Results 51 to 60 of about 251,321 (315)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Hearing loss and cochlear damage in experimental pneumococcal meningitis, with special reference to the role of neutrophil granulocytes

Neurobiology of Disease, 2006
Hearing loss is a well-known sequelae from meningitis, affecting up to 25% of survivors. However, the principal components of the infectious and inflammatory reaction responsible for the sensorineural hearing loss remain to be identified.The present ...
C.T. Brandt, P. Cayé-Thomasen, S.P. Lund, L. Worsøe, C. Østergaard, N. Frimodt-Møller, F. Espersen, J. Thomsen, J.D. Lundgren   +8 more
doaj   +1 more source

Antisense PNA accumulates in Escherichia coli and mediates a long post-antibiotic effect [PDF]

, 2007
Antisense agents that target growth-essential genes display surprisingly potent bactericidal properties. In particular, peptide nucleic acid (PNA) and phosphorodiamidate morpholino oligomers linked to cationic carrier peptides are effective in time kill ...
Behmanesh, Mehrdad, Dryselius, Rikard, Faridani, Omid R, Ganyu, Anita, Goh, Shan, Good, Liam, Klok, Erik Jan, Nikravesh, Abbas, Sadeghizadeh, Majid, Zain, Rula   +9 more
core   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Origins and breadth of pairwise epistasis in an α-helix of β-lactamase TEM-1

Nature Communications
The effect of mutations in a protein may depend on the presence of others—a phenomenon known as epistasis. Epistasis plays a key role in evolution and complicates predictions of mutational effects, as effects can be context-dependent.
André Birgy, Clément Roussel, Harry Kemble, Jimmy Mullaert, Karine Panigoni, Audrey Chapron, Mélanie Magnan, Hervé Jacquier, Simona Cocco, Rémi Monasson, Olivier Tenaillon   +10 more
doaj   +1 more source

The Mobilome; A Major Contributor to Escherichia coli stx2-Positive O26:H11 Strains Intra-Serotype Diversity

Frontiers in Microbiology, 2017
Shiga toxin-producing Escherichia coli of serotype O26:H11/H- constitute a diverse group of strains and several clones with distinct genetic characteristics have been identified and characterized.
Sabine Delannoy, Patricia Mariani-Kurkdjian, Patricia Mariani-Kurkdjian, Patricia Mariani-Kurkdjian, Hattie E. Webb, Stephane Bonacorsi, Stephane Bonacorsi, Stephane Bonacorsi, Patrick Fach   +8 more
doaj   +1 more source

Antimicrobial use in pigs, broilers and veal calves in Belgium [PDF]

, 2014
Given the risks associated with antimicrobial resistance and its link with antimicrobial use, available data on antimicrobial use in the Belgian pig, broiler and veal calf production were compared. Allowing for comparison of the data available from three
Callens, Benedicte, Dewulf, Jeroen, Filippitzi, Maria-Eleni, Pardon, Bart, Persoons, Davy   +4 more
core  

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Modeling the transmission of antibiotic-resistant Enterobacterales in the community: A systematic review

Epidemics
Background: Antibiotic-resistant Enterobacterales (ARE) are a public health threat worldwide. Dissemination of these opportunistic pathogens has been largely studied in hospitals.
Eve Rahbé, Philippe Glaser, Lulla Opatowski   +2 more
doaj   +1 more source

Intrapulmonary concentrations of meropenem administered by continuous infusion in critically ill patients with nosocomial pneumonia: a randomized pharmacokinetic trial

Critical Care, 2020
Background Optimal antimicrobial drug exposure in the lung is required for successful treatment outcomes for nosocomial pneumonia. Little is known about the intrapulmonary pharmacokinetics (PK) of meropenem when administered by continuous infusion (CI ...
Adela Benítez-Cano, Sonia Luque, Luisa Sorlí, Jesús Carazo, Isabel Ramos, Nuria Campillo, Víctor Curull, Albert Sánchez-Font, Carles Vilaplana, Juan P. Horcajada, Ramón Adalia, Silvia Bermejo, Enric Samsó, William Hope, Santiago Grau   +14 more
doaj   +1 more source