Results 31 to 40 of about 1,021 (176)

Metabolomics to unveil and understand phenotypic diversity between pathogen populations [PDF]

, 2010
Visceral leishmaniasis is caused by a parasite called Leishmania donovani, which every year infects about half a million people and claims several thousand lives. Existing treatments are now becoming less effective due to the emergence of drug resistance.
Breitling, Rainer,, Brunker, Kirstyn, Jean-Claude Dujardin, Breitling Rainer, Dujardin, Jean-Claude, Dujardin, Jean Claude, Scheltema, R.A., Coombs, Graham H.,, Rijal, Suman,, Brunker Kirstyn, Coombs, Graham H, Dujardin, J.-C., Rijal, S., Kirstyn Brunker, Coombs Graham H., Coombs, Graham H., Dujardin, Jean-Claude,, Dujardin Jean-Claude, Watson, David G, Jankevics, Andris,, Jankevics Andris, Saskia Decuypere, Watson, D.G., t'Kindt, R., Kindt, Ruben t’,, Suman Rijal, t'Kindt, Ruben, t'Kindt Ruben, Watson David G., Breitling, Rainer, Brunker, K., Breitling, R., Brunker, Kirstyn,, Scheltema Richard A., Jankevics, A., Richard A Scheltema, Geary, T.G., Rijal Suman, Decuypere, S., Graham H. Coombs, Coombs, G.H., Andris Jankevics, Decuypere, Saskia, Scheltema, Richard A, Scheltema, Richard A., David G. Watson, Watson, David G., Richard A. Scheltema, Rainer Breitling, Decuypere Saskia, Jankevics, Andris, Decuypere, Saskia,, Watson, David G.,, David G Watson, 't Kindt, Ruben, Rijal, Suman, Ruben t'Kindt, Scheltema, Richard A.,, Graham H Coombs   +58 more
core   +1 more source

Over-expression of 60s ribosomal L23a is associated with cellular proliferation in SAG resistant clinical isolates of Leishmania donovani.

PLoS Neglected Tropical Diseases, 2013
BackgroundSodium antimony gluconate (SAG) unresponsiveness of Leishmania donovani (Ld) had effectively compromised the chemotherapeutic potential of SAG.
Sanchita Das, Priyanka Shah, Rajendra K Baharia, Rati Tandon, Prashant Khare, Shyam Sundar, Amogh A Sahasrabuddhe, M I Siddiqi, Anuradha Dube   +8 more
doaj   +1 more source

Structures, targets and recent approaches in anti-leishmanial drug discovery and development. [PDF]

, 2011
Recent years have seen a significant improvement in available treatment options for leishmaniasis. Two new drugs, miltefosine and paromomycin, have been registered for the treatment of visceral leishmaniasis (VL) in India since 2002.
Karin Seifert, Seifert, Karin
core   +1 more source

In Vitro Low Responsiveness of Leishmania donovani Towards Sodium Antimony Gluconate

Bangladesh Journal of Medical Microbiology, 2016
Kala-azar has been uprising concomitantly with drug-resistant strains of the causatinve agent, particularly in the neighbouring India. The actual perspective of drug resistance in Leishmania donovani in Bangladesh is yet to be explored. So, this prospective study, as a preliminary one, was done to observe in vitro drug responsiveness against Sodium ...
Abdullah Akhtar Ahmed, Md. Akram Hossain, Mesbah Uddin Ahmed, Md Chand Mahmud, Abul Hossain Khan, AKM Musa, AKM Shamsuzzaman, Murshed Alam   +7 more
openaire   +2 more sources

Bioengineered 3D hPSC‐Cholangiocyte Ducts With Physiological Signals for Biliary Disease Modeling

Advanced Healthcare Materials, Volume 15, Issue 20, 27 May 2026.
Tian and colleagues generated a bioengineered bile duct from human pluripotent stem cell (hPSC)‐derived intrahepatic cholangiocytes within a high‐throughput, 384‐well platform to systematically examine the influence of biliary physiological signals including fluid flow, stromal cells and bile acids, and models intrahepatic biliary disease progression ...
Britney Tian, Mina Ogawa, Manami Kondo, Gabrielle Langeveld, Ling Jun Huan, Feng Zhang, Andrew Hollinger, Sara Deir, Christine Bear, Boyang Zhang, Shinichiro Ogawa   +10 more
wiley   +1 more source

Arginase activity - a marker of disease status in patients with visceral leishmaniasis in ethiopia. [PDF]

