albicans) infection and their synergy with other immune and non‐immune cells remain poorly understood. Here, we show that
Yan Yuan, Manyun Mao, Jiaan Zhang, Zhimin Duan, JiaNing Wang, Yujie Chen, Sihan Chen, Chuting Liang, Xvyue Zhou, Songmei Geng, Min Li, Xu Chen, Ni Lian   +12 more
wiley   +1 more source

The Assessment of Vitamin D, Antimicrobial Peptides and Procalcitonin in Bronchiectasis

, 2014
My research investigated the distribution of antimicrobial peptides (cathelicidin and β-defensin 2), vitamin D and the inflammatory marker procalcitonin, between systemic and localised respiratory levels in stable bronchiectasis patients.
Gartner, Sarah Nicole
core  

Origami of KR-12 Designed Antimicrobial Peptides and Their Potential Applications

This review describes the discovery, structure, activity, engineered constructs, and applications of KR-12, the smallest antibacterial peptide of human cathelicidin LL-37, the production of which can be induced under sunlight or by vitamin D.
Guangshun Wang, Jingwei Xie, Abraham Fikru Mechesso, D. Zarena, Jinghui Luo, Jayaram Lakshmaiah Narayana, Imran Ibni Gani Rather   +6 more
core   +1 more source