Results 31 to 40 of about 138,355 (267)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Guiding antibiotics towards their target using bacteriophage proteins

Nature Communications
Novel therapeutic strategies against difficult-to-treat bacterial infections are desperately needed, and the faster and cheaper way to get them might be by repurposing existing antibiotics.
Xinghong Zhao, Xinyi Zhong, Shinong Yang, Jiarong Deng, Kai Deng, Zhengqun Huang, Yuanfeng Li, Zhongqiong Yin, Yong Liu, Jakob H. Viel, Hongping Wan   +10 more
doaj   +1 more source

Optimization of Independent Variables for the Production of Extracellular Alpha Amylase by Bacillus subtilis IMD34 Using Plackett-Burman Design

Sultan Qaboos University Journal for Science
Bacillus species are widely used for thermostable α-amylase production for various applications such as in the detergent and food industries. This research aimed to study the production of α-amylase by B.
Henshaw Effiom, Josiah Lennox
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Origins and breadth of pairwise epistasis in an α-helix of β-lactamase TEM-1

Nature Communications
The effect of mutations in a protein may depend on the presence of others—a phenomenon known as epistasis. Epistasis plays a key role in evolution and complicates predictions of mutational effects, as effects can be context-dependent.
André Birgy, Clément Roussel, Harry Kemble, Jimmy Mullaert, Karine Panigoni, Audrey Chapron, Mélanie Magnan, Hervé Jacquier, Simona Cocco, Rémi Monasson, Olivier Tenaillon   +10 more
doaj   +1 more source

Hearing loss and cochlear damage in experimental pneumococcal meningitis, with special reference to the role of neutrophil granulocytes

Neurobiology of Disease, 2006
Hearing loss is a well-known sequelae from meningitis, affecting up to 25% of survivors. However, the principal components of the infectious and inflammatory reaction responsible for the sensorineural hearing loss remain to be identified.The present ...
C.T. Brandt, P. Cayé-Thomasen, S.P. Lund, L. Worsøe, C. Østergaard, N. Frimodt-Møller, F. Espersen, J. Thomsen, J.D. Lundgren   +8 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

The Mobilome; A Major Contributor to Escherichia coli stx2-Positive O26:H11 Strains Intra-Serotype Diversity

Frontiers in Microbiology, 2017
Shiga toxin-producing Escherichia coli of serotype O26:H11/H- constitute a diverse group of strains and several clones with distinct genetic characteristics have been identified and characterized.
Sabine Delannoy, Patricia Mariani-Kurkdjian, Patricia Mariani-Kurkdjian, Patricia Mariani-Kurkdjian, Hattie E. Webb, Stephane Bonacorsi, Stephane Bonacorsi, Stephane Bonacorsi, Patrick Fach   +8 more
doaj   +1 more source

Antimicrobials in Dentistry

Applied Sciences, 2021
Dental caries (decay) is caused by pathogenic bacterial species, which afflicts nearly a third of the world’s population from early childhood to old age. Treatment of tooth decay often involves the use of filling materials to restore the cavity; however,
Rana Alkattan, Luis Rojo, Sanjukta Deb
doaj   +1 more source