Results 61 to 70 of about 251,321 (315)

Time-Kill Evaluation of Antibiotic Combinations Containing Ceftazidime-Avibactam against Extensively Drug-Resistant Pseudomonas aeruginosa and Their Potential Role against Ceftazidime-Avibactam-Resistant Isolates

Microbiology Spectrum, 2021
Ceftazidime-avibactam (CZA) has emerged as a promising solution to the lack of new antibiotics against Pseudomonas aeruginosa infections. Data from in vitro assays of CZA combinations, however, are scarce. The objective of our study was to perform a time-
María M. Montero, Sandra Domene Ochoa, Carla López-Causapé, Sonia Luque, Luisa Sorlí, Núria Campillo, Inmaculada López Montesinos, Eduardo Padilla, Núria Prim, Ariadna Angulo-Brunet, Santiago Grau, Antonio Oliver, Juan P. Horcajada   +12 more
doaj   +1 more source

Antimicrobials in animal agriculture: Parables and policy [PDF]

, 2015
In addition to the scientific, economic, regulatory and other policy factors that impact on antimicrobial decision-making in different jurisdictions around the world, there exist ethical, social and cultural bases for the contemporary use of these ...
Aarestrup, Aarestrup, Aarestrup, Aarestrup, Alali, Amachawadi, Bunner, Cavaco, Checkland, Cottell, Dean, Doyle, Dutil, Food and Drug Administration, Food and Drug Administration, Food and Drug Administration, Food and Drug Administration, G. H. Loneragan, G. Midgley, H. M. Scott, H. Morgan Scott, Hollway, Hurd, Hurd, Jaap A. Wagenaar, Jan, Jan, Kanwar, Kanwar, Keelara, Lowrance, Maturana, McIntosh, Midgley, Midgley, Midgley, Midgley, Platt, Popper, Ulrich, Von Foerster, Von Glasersfeld, World Health Organization, World Health Organization   +43 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Enhancing the Therapeutic Potential of Peptide Antibiotics Using Bacteriophage Mimicry Strategies

Advanced Science
The rise of antibiotic resistance, coupled with a dwindling antibiotic pipeline, presents a significant threat to public health. Consequently, there is an urgent need for novel therapeutics targeting antibiotic‐resistant pathogens.
Hongping Wan, Xinyi Zhong, Shinong Yang, Jiarong Deng, Xu Song, Yong Liu, Yuanfeng Li, Zhongqiong Yin, Xinghong Zhao   +8 more
doaj   +1 more source

Perturbed structural dynamics underlie inhibition and altered efflux of the multidrug resistance pump AcrB

Nature Communications, 2020
AcrB is a prototypical resistance–nodulation–division (RND) bacterial transporter, conferring resistance to a variety of antibiotics. HDX-MS and other, complementary approaches offer insight into AcrB structural dynamics and suggest the molecular ...
Eamonn Reading, Zainab Ahdash, Chiara Fais, Vito Ricci, Xuan Wang-Kan, Elizabeth Grimsey, Jack Stone, Giuliano Malloci, Andy M. Lau, Heather Findlay, Albert Konijnenberg, Paula J. Booth, Paolo Ruggerone, Attilio V. Vargiu, Laura J. V. Piddock, Argyris Politis   +15 more
doaj   +1 more source

Antimicrobials in Dentistry

Applied Sciences, 2021
Dental caries (decay) is caused by pathogenic bacterial species, which afflicts nearly a third of the world’s population from early childhood to old age. Treatment of tooth decay often involves the use of filling materials to restore the cavity; however,
Rana Alkattan, Luis Rojo, Sanjukta Deb
doaj   +1 more source

Comparative analysis of Salmonella susceptibility and tolerance to the biocide chlorhexidine identifies a complex cellular defense network [PDF]

, 2014
peer-reviewedChlorhexidine is one of the most widely used biocides in health and agricultural settings as well as in the modern food industry. It is a cationic biocide of the biguanide class. Details of its mechanism of action are largely unknown.
Aine eSheridan, Catherine Maeve Burgess, Jarlath eNally, Jay C. D. Hinton, Jay C. D. Hinton, Jenny eRenaut, Karen ePower, Kjell eSergeant, Kristian eHandler, Orla eCondell, Orla eCondell, Sarah eFinn, Seamus eFanning, Seamus eFanning   +13 more
core   +2 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Prescribing practices of primary-care veterinary practitioners in dogs diagnosed with bacterial pyoderma [PDF]

, 2014
Concern has been raised regarding the potential contributions of veterinary antimicrobial use to increasing levels of resistance in bacteria critically important to human health.
A Hillier, A Mateus, A Wayne, AD Radford, AD Watson, Anke Hendricks, B Kirkwood, C Noli, CP Murphy, David C Brodbelt, DL Wells, DW Scott, DW Scott, EJ Pleydell, EM Lund, FC Tenover, IS Mason, J Bannoehr, J Cd, Jennifer F Summers, JF Summers, JR Fitzgerald, JS Weese, K Gortel, K Odensvik, L Beco, L Beco, LA Hughes, LM Freeman, LS Barter, M Escher, M Rantala, N Murayama, National Organisation of Animal Health (Great Britain) (NOAH), OM Briggs, PB Hill, PB Hill, PJ Ihrke, RK Anderson, T Sasaki, VJ Adams, WM Sischo   +41 more
core   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source