Results 71 to 80 of about 151,205 (306)

Screening of antimicrobial peptides from plants and their application in food

Shipin yu jixie
In recent years, with the emergence of resistance to traditional antibiotics and the growing interest in the development of natural antimicrobials, natural antimicrobial peptides have received extensive attention.
LIU Min, HUANG Xiangyu, WU Hao, WEN Li, CHENG Yunhui, CHEN Maolong   +5 more
doaj   +1 more source

Inhibitory activities of the synthetic antimicrobial peptides against cotton Verticillium dahliae

浙江大学学报. 农业与生命科学版, 2013
Verticillium wilt, caused by Verticillium dahliae (VD), is the most disastrous pathogen in cotton fungal diseases, which causes huge monetary losses by inducing vascular wilt and exists widely in China cotton planting area.
ZHAO Yijing, NI Mi, Noreen Bibi, WANG Xuede   +3 more
doaj   +1 more source

Optimization of the antimicrobial peptide Bac7 by deep mutational scanning

BMC Biology, 2022
Background Intracellularly active antimicrobial peptides are promising candidates for the development of antibiotics for human applications. However, drug development using peptides is challenging as, owing to their large size, an enormous sequence space
Philipp Koch, Steven Schmitt, Alexander Heynisch, Anja Gumpinger, Irene Wüthrich, Marina Gysin, Dimitri Shcherbakov, Sven N. Hobbie, Sven Panke, Martin Held   +9 more
doaj   +1 more source

Hydrocarbon Stapled Antimicrobial Peptides [PDF]

The Protein Journal, 2018
Abstract Antimicrobial peptides are promising candidates for anti-infective pharmaceuticals. Unfortunately, because of their low proteolytic and chemical stability, their usage is generally narrowed down to topical formulations. Until now, numerous approaches to increase peptide stability have been proposed.
Dorian Migoń, Damian Neubauer, Wojciech Kamysz   +2 more
openaire   +2 more sources

Microengineered Gradient Hydrogels for Mechanobiology

Advanced Healthcare Materials, EarlyView.
Gradient hydrogels are used to mimic the mechanical heterogeneity in native tissues, offering powerful in vitro platforms to study cell‐material interactions in diverse pathophysiological contexts. Here, we present a comprehensive review of the design and experimental considerations for stiffness gradient hydrogels, discussing exemplary achievements ...
Shin Wei Chong, Deepu Ashok, Anna Waterhouse, Marcela M. M. Bilek, Daniele Vigolo   +4 more
wiley   +1 more source

Discovering highly potent antimicrobial peptides with deep generative model HydrAMP

Nature Communications, 2023
Antimicrobial peptides emerge as compounds that can alleviate the global health hazard of antimicrobial resistance, prompting a need for novel computational approaches to peptide generation. Here, we propose HydrAMP, a conditional variational autoencoder
Paulina Szymczak, Marcin Możejko, Tomasz Grzegorzek, Radosław Jurczak, Marta Bauer, Damian Neubauer, Karol Sikora, Michał Michalski, Jacek Sroka, Piotr Setny, Wojciech Kamysz, Ewa Szczurek   +11 more
doaj   +1 more source

Epidermal Patch Technologies for Integrated Healthcare and Infection Management

Advanced Healthcare Materials, EarlyView.
Epidermal patches have evolved from simple wound coverings into multifunctional, skin‐conformable platforms integrating drug delivery, biosensing, and therapeutic functionalities. This review highlights their material innovations, fabrication strategies, and intelligent designs, including hydrogels, microneedles, and flexible electronics, while ...
Yuqi Wang, Atakan Tevlek, Pawel L. Urban, Boaz Mizrahi, Onome Ejeromedoghene, Roshan Deen, Yuanjing Lin, Jagan Mohan Dodda   +7 more
wiley   +1 more source

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source

Designed Antimicrobial Peptides for Topical Treatment of Antibiotic Resistant Acne Vulgaris

, 2020
Acne vulgaris, caused by the Gram-positive bacterium Cutibacterium acnes, is a prevalent dermatologic condition with substantial cutaneous and psychological morbidity.
Kathryn W. Woodburn, Jesse Jaynes, L. Edward Clemens   +2 more
core   +1 more source

Mesoporous Silica Nanoparticles in Biomedicine: Advances and Prospects

Advanced Materials, EarlyView.
Mesoporous silica nanoparticles offer unique properties like high surface area, tunable pores, and functionalization. They excel in drug delivery, tissue engineering, and stimuli‐responsive therapies, enabling targeted and controlled treatments. With roles in cancer therapy and diagnostics, their clinical translation requires addressing challenges in ...
Miguel Manzano, María Vallet‐Regí
wiley   +1 more source