Results 71 to 80 of about 2,821 (202)

Exocrine Gland Dysfunction in Parkinson's Disease: Pathophysiology, Clinical Manifestations, and Therapeutic Perspectives—A Narrative Review

Movement Disorders Clinical Practice, Volume 13, Issue 9, Page 2081-2092, September 2026.
Abstract Background Non‐motor symptoms, especially autonomic dysfunction, are major contributors to disability and decreased quality of life in Parkinson's disease (PD). Despite being common and having a wide range of clinical facets, exocrine gland dysfunction is still not well recognized and managed.
Renato P. Munhoz, Marina Farah, Laura Silveira‐Moriyama   +2 more
wiley   +1 more source

Evaluation of the incidence and risk factors associated with persistent frequency in interstitial cystitis/bladder pain syndrome and the efficacy of antimuscarinic treatment [PDF]

Investigative and Clinical Urology, 2017
Purpose: To investigate the incidence and risk factors associated with persistent urinary frequency, and to evaluate the efficacy of antimuscarinic treatment.Materials and Methods: Interstitial cystitis/bladder pain syndrome (IC/BPS) patients complaining
Aram Kim, Kyeong-Ok Hoe, Jung Hyun Shin, Myung-Soo Choo   +3 more
doaj   +1 more source

The Neurovascular Niche: A Gathering Venue for Neuroinflammation and Remyelination in Multiple Sclerosis

Acta Physiologica, Volume 242, Issue 9, September 2026.
ABSTRACT In the central nervous system (CNS), the tissue microenvironment is continuously monitored and regulated to secure the unobstructed function of neurons and of their networks. This is a key function of the neurovascular niche (NVN), which is the interface between the cells of the nervous tissue and the cells and the content of blood vessels. It
Ilias Kazanis, Maria Elena Silva, Alerie G. de la Fuente, Fernando de Castro, Francisco J. Rivera   +4 more
wiley   +1 more source

Insights into the Management of Overactive Bladder with Transdermal Oxybutynin: A Practical Review

Research and Reports in Urology, 2020
Raúl Vozmediano-Chicharro,1 Pedro Blasco Hernández,2 Blanca Madurga-Patuel3 1Service of Urology, Hospital Universitario Carlos Haya, Universidad de Málaga, Málaga, Spain; 2Service of Urology, Hospital Universitario de Valme ...
Vozmediano-Chicharro R, Blasco Hernández P, Madurga-Patuel B   +2 more
doaj  

Acute Encephalopathy in a Patient With Chronic Isotretinoin Exposure and Frequent Rizatriptan Use: A Case Report

Clinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT Acute encephalopathy in patients with prolonged isotretinoin exposure should prompt careful assessment of undisclosed or non‐prescribed medication use. This case suggests a possible association between high cumulative isotretinoin exposure, frequent daily rizatriptan use, and acute encephalopathy, but does not establish a definitive drug–drug ...
Soheil Roshanzamiri, Mitra Rahimi, Shahin Shadnia, Peyman Erfantalab Evini, Faraz Zandiyeh, Babak Mostafazadeh   +5 more
wiley   +1 more source

Obstructive Sleep Apnea: Epidemiology, Pathophysiology, Complications, Diagnosis, Management, and Emerging Fibrosis‐Linked Remodeling

MedComm, Volume 7, Issue 8, August 2026.
Obstructive sleep apnea (OSA) is characterized by recurrent upper‐airway collapse, which generates key nocturnal stressors including intermittent hypoxia, sleep fragmentation, intrathoracic pressure stress, and sympathetic activation. These physiological disturbances converge on shared biological mechanisms, including oxidative stress, inflammation ...
Nhi Ho Thi Thuy, Thị Hằng Giang Phan, Ali Hussein Eid, Paola Maccioccu, Stefania Camboni, Gavino Casu, Anna Maria Posadino, Roberta Giordo, Gianfranco Pintus   +8 more
wiley   +1 more source

Antimuscarinics in older people: dry mouth and beyond

, 2016
Many common prescription and over-the-counter medications have antimuscarinic effects. Antimuscarinics are a well recognized cause of dry mouth, with potential to cause other physical and cognitive adverse effects. A comprehensive medication review in a
Clare Bostock, Christopher McDonald
core   +1 more source

In Vivo Evaluation of Psoralen in a Copper Sulfate–Induced Chick (Gallus gallus domesticus) Emesis Model and In Silico Analysis of Its Interaction With D2, 5‐HT3A, and Muscarinic Receptors

ChemistryOpen, Volume 15, Issue 8, August 2026.
Psoralen (PSN) demonstrates significant dose‐dependent antiemetic activity in a copper sulfate–induced chick emesis model. Integrated in vivo and in silico analyses reveal reduced retching frequency, prolonged latency, and favorable multi‐receptor interactions with D2, 5‐HT3A, and muscarinic receptors, highlighting PSN as a promising multi‐target ...
Kishor Chandra, Sharif Uddin Bahar, Khadija Akter, Mst Muslima Khatun, Samiran Sadhukhan, Progna Saha Puja, Fazley Rohan, Md Shimul Bhuia, Mohammed Alfaifi, Faisal H. Altemani, Faisal Alsenani, Salehin Sheikh, Muhammad Torequl Islam   +12 more
wiley   +1 more source

Additional file 3: of A retrospective study of treatment persistence and adherence to mirabegron versus antimuscarinics, for the treatment of overactive bladder in Spain

, 2018
Figure S2. Median TTD for mirabegron versus antimuscarinics (base-case analysis) in the following subgroups of patients: treatment-naïve (A); treatment-experienced (B);
Jameel Nazir (3831556), Amine Khemiri (5718845), Zalmai Hakimi (3831568), Florent Guelfucci (4041191), Francis Fatoye (3831565), Marta González (5718857), Ana Blázquez (5718851)   +6 more
core   +1 more source

Clinical and economic impact of mirabegron compared with antimuscarinics for the treatment of overactive bladder in Canada

, 2017
Background: The β3-adrenoceptor agonist, mirabegron, and antimuscarinic agents provide similar efficacy for the treatment of overactive bladder (OAB), but mirabegron appears to be associated with better persistence, perhaps due to an absence of ...
Jameel Nazir (3831556), Zalmai Hakimi (3831568), Malin Berling (3831553), Adrian Wagg (3627275), Francis Fatoye (3831565), Barbara Ramos (3831562), Charles McCrea (3831559)   +6 more
core   +1 more source