Results 201 to 210 of about 21,172,428 (334)

Deficiency of Microglial‐Derived Spp1 Exacerbates Age‐Related Memory Decline by Impairing Mitochondrial Complex I Function

open access: yesAging Cell, Volume 25, Issue 2, February 2026.
Microglia‐derived Spp1 regulates OXPHOS via the AKT/Complex I pathway to mitigate age‐related memory decline. (Graphical Abstract was created using BioRender). ABSTRACT Age‐related memory decline is a hallmark of brain aging and a primary risk factor for neurodegenerative disorders.
Meiling Wang   +9 more
wiley   +1 more source

EFFECT OF DIET ON THE ANTIMYCIN TITER OF MOUSE LIVER

open access: hybrid, 1954
Arnold E. Reif   +4 more
openalex   +1 more source

Dietary Protein Restriction Ameliorates Cardiac Inflammaging via AMPK‐ULK1‐Mediated Mitochondrial Quality Control

open access: yesAging Cell, Volume 25, Issue 2, February 2026.
Dietary protein restriction protects the aging heart in the context of obesity by limiting mitochondrial DNA leakage and suppressing cGAS–STING‐driven inflammation. Through AMPK–ULK1‐dependent mitophagy, protein restriction restores mitochondrial quality control, reduces cardiac remodeling, and preserves metabolic homeostasis during obesity‐associated ...
Wagner S. Dantas   +8 more
wiley   +1 more source

Blood Cell Mitochondrial Respiration Increases With Age and Varies by Sex in Healthy Adults

open access: yesAging Cell, Volume 25, Issue 2, February 2026.
Using samples from the San Diego Nathan Shock Center Clinical Cohort, we found that blood cell bioenergetic capacity is generally positively associated with age and sex dependent. These findings highlight the importance of biological context in bioenergetics research. Created in BioRender. Lab, M. (2025) https://BioRender.com/pvgt48f.
Howard J. Phang   +9 more
wiley   +1 more source

Regional metabolic analysis of structurally preserved kidney slices by ex vivo respirometry. [PDF]

open access: yesAm J Physiol Renal Physiol
Bessho R   +3 more
europepmc   +1 more source

Disruption of ATP Synthase Spatiotemporal Organization, Ca2+ Dynamics, and Contractile Function in Senescent Cardiomyocytes

open access: yesAging Cell, Volume 25, Issue 2, February 2026.
Enhanced ATP hydrolysis, ΔΨm flickering, and destabilized ATP synthase dimers collectively reduce ATP availability in senescent cardiomyocytes. This energy deficit is associated with disrupted Ca2⁺ dynamics and contractility. ABSTRACT Heart disease is the leading cause of death in the elderly population.
Silke Morris   +9 more
wiley   +1 more source

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