Results 231 to 240 of about 21,172,428 (334)

Intestinal Neutral Ceramidase Deficiency Triggers Regulatory T Cell Response via Gd3 to Protect the Host from Intestinal Inflammation

open access: yesAdvanced Science, Volume 13, Issue 5, 27 January 2026.
Deletion of ASAH2 in intestinal epithelial cells induces the accumulation of ganglioside GD3 via regulating ST8SIA1. GD3 is identified as the glycolipid ligand for the inhibitory receptor Siglec‐E on macrophages. GD3/Siglec‐E ligation polarizes macrophages and promotes the proliferation of colonic ST2+ T regulatory cells via the induction of IL‐33. The
Zhishan Xu   +11 more
wiley   +1 more source

Kitamycin C, a new antimycin-type antibiotic from Streptomyces antibioticus strain 200-09

open access: green, 2017
Fan Wang   +6 more
openalex   +2 more sources

Puerarin Targets MIC19 to Suppress Mitochondrial Metabolism of Tumor‐Infiltrating Tregs and Enhance Anti‐tumor Immunity

open access: yesAdvanced Science, Volume 13, Issue 4, 19 January 2026.
Puerarin targets mitochondrial MIC19 in tumor‐infiltrating Tregs, impairing their immunosuppressive function and enhancing antitumor immunity. This study uncovers the metabolic dependency of tumor‐infiltrating Tregs and highlights a potential metabolic‐targeted immunotherapeutic strategy for liver cancer. Abstract Regulatory T cells (Tregs) are pivotal
Yu Li   +10 more
wiley   +1 more source

Stromal Cell‐Mast Cell Communication Orchestrates Anti‐Viral Immunity in the Meninges

open access: yesAdvanced Science, Volume 13, Issue 5, 27 January 2026.
This study delineates the spatial distribution and postnatal maturation of meningeal mast cells and uncovers their essential role in antiviral immunity. Using genetic models, mast cells are shown to promote CD8⁺ T cell infiltration and viral clearance via IL‐33 receptor signaling and synergistic activation by IL‐33 and ATP from infected stromal cells ...
Qingqing Li   +7 more
wiley   +1 more source

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