Results 131 to 140 of about 801,510 (301)

Chimeric IL‐6/4R‐LL37 Engineered Macrophages Achieve Synchronized Inflammation Control and Antimicrobial Defence in Sepsis

Advanced Science, EarlyView.
Engineered macrophages programmed in situ by LNP‐delivered IL‐6/4 fusion and LL37 mRNAs simultaneously dampen cytokine storm, promote M2‐like repair, and enhance direct bacterial killing in sepsis. This combinatorial strategy restores T cell and macrophage function, lowers organ bacterial burden, and improves survival, highlighting a precision, host ...
Tianyang Jie, Zheyu Zhang, Hao Zhang, Linke Bian, Penglong Zheng, Sijia Zhou, Minqi Wang, Mingyu Qu, Yufei Wang, Xinhua Qu, Bing Yue   +10 more
wiley   +1 more source

F‐Type Pyocin Versus Phage λ Tail: Conserved Hub, Divergent Fibers

Advanced Science, EarlyView.
Near‐atomic cryo‐EM structures of a Gram‐negative F‐type pyocin reveal a conserved tail tip architecture shared with bacteriophage λ together with a previously unrecognized side‐fiber attachment mode. These findings provide new insight into tailocin assembly and host recognition and establish a structural framework for engineering precision ...
Zhiwei Gu, Yufan Xie, Lanxin Wang, Luyan Ma, Xiaofei Ge, Jiawei Wang   +5 more
wiley   +1 more source

A Multidimensional Engineering Strategy Reprograms Microglia via Targeted and Sustained‐Release Extracellular Vesicles for Spinal Cord Injury Repair

Advanced Science, EarlyView.
A multifunctional EV‐based nanoplatform (Ang‐TEVs@Gel) was engineered via preconditioning, surface targeting, and ROS‐responsive hydrogel encapsulation to reprogram microglia. This system restored autophagy via miR‐664a‐3p/PIK3CA axis, cleared myelin debris, resolved neuroinflammation, and promoted axon remyelination, ultimately achieving robust motor ...
Wu Xiong, Minhao Liu, Mingming Zheng, Jizhou Jia, Ziyan Zhu, Guang Kong, Jie Liu, Juan Wang, Wenbo Li, Qingyuan Wang, Qian Zhu, Peiran Chan, Tao Qin, Jiayang Wu, Yongjie Zhang, Chunming Tang, Cong Li, Jin Fan   +17 more
wiley   +1 more source

Antimicrobial peptides in Echinoderms

Invertebrate Survival Journal, 2010
Antimicrobial peptides (AMPs) are important immune effector molecules for invertebrates, including echinoderms, which lack a vertebrate-type adaptive immune system. Here we summarize the knowledge of such peptides in echinoderms. Strongylocins are a novel family of cysteine-rich AMPs, recently identified in the sea urchins, Strongylocentrotus ...
Li, Chun, Haug, Tor, Stensvåg, Klara
openaire   +3 more sources

Machine Learning-Driven Discovery and Evaluation of Antimicrobial Peptides from Crassostrea gigas Mucus Proteome

Marine Drugs
Marine antimicrobial peptides (AMPs) represent a promising source for combating infections, especially against antibiotic-resistant pathogens and traditionally challenging infections.
Jingchen Song, Kelin Liu, Xiaoyang Jin, Ke Huang, Shiwei Fu, Wenjie Yi, Yijie Cai, Ziniu Yu, Fan Mao, Yang Zhang   +9 more
doaj   +1 more source

Alternating Shear Force of Respiration Regulates Cell Interactions of Fibroblasts and Macrophages to Promote Soft Tissue Integration of Chest Wall Polyetheretherketone Implants

Advanced Science, EarlyView.
Given that PEEK chest wall implants induce shear force at the soft tissue‐implant interface due to respiratory motion in the early in vivo post‐implantation stage. We confirmed that this mechanical stimulus triggers the PIEZO1/ITGB1/YAP1 signalling axis in L929 and the STAT6/p‐STAT6 pathway in RAW264.7, which in turn mediates adhesion and migration of ...
Rou Huang, Yangfan Huo, Jin Liu, Sida Liu, Minghai Ma, Hao Guo, Yuanquan Zhang, Xing Li, Xiao Liang, Jiawei Xiu, Ying Sun, Lijun Huang, Xiaolong Yan, Weiwei Wu, Lei Wang   +14 more
wiley   +1 more source

