Results 171 to 180 of about 13,105 (210)

Cancer Heterogeneity and Cancer Cell Plasticity: Molecular Mechanisms and Precision Therapy

MedComm, Volume 7, Issue 7, July 2026.
Tumor progression is driven by heterogeneity occurring across multiple biological scales. At the molecular level, tumor cells exhibit alterations across distinct omics layers, including genomic mutations, epigenomic reprogramming, transcriptional changes, and proteomic remodeling, collectively shaping tumor cell phenotypes and functional states.
Hanwen Hu, Zhixing Hao, Lili Li, Huiying Liu, Chenghui Yang, Zhen Wang   +5 more
wiley   +1 more source

Problems associated with the ATC system of drug classification. [PDF]

Naunyn Schmiedebergs Arch Pharmacol
Bindel LJ, Seifert R.
europepmc   +1 more source

The Multifaceted Role of Pyroptosis: Molecular Mechanisms, Crosstalk with Other Cell Death Pathways, and Therapeutic Implications

MedComm, Volume 7, Issue 7, July 2026.
Pyroptosis maintains immune homeostasis by eliminating damaged or infected cells, but its dysregulation promotes inflammation and cancer progression. The diagram illustrates key activation pathways, links with other programmed cell deaths, and cancer‐specific effects, enhancing its dual protective and pathogenic roles.
Diego Liviu Boaru, Patricia De Castro‐Martinez, Cielo Garcia‐Montero, Oscar Fraile‐Martinez, Majd N. Michael Alhaddadin, Silvestra Barrena‐Blázquez, Laura Lopez‐Gonzalez, Clara Tasende Fernández, Ricardo Alvarado‐Hurtado, Tomás Ratia Giménez, Inmaculada Lasa‐Unzúe, Manuel Díez Alonso, Alberto Gutiérrez‐Calvo, Miguel A. Saez, David Cobo‐Prieto, Jose V. Saz, Melchor Alvarez‐Mon, Raul Diaz‐Pedrero, Miguel A. Ortega   +18 more
wiley   +1 more source

Docetaxel versus androgen receptor pathway inhibitors as first-line therapy for metastatic castration-resistant prostate cancer after doublet therapy: a multicenter retrospective study from Saudi Arabia. [PDF]

BMC Urol
Bazarbashi S, Abdelmotal AS, Arabi T, Fallatah W, Alzannan N, Elhassan T, Aseafan M, Mahroos M, Aljishi M, Busbaih A, Aldandan R, Rauf MS, Almugbel FA, Azam F, Almansour M.   +14 more
europepmc   +1 more source

Endometriosis: Epidemiology, Risk Factors, Molecular Mechanisms, Diagnosis, and Management

MedComm, Volume 7, Issue 7, July 2026.
Global epidemiology, integrated determinants, and disease burden of endometriosis. This circular schematic comprehensively illustrates the global prevalence and demographic variation of endometriosis, its multifactorial integrated determinants, the multifaceted disease burden and economic impact, and recent epidemiological trends, providing a holistic ...
Kun Wang, Dongyun He, Yang Wang, Xiaojun Liu, Li Liu   +4 more
wiley   +1 more source

Predicting response to neoadjuvant hormonal therapy and prognostic outcomes in high-risk prostate cancer using MRI-based radiomics. [PDF]

BMC Cancer
Zhou H, Qian ZY, Chen ZH, Fan JJ, Mao YX, Xu LY, He YJ, Zhang JX, Wu JH, Sheng L.   +9 more
europepmc   +1 more source

Epoxy Clerodane Diterpene Attenuates the Differentiated Adipocyte Hypertrophy and Enhances Mitochondrial Metabolism

ChemistryOpen, Volume 15, Issue 7, July 2026.
Epoxy Clerodane Diterpene (ECD) significantly reduces adipocyte hypertrophy and lipid accumulation in human mesenchymal stem cell (hMSC)‐derived adipocytes. ECD improves mitochondrial membrane potential (ΔΨm), increases thermogenic regulators (UCP‐1, PPARγC1α), decreases adipogenic markers (C/EBPα, PPARγ), and reduces inflammatory mediators (TNF‐α, NF ...
Sahar Abdulaziz AlSedairy, Pandurangan Subash‐Babu, Maha H. Alhussain, Manal Abdulaziz Binobead, Ali A. Alshatwi   +4 more
wiley   +1 more source

Time series analysis of the new tiering pricing policy for generic medicines in South Korea. [PDF]

Front Pharmacol
Park CM, Song I, Kim DS.
europepmc   +1 more source

Drug-associated insomnia: A pharmacovigilance study based on FDA adverse event reporting system. [PDF]

Medicine (Baltimore)
Huang X, Chen Y, Li S, Wen Y, Liu H, Cao G.   +5 more
europepmc   +1 more source