Results 1 to 10 of about 2,981,481 (308)

Reprogrammed SimCells for antimicrobial therapy. [PDF]

Proc Natl Acad Sci U S A
Antimicrobial resistance (AMR) is a critical global health challenge. In this study, we developed a novel platform based on chromosome-free and non-replicating simple cells (SimCells, size 1-2 μm) and mini-SimCells (size 100-400 nm) for targeted pathogen elimination.
Dong Y, Ji X, Dong T, Wang Y, Bakkeren E, Foster KR, Huang WE.   +6 more
europepmc   +4 more sources

Molecular Epidemiology, Antimicrobial Surveillance, and PK/PD Analysis to Guide the Treatment of Neisseria gonorrhoeae Infections

Pharmaceutics, 2021
The aim of this study was to apply molecular epidemiology, antimicrobial surveillance, and PK/PD analysis to guide the antimicrobial treatment of gonococci infections in a region of the north of Spain.
Rodrigo Alonso, Ainara Rodríguez-Achaerandio, Amaia Aguirre-Quiñonero, Aitor Artetxe, Ilargi Martínez-Ballesteros, Alicia Rodríguez-Gascón, Javier Garaizar, Andrés Canut   +7 more
doaj   +1 more source

Optimizing Antimicrobial Therapy by Integrating Multi-Omics With Pharmacokinetic/Pharmacodynamic Models and Precision Dosing

Frontiers in Pharmacology, 2022
In the era of “Bad Bugs, No Drugs,” optimizing antibiotic therapy against multi-drug resistant (MDR) pathogens is crucial. Mathematical modelling has been employed to further optimize dosing regimens.
Hui-Yin Yow, Hui-Yin Yow, Kayatri Govindaraju, Audrey Huili Lim, Nusaibah Abdul Rahim   +4 more
doaj   +1 more source

Antimicrobial resistance monitoring: a review of information resources

Бюллетень сибирской медицины, 2020
In the last decades, the problem of antibiotic resistance occupies one of the key positions in the global public health system and requires attention from the medical community.
A. Yu. Kuzmenkov, A. G. Vinogradova
doaj   +1 more source

Characterization of bla TEM and bla CTX-M beta-lactam resistance genes in chronic rhinosinusitis

Egyptian Journal of Medical Human Genetics, 2023
Background Chronic sinusitis is one of the most challenging health problems of contemporary society. Although several treatment methods have been defined, a comprehensive understanding of the underlying causes (e.g., antibiotic resistance) is still ...
Mojdeh Arian Nejad, Milad Sabaei, Alireza Ahmadi, Sara Minaeian, Danesh Amin Panah, Kimia Mozahheb Yousefi   +5 more
doaj   +1 more source

A rare complication of otitis media: Gradenigo's syndrome successfully managed on outpatient antimicrobial therapy

Clinical Infection in Practice, 2020
We report a case of Gradenigo's syndrome successfully managed on an outpatient parenteral antibiotic service. This condition is classically described as a triad of otorrhoea, facial pain in the distribution of the trigeminal nerve and ipsilateral ...
Conor Bowman, Nada Nakhla, Victoria Amedu, Parag Patel, Ciara O'Connor, Angela Houston, Aodhan Breathnach   +6 more
doaj   +1 more source

Critical Care in Cardiac Surgery Patients with COVID-19: International and Own Experience

Український журнал серцево-судинної хірургії, 2021
The widespread occurrence of coronavirus disease 2019 (COVID-19) in the world has led to a sharp de-crease in the number of cardiac surgery interventions and had a negative impact on treatment outcomes.
G. B. Koltunova, L. M. Avramenko, V. V. Voityuk, K. P. Chyzh   +3 more
doaj   +1 more source

Antimicrobial Therapy and Antimicrobial Stewardship in Sepsis

Infection & Chemotherapy, 2020
Since sepsis was first defined, sepsis management has remained challenging. To improve mortality rates for sepsis and septic shock, an accurate diagnosis and prompt administration of appropriate antibiotics are essential. The goals of antimicrobial stewardship are to achieve optimal clinical outcomes and to ensure cost-effectiveness and minimal ...
Hyeri Seok, Ji Hoon Jeon, Dae Won Park
openaire   +2 more sources

Antimicrobial resistance monitoring of potential pathogens causing bloodstream infections

Инфекция и иммунитет, 2022
Microbiological monitoring, being an integral component of epidemiological surveillance of healthcare associated infection (HAI), is one of the most important components in hospital patient safety.
A. S. Zakhvatova, M. G. Daryina, Y. S. Svetlichnaya, L. P. Zueva, B. I. Aslanov, M. A. Chervyakova   +5 more
doaj   +1 more source

Specific features of antimicrobial therapy in patients with severe respiratory failure receiving veno-venous extracorporeal membrane oxygenation (ECMO) [PDF]

Клиническая микробиология и антимикробная химиотерапия, 2023
In modern medicine, the extracorporeal membrane oxygenation (ECMO) is becoming increasingly common in the treatment of severe respiratory failure. The development of infectious complications in patients receiving ECMO often leads to an increase in the ...
Petrushin M.A., Melnichenko P.I., Vlasov P.A., Nikiforov I.S., Kudryashova E.A., Glushchenko I.A.   +5 more
doaj   +1 more source