Covalently Linked Peptides and Membrane Potential Enable CyaA Segment Translocation

Advanced Science, EarlyView.
Using a newly developed Droplet Interface Bilayer‐Pipette assay, the authors show that two segments of the CyaA toxin cross membranes by distinct mechanisms. One segment translocates spontaneously, whereas the translocation of the other depends on membrane potential.
Gaia Scilironi, Nicolas Carvalho, Jacinthe Frangieh, Corentin Léger, Dorothée Raoux‐Barbot, J. Iñaki Guijarro, Daniel Ladant, Sophie Cribier, Nicolas Rodriguez, Alexandre Chenal   +9 more
wiley   +1 more source

Development of New Antimicrobial Peptides by Directional Selection

Background/Objectives: The global rise in antibiotic resistance necessitates the development of novel antimicrobial agents. Antimicrobial peptides (AMPs), key components of innate immunity, are promising candidates.
Bobrovsky, Pavel, Ekaterina Bessonova, Bessonova, Ekaterina, Brovina, Ksenia, Lazarev, Vassili, Ekaterina Grafskaia, Pavel Bobrovsky, Sabina Alieva, Vassili Lazarev, Daria Kharlampieva, Ksenia Brovina, Kharlampieva, Daria, Alieva, Sabina, Grafskaia, Ekaterina, Oksana Selezneva, Maria Serebrennikova, Valentin Manuvera, Manuvera, Valentin, Serebrennikova, Maria, Selezneva, Oksana   +19 more
core   +1 more source

Dual‐Targeting Biomimetic Nanozymes Loaded Microneedle Patch Promotes Scarless Wound Healing Through Anti‐Inflammatory and Anti‐Fibrotic Effects

Advanced Science, EarlyView.
This study developed a dual‐targeting biomimetic nanozyme hybrid system (Cu‐CeO2@ABs‐FTP) and integrated it with HAMA hydrogel to fabricate a microneedle patch (CAF@MN). The patch promotes fibroblast‐mediated wound repair, targets macrophages to induce M2 polarization, and targets myofibroblasts to exert anti‐fibrotic effects, thereby enabling rapid ...
Hongyi Zhang, Jinwei Li, Shan Hua, Shengming Wu, Chenlong He, Yuan Zhu, Ming Yin, Han Zhou, Huawei Liu, Chika Hasegawa, Jun Lyu, Keyue Xiao, Hua Jiang, Yilong Wang, Yuxin Qian   +14 more
wiley   +1 more source

Antibacterial and antiviral properties of Chenopodin-derived synthetic peptides [PDF]

Antimicrobial peptides have been developed based on plant-derived molecular scaffolds for the treatment of infectious diseases. Chenopodin is an abundant seed storage protein in quinoa, an An-dean plant with high nutritional and therapeutic properties ...
Pereira, Marília Gabriella A. G., Proaño-Bolaños, Carolina, Marcia L. Feijoo-Coronel, F. da Silva, José Maurício S., Diego Fernandes Lívio, José R. Almeida, Peña-Varas, Carlos, Carlos Peña-Varas, Fernandes Lívio, Diego, Lívio, Diego Fernandes, Marina Q. R. B. Rodrigues, Mendes, Bruno, de Oliveira, Leonardo Camilo, Mauro M. Teixeira, Bruno Mendes, Marília Gabriella A. G. Pereira, Monteros-Silva, Nina Q. Espinosa de los, Ketan Patel, Da Silva, José Maurício S. F., de Almeida, José R., Ramírez, David, Rodrigues, Marina Q. R. B., Patel, Ketan, José Antônio da Silva, Leonardo Camilo de Oliveira, Da Silva, José Antônio, Granjeiro, Paulo Afonso, Proaño Bolaños, Carolina, Nina Q. E. de los Monteros-Silva, Paulo Afonso Granjeiro, José Maurício S. F. da Silva, Feijoo-Coronel, Marcia L., Oliveira, Leonardo Camilo De, Almeida, José R., Espinosa de los Monteros Silva, Nina, Carolina Proaño-Bolaños, Vaiyapuri, Sakthi, G. Pereira, Marília Gabriella A., Vaiyapuri, Sakthivel, David Ramírez, Sakthivel Vaiyapuri, Teixeira, Mauro M., B. Rodrigues, Marina Q. R.   +42 more
core   +1 more source