Results 131 to 140 of about 126,899 (260)

Structural and Functional Siderophore Remodeling by Enzymatic Delipidation

Angewandte Chemie, EarlyView.
A surprising functional switch in bacterial siderophores was discovered through genome mining and the analysis of environmental and pathogenic Pandoraea species. Pandorachelin B, a lipocyclopeptide that promotes swarming motility, is cleaved by a specialized acylase, yielding a ring‐contracted, homodetic cyclopeptide, pandorachelin A, which exhibits ...
Elena Herzog, Keishi Ishida, Evelyn M. Molloy, Ron Hermenau, Kirstin Scherlach, Christian Hertweck   +5 more
wiley   +2 more sources

Antimicrobial Peptides in Fish: Mechanisms of Action and Applications in Aquaculture. [PDF]

Biology (Basel)
Zhou F, Zhou L, Wang P, Elisio M, Salaah S, Karimov B, Cao Q.   +6 more
europepmc   +1 more source

Human Leukocyte Elastase Triggered Nanoparticles for Targeted Antimicrobial Delivery and Oral Microbial Modulation

Advanced NanoBiomed Research, EarlyView.
This study explores enzyme‐responsive nanoparticles for targeted antimicrobial release in inflamed oral environments. Nanoparticles formed by complexing peptides and chlorhexidine respond to human leukocyte elastase and release chlorhexidine selectively. P7 (ECAAPVCE)‐based formulations show optimal properties and stability, with antimicrobial activity
Mohammed A. Hadis, Ignacio Insua, Farah N. S. Raja, Álvaro Vila, William M. Palin, Michael R. Milward, Paul R. Cooper, Sarah A. Kuehne, Owen Addison, Paco Fernandez‐Trillo   +9 more
wiley   +1 more source

Deep Learning Enables Identification of Antimicrobial Peptides Through Mechanochromic Fingerprints

Angewandte Chemie, EarlyView.
We demonstrate a new platform for antimicrobial peptide identification by combining polydiacetylene, hyperspectral imaging, and deep learning. The trained model classifies distinct spectral fingerprints into 14 peptide classes with 96.79% accuracy, revealing previously hidden molecular information beyond conventional colorimetric sensing.
Jiali Chen, Che‐Lun Chin, Qingzhen Zhu, Ling Chao, Kaori Sugihara   +4 more
wiley   +2 more sources

Flipping antimicrobial peptides in the exit tunnel of the bacterial ribosome. [PDF]

Nat Commun
Huang W, Berger MJ, Safdari HA, Klepacki D, Paternoga H, Baliga C, Wilson DN, Vázquez-Laslop N, Mankin AS.   +8 more
europepmc   +1 more source

Rewriting Tumor Immunity With Bacterial Membrane Vesicles: A Versatile and Potent Therapeutic Strategy

Advanced NanoBiomed Research, EarlyView.
Bacterial membrane vesicles (BMVs) emerge as promising platforms for cancer immunotherapy owing to their intrinsic adjuvant properties and tunable cargo delivery capabilities. Their ability to modulate the tumor microenvironment, enhance antitumor immune responses, and support personalized therapeutic strategies highlights their growing potential as ...
Md Sifat Rahi, Md Mijanur Rahman, Asma Talukder, Urooj Yousaf Virk, Jennifer C. Wilson, Nigel McMillan, Ming Q. Wei   +6 more
wiley   +1 more source

Azole γ‐Peptides Helix Switching via Heterocycle Substitutions

Angewandte Chemie, EarlyView.
Heterocycle substitution in azole‐based γ‐amino acids enables control over the helical shape of heterocyclic γ‐peptides. S↔N permutation in thiazole residues switches a canonical 9‐helix into a flexible helix exhibiting discontinuous hydrogen bonding.
Samantha Chaise, Claude Didierjean, Audrey Gacogne, Maxime Fillaudeau, Young Kee Kang, Aurélien Lebrun, Jean‐Louis Bantignies, Dominique Housset, Muriel Amblard, Ludovic T. Maillard, Baptiste Legrand   +10 more
wiley   +2 more sources

Modified Titanium Dental Implants: The Current Progress of Soft‐Tissue Integration Methods

Advanced NanoBiomed Research, EarlyView.
Dental implants are an established solution for tooth loss, yet achieving soft tissue integration (STI) around the transmucosal region remains a challenge. The natural tooth–gingiva interface is poorly replicated on titanium implants. This review explores surface modification strategies, ranging from surface chemistry and topography to biological ...
Daniel De Maria, Amy Gelmi, Peter C. Sherrell, Stefan Di Medio, Nhiem Tran, Kate Fox   +5 more
wiley   +1 more source

Antimicrobial Peptides and Systemic Inflammation: A Network Analysis. [PDF]

Immun Inflamm Dis
Pinheiro da Silva F, Soriano FG, Hajjar LA.   +2 more
europepmc   +1 more source

Injectable Bone Cements: A Generational Framework for Bioactivity, Porosity, and Mechanobiological Design at the Nanoscale

Advanced NanoBiomed Research, EarlyView.
Key demographic, biological, and material considerations that drive the need for advanced injectable bone cement technologies. Injectable bone cements (IBCs) are widely used in orthopaedic and craniofacial applications due to their minimally invasive delivery and ability to provide early mechanical stabilisation.
Frank Fei, Yogambha Ramaswamy, Young Jung No   +2 more
wiley   +1 more source