Results 41 to 50 of about 2,981,481 (308)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Emerging Carbapenem-Resistant Enterobacteriaceae Infection, Its Epidemiology and Novel Treatment Options: A Review

Infection and Drug Resistance, 2021
Mihret Tilahun, Yeshimebet kassa, Alemu Gedefie, Melaku Ashagire Department of Medical Laboratory Sciences, College of Medicine and Health Science, Wollo University, Dessie, EthiopiaCorrespondence: Mihret TilahunDepartment of Medical Laboratory Science ...
Tilahun M, kassa Y, Gedefie A, Ashagire M   +3 more
doaj  

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Clinical Decision-making for Anti-infective Therapy in Patients with Positive Blood Cultures

Xiehe Yixue Zazhi
Bloodstream infections(BSIs) are associated with high morbidity and mortality. The widespread emergence of antimicrobial resistance has significantly increased the complexity of treating BSIs, making the development of precise antimicrobial treatment ...
SHI Yan, MA Xiaojun
doaj   +1 more source

Multidisciplinary Approach in the Treatment of Descending Necrotizing Mediastinitis: Twenty-Year Single-Center Experience

Antibiotics, 2022
Descending necrotizing mediastinitis (DNM) is an acute, rare, severe condition with high mortality, but the optimal management protocol is still controversial.
Angela De Palma, Mirko Girolamo Cantatore, Francesco Di Gennaro, Francesca Signore, Teodora Panza, Debora Brascia, Giulia De Iaco, Doroty Sampietro, Rosatea Quercia, Marcella Genualdo, Ondina Pizzuto, Giuseppe Garofalo, Fabio Signorile, Davide Fiore Bavaro, Gaetano Brindicci, Nicolò De Gennaro, Annalisa Saracino, Nicola Antonio Adolfo Quaranta, Gianfranco Favia, Giuseppe Marulli   +19 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Risk Factors For Nosocomial Pan Drug Resistant Acinetobacter Baumannii Infections

Acta Medica Alanya, 2019
Aim: Acinetobacter baumannii is an important nosocomial pathogen. The purpose of this study was to identify risk factors and mortality of nosocomial infections caused by pan drug resistant (PDR) Acinetobacter baumannii and to characterize their effects ...
Havva Tünay, Tuna Demi̇rdal, Neşe Demi̇rtürk   +2 more
doaj   +1 more source

A Proposal for a Classification Guiding the Selection of Appropriate Antibiotic Therapy for Intra-Abdominal Infections

Antibiotics, 2022
Adequately controlling the source of infection and prescribing appropriately antibiotic therapy are the cornerstones of the management of patients with intra-abdominal infections (IAIs).
Massimo Sartelli, Francesco Cristini, Federico Coccolini, Francesco Maria Labricciosa, Walter Siquini, Fausto Catena   +5 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Problems of poststreptococcal diseases primary prophylaxis - lessons of a multicenter study management practice of patients with acute tonsillitis

Научно-практическая ревматология, 2005
Objective. To evaluate the actual practice of diagnostics and treatment of patients with acute tonsillitis in order to assess the quality of primary prophylaxis of poststreptococcal diseases in different regions of Russia. Material and methods.
S. N. Kozlov, L S Strachunsky, S. A. Rachina   +2 more
doaj   +1 more source