Results 91 to 100 of about 22,860 (171)

Flometoquin, a novel insecticide, acts on mitochondrial complex III as a Q_i inhibitor. [PDF]

J Pestic Sci
Takeuchi H, Nomura M, Horikoshi R, Aasano S, Miyake T, Kobayashi T, Murai M, Chen YJ, Earley F, Mina J, Crossthwaite A.   +10 more
europepmc   +1 more source

The Gut Microbial Metabolite Butyrate Alleviates IL‐1β‐Induced Mitochondrial Dysfunction and Oxidative Stress in Pancreatic Islets

The FASEB Journal, Volume 39, Issue 11, 15 June 2025.
Butyrate, a gut microbiota‐derived metabolite, protects pancreatic beta cells from interleukin‐1beta (IL‐1β)‐induced dysfunction. In a model of low‐grade inflammation using long‐term, non‐cytotoxic IL‐1β stimulation, butyrate enhanced mitochondrial function, promoted hyperfusion, and reduced mitochondrial fragmentation in mouse pancreatic islets ...
Signe Schultz Pedersen, Richard Denis Maxime De Mets, Joana Mendes Lopes de Melo, Andrea Irazoki, Patrick E. MacDonald, Michala Prause, Nils Billestrup   +6 more
wiley   +1 more source

Multiple Inhibitory Mechanisms of DS16570511 Targeting Mitochondrial Calcium Uptake: Insights from Biochemical Analysis of Rat Liver Mitochondria. [PDF]

Int J Mol Sci
Yamada A, Watanabe A, Nara A, Inokuma T, Asano M, Shinohara Y, Yamamoto T.   +6 more
europepmc   +1 more source

The effect of trimetazidine on cardiac haemodynamics and mitochondrial function in wild‐type transthyretin amyloidosis

ESC Heart Failure, Volume 12, Issue 3, Page 1796-1806, June 2025.
Abstract Aims Wild‐type transthyretin cardiac amyloidosis (ATTRwt) is a cardiomyopathy causing myocardial hypoperfusion and impaired cardiac mitochondrial function. Trimetazidine is an antianginal agent used in patients with stable angina pectoris, which improves cardiac contractility and mitochondrial function.
Bertil Thyrsted Ladefoged, Anders Lehmann Dahl Pedersen, Anne Mette Dybro, Tor Skibsted Clemmensen, Julian Gillmore, Steen Hvitfeldt Poulsen   +5 more
wiley   +1 more source

Sub-organellar mitochondrial hydrogen peroxide observed using a SNAP tag targeted coumarin-based fluorescent reporter. [PDF]

Redox Biol
Eaglesfield R, Fernandez-Vizarra E, Lacko E, Caldwell ST, Sloan NL, Siciarz D, Hartley RC, Tokatlidis K.   +7 more
europepmc   +1 more source

The Ancient Drug Salicylate Indirectly Targets Fructose‐1,6‐Bisphosphatase to Suppress Liver Glucose Production in Diet‐Induced Obese Mice

Acta Physiologica, Volume 241, Issue 6, June 2025.
ABSTRACT Aims The benefit of salicylate in the treatment of diabetes has been recognized for over a century; however, challenging side effects have prevented widespread use. A better understanding of the relevant enzyme targets mediating its anti‐hyperglycaemic effect may lead to the development of novel therapies for diabetes.
Raid B. Nisr, Abdelmadjid Atrih, Erika J. Gutierrez Lara, Douglas Lamont, Katarzyna M. Luda, Rory J. McCrimmon, Kei Sakamoto, Graham Rena, Alison D. McNeilly   +8 more
wiley   +1 more source

Acute Metabolic Stress Induces Lymphatic Dysfunction Through KATP Channel Activation. [PDF]

Function (Oxf)
Kim HJ, Norton CE, Zawieja SD, Castorena-Gonzalez JA, Davis MJ.   +4 more
europepmc   +1 more source

Exosomal PKM2: A Noninvasive Diagnostic Marker Linking Macrophage Metabolic Reprogramming to Gastric Cancer Pathogenesis

Cancer Science, Volume 116, Issue 6, Page 1537-1549, June 2025.
Plasma exosomal PKM2 is a promising novel biomarker for early gastric cancer diagnosis. It activates the SREBP1‐mediated lipid synthesis pathway in macrophages, promoting their alternative activation and thereby driving tumor progression. ABSTRACT Tumor‐derived exosomes (TDEs) have emerged as vital biomarkers of multiple cancers.
Mengyun Yuan, Xiaoxia Zheng, Shanshan Zheng, Huaizhi Li, Xingxing Zhang, Yuxuan Chen, Xiang Zhang, Bo Han, Wei Wei, Jian Wu, Qingmin Sun   +10 more
wiley   +1 more source

Strain variation in Candida albicans glycolytic gene regulation. [PDF]

mSphere
Kim M-J, White AM, Mitchell AP.
europepmc   +1 more source

PTPN2 Negatively Regulates Macrophage Immune Responses and Cellular Bioenergetics

The FASEB Journal, Volume 39, Issue 9, 15 May 2025.
It is the deletion that upregulates phosphorylation of STAT1 and STAT3, coinciding with a modulation of several genes involved in immune responses and metabolism. These lead to the Warburg effect, characterized by a decrease in mitochondrial respiration and an increase in glycolysis, in proinflammatory macrophages lacking TC‐PTP. These macrophages also
Valerie Vinette, Yevgen Zolotarov, Alexandre Poirier, Zuzet Martinez Cordova, Isabelle Aubry, Michel L. Tremblay   +5 more
wiley   +1 more source