Results 21 to 30 of about 133,631 (265)

Evolution of Antimicrobial Consumption During the First Wave of COVID-19 Pandemic

Antibiotics, 2021
Background: The first wave of COVID-19 pandemic may have significantly impacted antimicrobial consumption in hospitals. The objective of this study was to assess the evolution of antimicrobial consumption during this period.
Santiago Grau, Daniel Echeverria-Esnal, Silvia Gómez-Zorrilla, Maria Eugenia Navarrete-Rouco, Joan Ramon Masclans, Merce Espona, Maria Pilar Gracia-Arnillas, Xavier Duran, Merce Comas, Juan Pablo Horcajada, Olivia Ferrández   +10 more
doaj   +1 more source

Antimicrobial peptides [PDF]

Current Biology, 2016
Antimicrobial peptides and proteins (AMPs) are a diverse class of naturally occurring molecules that are produced as a first line of defense by all multicellular organisms. These proteins can have broad activity to directly kill bacteria, yeasts, fungi, viruses and even cancer cells.
Zhang, Ling-juan, Gallo, Richard L.
openaire   +2 more sources

Studying Lipid Membrane Interactions of a Super-Cationic Peptide in Model Membranes and Living Bacteria

Pharmaceutics, 2022
The super-cationic peptide dendrimers (SCPD) family is a valuable class of antimicrobial peptide candidates for the future development of antibacterial agents against multidrug-resistant gram-negative bacteria.
Isabel Pérez-Guillén, Òscar Domènech, Adrià Botet-Carreras, Alexandra Merlos, Josep M. Sierra, Fernando Albericio, Beatriz G. de la Torre, M. Teresa Montero, Miguel Viñas, Jordi H. Borrell   +9 more
doaj   +1 more source

Investigating the feasibility and potential of combining industry AMR monitoring systems: a comparison with WHO GLASS [version 2; peer review: 2 approved]

Wellcome Open Research
Background Efforts to estimate the global burden of antimicrobial resistance (AMR) have highlighted gaps in existing surveillance systems. Data gathered from hospital networks globally by pharmaceutical industries to monitor antibiotic efficacy in ...
Aleksandra Kovacevic, Eve Rahbé, Quentin J. Leclerc, Lulla Opatowski   +3 more
doaj   +1 more source

Er,Cr:YSGG Laser-Activation Enhances Antimicrobial and Antibiofilm Action of Low Concentrations of Sodium Hypochlorite in Root Canals

Antibiotics, 2019
The onset and persistence of endodontic infections due to residual biofilm after chemical disinfection promotes secondary bacterial infection. Alternative methods to disinfect operated root canals are a matter of great interest.
Pablo Betancourt, Josep María Sierra, Octavi Camps-Font, Josep Arnabat-Domínguez, Miguel Viñas   +4 more
doaj   +1 more source

Chlorpromazine and Amitriptyline Are Substrates and Inhibitors of the AcrB Multidrug Efflux Pump

mBio, 2020
Efflux is an important mechanism in Gram-negative bacteria conferring multidrug resistance. Inhibition of efflux is an encouraging strategy to restore the antibacterial activity of antibiotics.
Elizabeth M. Grimsey, Chiara Fais, Robert L. Marshall, Vito Ricci, Maria Laura Ciusa, Jack W. Stone, Alasdair Ivens, Giuliano Malloci, Paolo Ruggerone, Attilio V. Vargiu, Laura J. V. Piddock   +10 more
doaj   +1 more source

Impact of ceftolozane/tazobactam concentrations in continuous infusion against extensively drug-resistant Pseudomonas aeruginosa isolates in a hollow-fiber infection model

Scientific Reports, 2021
Ceftolozane/tazobactam (C/T) has emerged as a potential agent for the treatment of extensively drug-resistant (XDR) Pseudomonas aeruginosa infections.
María M. Montero, Sandra Domene-Ochoa, Carla López-Causapé, Sonia Luque, Luisa Sorlí, Núria Campillo, Eduardo Padilla, Núria Prim, Lorena Ferrer-Alapont, Ariadna Angulo-Brunet, Santiago Grau, Antonio Oliver, Juan P. Horcajada   +12 more
doaj   +1 more source

Green Antimicrobials

Antibiotics, 2023
In the last couple of years, the awareness of climate change and high pollution levels have raised our sense of ecological responsibility [...]
Helena P. Felgueiras
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

AmpHGT: expanding prediction of antimicrobial activity in peptides containing non-canonical amino acids using multi-view constrained heterogeneous graph transformer

BMC Biology
Background Antimicrobial peptide (AMP) prediction has been extensively studied in recent years. However, many existing models do not fully leverage the intrinsic chemical structures of AMPs, such as atomic composition and sidechain group characteristics.
Yongcheng He, Xu Song, Hongping Wan, Xinghong Zhao   +3 more
doaj   +1 more source