Results 141 to 150 of about 4,085,374 (386)

Global monitoring of antimicrobial resistance based on metagenomics analyses of urban sewage

Nature Communications, 2019
Antimicrobial resistance (AMR) is a serious threat to global public health, but obtaining representative data on AMR for healthy human populations is difficult. Here, we use metagenomic analysis of untreated sewage to characterize the bacterial resistome
R. Hendriksen, Patrick Munk, P. Njage, B. V. van Bunnik, L. McNally, O. Lukjancenko, Timo Röder, David F. Nieuwenhuijse, S. Pedersen, J. Kjeldgaard, R. Kaas, P. Clausen, J. Vogt, P. Leekitcharoenphon, M. G. van de Schans, T. Zuidema, A. M. de Roda Husman, Simon Rasmussen, Bent Petersen, C. Amid, G. Cochrane, Thomas Sicheritz-Pontén, H. Schmitt, Jorge Raul Matheu Alvarez, A. Aidara-Kane, S. J. Pamp, O. Lund, T. Hald, M. Woolhouse, M. Koopmans, H. Vigre, T. Petersen, F. Aarestrup   +32 more
semanticscholar   +1 more source

Restrictive antibiotic stewardship associated with reduced hospital mortality in gram-negative infection [PDF]

, 2017
Introduction: Antimicrobial stewardship has an important role in the control of Clostridium difficile infection (CDI) and antibiotic resistance. An important component of UK stewardship interventions is the restriction of broad-spectrum beta-lactam ...
Helps, Alieen, Irvine, Sharon C., Jones, Brian L., Ritchie, Neil D., Robb, Fiona, Seaton, R. Andrew   +5 more
core   +1 more source

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

Statewide analysis of NHSN antimicrobial use rate and standardized antimicrobial administration ratio (SAAR) 2017–2023, Tennessee

Antimicrobial Stewardship & Healthcare Epidemiology
Objective: To describe antimicrobial use in Tennessee from 2017 to 2023. Design: Retrospective analysis of antimicrobial use using data from the National Healthcare Safety Network (NHSN) Antimicrobial Use (AU) Option. Setting: Acute care and critical
Glodi Mutamba, Callyn Wren, Dipen Patel, Melphine Harriott, Christopher Evans   +4 more
doaj   +1 more source

Bio‐Responsive Hydrogel for Targeted on‐Demand Release of a Phage Cocktail for Treatment of Pseudomonas aeruginosa Infection

Advanced Functional Materials, EarlyView.
This study presents an injectable hydrogel that responds to Pseudomonas aeruginosa infection by releasing a dual‐phage cocktail on demand. The system degrades selectively in infected wounds, enhances phage localization and stability, and shows potent antibiofilm activity and biocompatibility in an ex vivo human skin model—offering a promising strategy ...
Siyuan Tao, Anna Hu, Elnaz Bavel, Chien‐Hsun Yu, Sixuan Zhang, Vera Maria Kissling, Zhihao Li, Thomas Fintan Moriaty, Katharina Maniura‐Weber, Qun Ren   +9 more
wiley   +1 more source

Severe co-infection caused by difficult-to-diagnose hypermucoviscous Klebsiella pneumoniae K1-ST82 in a patient with COVID-19: a case report

BMC Infectious Diseases
Background Co-infection with Klebsiella pneumoniae presents a significant concern in hospitalized patients with coronavirus disease (COVID-19), increasing the risk of severe disease progression. Hypervirulent (hv) and hypermucoviscous (hm) K. pneumoniae (
Masamichi Itoga, Wataru Hayashi, Shizuo Kayama, Liansheng Yu, Yo Sugawara, Masahiko Kimura, Hiroyuki Hanada, Sadatomo Tasaka, Motoyuki Sugai   +8 more
doaj   +1 more source

Biosupercapacitors for Human‐Powered Electronics

Advanced Functional Materials, EarlyView.
Biosupercapacitors are emerging as biocompatible and integrative energy systems for next‐generation bioelectronics, offering rapid charge–discharge performance and mechanical adaptability. This review systematically categorizes their applications from external to organ‐level systems and highlights their multifunctional roles in sensing, actuation, and ...
Suhyeon Kim, Seungho Baek, Woojung Jung, Hayeon Bae, Junyoung Mun, Yong Ho Kim, Sunkook Kim, Jung Ho Kim   +7 more
wiley   +1 more source

Human-wildlife ecological interactions shape Escherichia coli population and resistome in two sloth species from Costa Rica

npj Antimicrobials and Resistance
Antimicrobial resistance (AMR) is a global health concern, with natural ecosystems acting as reservoirs for resistant bacteria. We assessed AMR in Escherichia coli isolated from two wild sloth species in Costa Rica. E.
Cristina Calvo-Fernandez, Marta M. Dolcet-Negre, Barbara Martin-Maldonado, Mario Pulido-Vadillo, Natalia Montero, Roger Such, Encarnación García-Vila, Jose F. Delgado-Blas, Bruno Gonzalez-Zorn   +8 more
doaj   +1 more source

The European Union summary report on antimicrobial resistance in zoonotic and indicator bacteria from humans, animals and food in 2017

EFSA journal. European Food Safety Authority, 2019
The data on antimicrobial resistance in zoonotic and indicator bacteria in 2017, submitted by 28 EU Member States (MSs), were jointly analysed by EFSA and ECDC.
P. Beloeil, B. Guerra, A. Stoicescu, K. Mulligan, K. Nagy, Gina Cioacata   +5 more
semanticscholar   +1 more source

Nanoparticles Decorated Nanotubes: Advanced Local Therapies From Anodized Nanoengineered Titanium Implants

Advanced Functional Materials, EarlyView.
This comprehensive review explores therapeutic titanium implants designed to enhance integration and provide superior antibacterial efficacy. It is focused on anodized titanium implants with titania nanotubes (TNTs) loaded with nanoparticles (NPs) for local therapeutic release, enhancing bioactivity and bactericidal functions.
Divya Chopra, Liwen Zhang, Tianqi Guo, Sašo Ivanovski, Ruirui Qiao, Karan Gulati   +5 more
wiley   +1 more source