Results 21 to 30 of about 1,021 (176)

Bronchoalveolar Lavage Fluid Metagenomic Second-Generation Sequencing Assists in Guiding the Treatment of Visceral Leishmaniasis: A Case Report. [PDF]

Infect Drug Resist
Jian Li,1,* Li Liu,2,* Zhiyun Gao,1 Xia Chuai,3 Xiaokun Liu,4 Xiaobo Zhang,2 Xinyu Zhang,2 Xiaoqing Su,2 Qian Xu,2 Zhuojun Deng2 1Department of Pathogenic Biology, Hebei Medical University, Shijiazhuang, Hebei, People’s Republic of China ...
Li J, Liu L, Gao Z, Chuai X, Liu X, Zhang X, Zhang X, Su X, Xu Q, Deng Z.   +9 more
europepmc   +2 more sources

Treatment of leishmaniasis with chemotherapy and vaccine: a mathematical model

Journal of Biological Dynamics, 2023
Leishmaniasis, an infectious disease, manifests itself mostly in two forms, cutaneous leishmaniasis (CL) and, a more severe and potentially deadly form, visceral leishmaniasis (VL).
Nourridine Siewe, Avner Friedman
doaj   +1 more source

Therapeutic modalities in post kala-azar dermal leishmaniasis: A systematic review of the effectiveness and safety of the treatment options

Indian Journal of Dermatology, 2021
Post-kala-azar dermal Leishmaniasis (PKDL) is one of the important neglected tropical diseases, which has a tremendous epidemiological significance, being the reservoir of kala-azar.
Adrija Datta, Indrashis Podder, Anupam Das, Amrita Sil, Nilay Kanti Das   +4 more
doaj   +1 more source

Antimony resistant Leishmania donovani but not sensitive ones drives greater frequency of potent T-regulatory cells upon interaction with human PBMCs: role of IL-10 and TGF-β in early immune response. [PDF]

PLoS Neglected Tropical Diseases, 2014
In India the sand fly, Phlebotomus argentipes, transmitted parasitic disease termed kala-azar is caused by Leishmania donovani (LD) in humans. These immune-evading parasites have increasingly developed resistance to the drug sodium antimony gluconate in ...
Rajan Guha, Shantanabha Das, June Ghosh, Shyam Sundar, Jean Claude Dujardin, Syamal Roy   +5 more
doaj   +1 more source

Runx proteins mediate protective immunity against Leishmania donovani infection by promoting CD40 expression on dendritic cells.

PLoS Pathogens, 2020
The level of CD40 expression on dendritic cells (DCs) plays a decisive role in disease protection during Leishmania donovani (LD) infection. However, current understanding of the molecular regulation of CD40 expression remains elusive.
Md Naushad Akhtar, Manish Mishra, Vinod Yadav, Manisha Yadav, Ravindra Gujar, Sunaina Lal, Raj Kumar, Neeraj Khatri, Pradip Sen   +8 more
doaj   +1 more source

Quantification of parasite load in clinical samples of leishmaniasis patients: IL-10 level correlates with parasite load in visceral leishmaniasis. [PDF]

PLoS ONE, 2010
A rapid and accurate method to detect and quantify Leishmania parasite is urgently needed to facilitate early diagnosis of leishmaniasis and monitoring of antileishmania therapy.
Sandeep Verma, Rajesh Kumar, Gajendra Kumar Katara, Laishram Chandreshwor Singh, Narender Singh Negi, V Ramesh, Poonam Salotra   +6 more
doaj   +1 more source

Over-Expression of Cysteine Leucine Rich Protein Is Related to SAG Resistance in Clinical Isolates of Leishmania donovani. [PDF]

PLoS Neglected Tropical Diseases, 2015
BACKGROUND:Resistance emergence against antileishmanial drugs, particularly Sodium Antimony Gluconate (SAG) has severely hampered the therapeutic strategy against visceral leishmaniasis, the mechanism of resistance being indistinguishable.
Sanchita Das, Priyanka Shah, Rati Tandon, Narendra Kumar Yadav, Amogh A Sahasrabuddhe, Shyam Sundar, Mohammad Imran Siddiqi, Anuradha Dube   +7 more
doaj   +1 more source

Molecular mechanisms of drug resistance in natural Leishmania populations vary with genetic background [PDF]

, 2012
The evolution of drug-resistance in pathogens is a major global health threat. Elucidating the molecular basis of pathogen drug-resistance has been the focus of many studies but rarely is it known whether a drug-resistance mechanism identified is ...
Sylke Müller, Hideo Imamura (62469), Dujardin, J., Khanal, Basudha, Brunker, K., Brunker, Kirstyn, Kirstyn Brunker (181178), Graham H. Coombs (164011), Suman Rijal (181185), Imamura, Hideo, Jean-Claude Dujardin, M\ufcller, Sylke, Dujardin, Jean-Claude, Dujardin, J. C., Coombs, G. H., Muller, S., Jean-Claude Dujardin (56958), Decuypere, S., Coombs, G.H., Vanaerschot, M., Decuypere, Saskia, Coombs, Graham H, Rijal, S., Manu Vanaerschot, Sylke Müller (37476), Basudha Khanal, Khanal, B., Hideo Imamura, Kirstyn Brunker, Müller, Sylke, Coombs, Graham H., Vanaerschot, Manu, Imamura, H., Rijal, Suman, Saskia Decuypere, Basudha Khanal (181181), Saskia Decuypere (181176), Manu Vanaerschot (109210), Suman Rijal, Graham H Coombs   +39 more
core   +1 more source

Improved kala-azar case management through implementation of health facility-based sentinel sites surveillance system in Bihar, India.

PLoS Neglected Tropical Diseases, 2021
BackgroundVisceral leishmaniasis (VL), also known as kala-azar (KA), is a neglected vector-borne disease, targeted for elimination, but several affected blocks of Bihar are posing challenges with the high incidence of cases, and moreover, the disease is ...
Vidya Nand Rabi Das, Niyamat Ali Siddiqui, Gouri Sankar Bhunia, Krishna Pandey, Sanjay Kumar Sinha, Md Zahid Ansari, Roshan Kamal Topno, Chandra Sekhar Lal, Alok Ranjan, Vijay Pratap Singh, Pradeep Das   +10 more
doaj   +1 more source

Comprehensive economic evaluation of thermotherapy for the treatment of cutaneous leishmaniasis in Colombia

BMC Public Health, 2018
Background Cutaneous leishmaniasis causes a high disease burden in Colombia, and available treatments present systemic toxicity, low patient compliance, contraindications, and high costs.
Jaiberth Antonio Cardona-Arias, Liliana López-Carvajal, Mery Patricia Tamayo-Plata, Iván Darío Vélez   +3 more
doaj   +1 more source