, 2013
The underlying mechanisms resulting in the profound immune suppression characteristic of human visceral leishmaniasis (VL) are not fully understood. Here, we tested the hypothesis that arginase, an enzyme associated with immunosuppression, is higher in ...
Corset, C, Cloke Tom, Closs Ellen, Cloke, T, Yifru Sisay, Abebe Tamrat, Corset, M, Modolell, M, Takele, Yegnasew, Corware, Karina, Cloke, Tom, Sisay Yifru, Hailu, Workagegnehu, Munder, M, Tacchini-Cottier, F, Ingrid Müller, Kropf, P, Müller, Ingrid, Markus Munder, Weldegebreal, T, Weldegebreal Teklu, Teklu Weldegebreal, Closs, E, Sisay, Y, Hailu, W, Mueller, I, Pascale Kropf, Camille Corset, Müller Ingrid, Sisay, Yifru, Takele Yegnasew, Closs, Ellen, Karina Corware, Weldegebreal, Teklu, Modolell, Manuel, Corware, K, Asrat Hailu, Corware Karina, Abebe, T, Corset Margaux, Munder, Markus, Manuel Modolell, Hailu Workagegnehu, Hailu, A, Margaux Corset, Modolell Manuel, Workagegnehu Hailu, Kropf Pascale, Abebe, Tamrat, Tacchini-Cottier, Fabienne, Fabienne Tacchini-Cottier, Yegnasew Takele, Kropf, Pascale, Corset Camille, Munder Markus, Tom Cloke, Corset, Margaux, Ellen Closs, Tacchini-Cottier Fabienne, Hailu Asrat, Corset, Camille, Hailu, Asrat, Takele, Y, Tamrat Abebe   +63 more
core   +1 more source

Expandable Nanocomposite Shape‐Memory Hemostat for the Treatment of Noncompressible Hemorrhage

Advanced Science, Volume 13, Issue 23, 23 April 2026.
A nanocomposite‐coated shape memory foam rapidly expands, accelerates clotting, and reduces blood loss in vivo. Its fast volumetric expansion and strong procoagulant activity make it a promising hemostat for treating deep, noncompressible hemorrhage.
Saptarshi Biswas, Sarah E. Miller, Shounak Roy, Jeevika Thazhaiselvam, Samantha Foster, Manivannan Sivaperuman Kalairaj, Sasha M. George, Yava Jones‐Hall, Staci J. Horn, Fred J. Clubb, Taylor H. Ware, Duncan J. Maitland, Akhilesh K. Gaharwar   +12 more
wiley   +1 more source

Assessing aquaglyceroporin gene status and expression profile in antimony-susceptible and -resistant clinical isolates of Leishmania donovani from India [PDF]

, 2010
Objectives: Clinical resistance to pentavalent antimonials results from an interplay between uptake, efflux and sequestration in Leishmania. Aquaglyceroporins (AQPs) have been shown to facilitate uptake of trivalent metalloids. Down-regulation of AQP1 in
Singh, Sarman, Maharjan, Mahendra, Mandal, Swati, Chatterjee, Mitali, Madhubala, Rentala   +4 more
core   +1 more source

Respiratory‐Limbic Coupling via a Thalamic Circuit Alleviates Anxiety

Advanced Science, Volume 13, Issue 24, 27 April 2026.
This study delineates a conserved preBötCGlu→PVT→CeA circuit that gates anxiety and respiration. Activation of this circuit is anxiolytic and respiratory‐stabilizing, while its inhibition has the opposite effect. Mechanistically, PVT exerts its anxiolytic action via a disinhibitory microcircuit: its inputs preferentially target CeL GABAergic neurons ...
Shangyu Bi, Xiaoyi Wang, Huichun Luo, Ziteng Yue, Tianjiao Deng, Yuhang Liu, Xinxin Chen, Jianxu Zhao, Luo Shi, Ning Ma, Lingyan Mao, Jing Ding, Jiwen Xu, Ti‐Fei Yuan, Sheng Wang, Fang Yuan   +15 more
wiley   +1 more source

Sub-Optimal dose of Sodium Antimony Gluconate (SAG)-Diperoxovanadate Combination Clears Organ Parasites from BALB/c Mice Infected with Antimony Resistant Leishmania Donovani by Expanding Antileishmanial T-Cell Repertoire and Increasing IFN-c to IL-10 Ratio

, 2009
We demonstrate that the combination of sub-optimal doses of Sodium Antimony Gluconate (SAG) and the diperoxovanadate compound K[VO(O2)2(H2O)], also designated as PV6, is highly effective in combating experimental infection of BALB/c mice with antimony ...
Syamal Roy, Kshudiram Naskar, Diganta Kalita, Islam, Nashreen S, Arun Kumar Haldar, Kalita, Diganta, Roy, Syamal, Nashreen S. Islam, Haldar, Arun Kumar, Naskar, Kshudiram, Subha Banerjee, Banerjee, Subha   +11 more
core   +1 more source