Results 141 to 150 of about 1,194,702 (315)

AI‐Designed TREM1‐Targeted LYTAC Nanoparticles Reprogram the Neuroimmune Microenvironment in Traumatic Brain Injury

Advanced Science, EarlyView.
AI‐enabled de novo design of a TREM1 binder, integrated into a BBB‐crossing and macrophage‐targeted nanoplatform, enables TREM1 degradation and attenuates neuroinflammation, thereby promoting neuroprotection and tissue repair after traumatic brain injury. ABSTRACT Secondary neuroinflammation drives progressive damage after traumatic brain injury (TBI),
Yimin Huang, Yuan Liu, Huan Peng, Yu Ni, Zhengqiao Jiang, Chenxuan Yu, Xincheng Zhang, Huayu Kang, Yanchao Liu, Juan Chen, Kai Zhao, Lin Han, Xin Zou, Kai Shu, Xiaochuan Wang, Jian‐Zhi Wang, Ting Lei, Chao Gan, Jianfeng Liu, Huaqiu Zhang   +19 more
wiley   +1 more source

Correlation between carbapenem susceptibility in Pseudomonas aeruginosa and modified antibiotic heterogeneity index: a multicenter observational study using a surveillance platform

Antimicrobial Stewardship & Healthcare Epidemiology
Objective: This study focused on exploring the relationship between antimicrobial use indicators, including the modified antibiotic heterogeneity index (mAHI), and the carbapenem susceptibility in Pseudomonas aeruginosa.
Keisuke Sawada, Takaaki Kato, Shuji Kono, Hiromi Kaneko, Hayato Nakano, Shinobu Inada, Tatsuya Isogawa, Tadahiro Shimizu, Namiko Takahashi, Haruki Takano, Hiroaki Chiba, Makoto Sugimoto, Ryo Inose, Yuichi Muraki, Hideki Araoka   +14 more
doaj   +1 more source

Molecular Antimicrobial Susceptibility Testing in Sepsis

Future Microbiology
Rapidly detecting and identifying pathogens is crucial for appropriate antimicrobial therapy in patients with sepsis. Conventional diagnostic methods have been a great asset to medicine, though they are time consuming and labor intensive. This work will enable healthcare professionals to understand the bacterial community better and enhance their ...
Ignacio Martin-Loeches, João Gonçalves Pereira, Tee Keat Teoh, Gavin Barlow, Laurent Dortet, Enitan D Carrol, Ulrike Olgemöller, Sara E Boyd, Julien Textoris   +8 more
openaire   +3 more sources

Trends towards Lower Antimicrobial Susceptibility and Characterization of Acquired Resistance among Clinical Isolates of Brachyspira hyodysenteriae in Spain

, 2011
The antimicrobial susceptibility of clinical isolates of Brachyspira hyodysenteriae in Spain was monitored, and the underlying molecular mechanisms of resistance were investigated.
Sveriges lantbruksuniversitet., Pringle, Märit,   +1 more
core   +1 more source

Wearable E‐Textiles for Cardiovascular Monitoring: Materials, Devices, and Integrated Systems

Advanced Science, EarlyView.
The graphical abstract highlights the role of conductive materials and textile fabrication techniques in enabling smart textiles for cardiovascular applications. It showcases textile‐based ECG monitoring, pulse sensing, hemodynamic monitoring, and cardiovascular tissue engineering, while emphasizing the challenges and design considerations that govern ...
Bangul Khan, Mahmoud Tavakoli, Norbert Radacsi, Bee Luan KHOO   +3 more
wiley   +1 more source

The Potential of Self‐Maintainable Living Materials

Advanced Science, EarlyView.
Self‐maintainable living materials are presented as the next generation of bioadaptive systems, integrating continuous sensing, decision‐making, response, self‐repair, and adaptation in a closed‐loop framework. This review highlights the design principles and emerging technologies that enable autonomous, long‐term functionality for future regenerative ...
Mohammadsadegh Nadimifar, Tatiane Eufrásio‐da‐Silva, Lidia Maeso, Gorka Orive, Alireza Dolatshahi‐Pirouz   +4 more
wiley   +1 more source

Bacterial profile and antimicrobial susceptibility patterns among patients clinically suspected of bacterial conjunctivitis at the ophthalmologic clinic of Jimma Medical Center, Southwest Ethiopia

Frontiers in Tropical Diseases
BackgroundBacterial conjunctivitis is a significant cause of ocular morbidity globally, with increasing antimicrobial resistance posing a challenge to effective treatment.
Eyosias Teklemariam, Mekonnen Damessa, Mamo Nigatu, Bikila Alemu, Kumale Tolesa, Daba Abdissa, Korinan Fanta   +6 more
doaj   +1 more source

Nanoscale Buried Interface Control in Silicone Hydrogels Enables a Biointerface Engineering Platform

Advanced Science, EarlyView.
A hydrophilic coating with controllable nanoscale thickness is applied to commercial silicone hydrogel contact lenses. By combining comprehensive multi‐modal three‐dimensional characterization with an advanced algorithm, the thickness and chemical information of these multilayered structures are resolved.
Po‐Hsiang Chen, Jia‐Hua Wang, Ching Chen, Shih‐Hsuan Fu, Rajan Deepan Chakravarthy, Hsin‐Chieh Lin   +5 more
wiley   +1 more source

Immune Biomarkers of Islet Transplant Rejection Revealed by Synthetic Immunological Niche

Advanced Science, EarlyView.
A subcutaneous synthetic immunological niche (IN) enables serial, minimally invasive monitoring of immune responses after islet transplantation. Flow cytometry and transcriptomic profiling of the IN reveal immune‐cell programs associated with graft acceptance and distinct types of rejection.
Jyotirmoy Roy, Abdalmonam Jadou Nejma, Mohammad Tarique, Amod Talekar, Shengli Wu, Brianna Ha, Yifei Jiang, Esma S. Yolcu, Lonnie D. Shea   +8 more
wiley   +1 more source

Comparison of Antimicrobial Susceptibility Patterns of Bacterial Isolates from Blood, Urine, and Lower Respiratory Tract Specimens Between Elderly Patients in Long-Term Care Hospitals and Community-Acquired Infections: A Retrospective Study

Antibiotics
Background/Objectives: Patients in long-term care hospitals (LTCHs) are at increased risk of harboring antimicrobial-resistant organisms due to frequent healthcare exposure and multiple comorbidities.
Kye Won Choe, Sumi Yoon, Yong Kwan Lim, Hongkyung Kim, Mi-Kyung Lee, Oh Joo Kweon   +5 more
doaj   +1 more source