Results 151 to 160 of about 2,821 (202)
Some of the next articles are maybe not open access.
Expert Review of Clinical Pharmacology, 2010
Many commonly prescribed medications have antimuscarinic side effects. These can be severe and disabling, but it is not always possible to predict which patients will suffer these effects. The development of practical tools that predict the likelihood of adverse drug reactions would aid rational prescribing, thereby improving patient safety and ...
Soiza, Roy L +2 more
openaire +3 more sources
Many commonly prescribed medications have antimuscarinic side effects. These can be severe and disabling, but it is not always possible to predict which patients will suffer these effects. The development of practical tools that predict the likelihood of adverse drug reactions would aid rational prescribing, thereby improving patient safety and ...
Soiza, Roy L +2 more
openaire +3 more sources
The Q-T interval and antimuscarinic drugs
Current Bladder Dysfunction Reports, 2005Antimuscarinic drugs form the mainstay of pharmacotherapy for the treatment of overactive bladder. The primary sites of activity of the agents for the desired therapeutic effect are the M3 and M2 receptors of the bladder. Drug interaction with other non-vesical muscarinic receptors produces a range of undesired adverse events.
Roger, Dmochowski, David R, Staskin
openaire +2 more sources
Antimuscarinic management of overactive bladder
British Journal of Community Nursing, 2005The symptoms of an overactive bladder (OAB) has a negative effect on the health-related quality of life of a sufferer. Many do not seek help and up to 73% of those of who are assessed do not take medication to relieve their symptoms. The key to managing this condition is a multidisciplinary approach to conservative behaviour therapy in the form of ...
openaire +2 more sources
Antimuscarinics for treatment of overactive bladder
The Lancet Neurology, 2004For many years, antimuscarinic drugs have been the first-line pharmacological treatment for urgency, frequency, and urge incontinence, all symptoms of the disorder termed overactive bladder. Antimuscarinic treatment is not always effective and is associated with side-effects that limit its clinical use.
openaire +2 more sources
Antimuscarinic Agents as Substances of Abuse
Journal of Clinical Psychopharmacology, 1988Centrally active antimuscarinic agents are generally used in psychiatry to treat the extrapyramidal side effects of antipsychotic medications. However, these agents may have antidepressant and mood-elevating properties, and the literature suggests they are liable to abuse. The author reviews this literature and discusses its implication.
openaire +2 more sources
Desethylaprophen: A Metabolite of Aprophen with Antimuscarinic Activities*
Journal of Pharmaceutical Sciences, 1988The metabolic fate of aprophen hydrochloride (2-diethylaminoethyl 2,2-diphenylpropionate) was studied in rats after intravenous administration. Both 14C-labeled and unlabeled aprophen were used in these studies. Blood samples were collected and analyzed to determine the identities of the metabolites formed.
N D, Brown +4 more
openaire +2 more sources
Total synthesis of antimuscarinic alkaloid, (±)-TAN1251A
Tetrahedron, 2002Abstract The total synthesis of (±)-TAN1251A possessing an antimuscarinic activity was achieved. Carboxylic acid ( 1 ) was converted into carbamate ( 3 ) through a sequence of alkylation and Curtius rearrangement. After a few functional group interconversions of 3 , the corresponding amine ( 9 ) was converted into an azaspiro molecule ( 18
Shinji Nagumo +5 more
openaire +1 more source
Preferences for antimuscarinic therapy for overactive bladder
BJU International, 2010Study Type – Preference (discrete choice experiment) Level of Evidence 2a What’s known on the subject? and What does the study add? Whilst antimuscarinic treatments are widely used little work has been done to understand how patients consider the relative ...
Paul, Swinburn +5 more
openaire +2 more sources
Antimuscarinic drugs to treat overactive bladder
BMJ, 2012A 45 year old woman presents to her general practitioner complaining of troublesome urinary symptoms increasingly affecting her quality of life. She is currently voiding more than 10 times a day and rising three times at night. In addition she notices a sudden urgent desire to void and on two occasions has leaked urine before reaching the toilet.
Dudley, Robinson, Linda, Cardozo
openaire +2 more sources
Methods and findings in experimental and clinical pharmacology, 1989
Anticholinergic, or antimuscarinic, drugs have been used for the treatment of more or less specified gastrointestinal diseases or complaints for many centuries, first in herbal preparations (including belladonna), and in modern times as synthetic tertiary or quaternary compounds, with atropine being a pharmacological standard.
openaire +1 more source
Anticholinergic, or antimuscarinic, drugs have been used for the treatment of more or less specified gastrointestinal diseases or complaints for many centuries, first in herbal preparations (including belladonna), and in modern times as synthetic tertiary or quaternary compounds, with atropine being a pharmacological standard.
openaire +1 more source