Results 191 to 200 of about 17,757 (259)

A Feasibility Study of the Repurposing of Prazosin to Improve Treatment Outcomes in Men Receiving Radiotherapy for Prostate Cancer (MiniRaP‐00)

The Prostate, Volume 86, Issue 8, Page 891-899, June 2026.
ABSTRACT Background Further work is needed to improve treatment outcomes for prostate cancer (PCa), with the repurposing of the α1‐adrenoreceptor antagonists presenting a potential solution. This feasibility clinical trial presents the first prospective data of the use of an α1‐adrenoreceptor antagonist in men undergoing radiotherapy for PCa.
Liam D. King, David Christie, Daniel Cehic, Wendy Dare, Russ Chess‐Williams, Donna Sellers, Catherine McDermott, Alexandra McCarthy, Shailendra Anoopkumar‐Dukie   +8 more
wiley   +1 more source

Successful treatment of large-cell neuroendocrine carcinoma of the prostate with pembrolizumab: a case report. [PDF]

J Med Case Rep
Yamashita E, Ashida S, Yoshimura R, Iga R, Kurano Y, Yamamoto S, Shimamoto T, Fukuhara H, Fukata S, Kurabayashi A, Karashima T, Inoue K.   +11 more
europepmc   +1 more source

Synergistic RU486 and olaparib therapy enhances apoptosis in endometriosis by simultaneously targeting hormonal signalling and DNA repair

British Journal of Pharmacology, Volume 183, Issue 11, Page 2947-2968, June 2026.
Background and Purpose Endometriosis is a chronic, hormone‐dependent disorder characterized by ectopic implantation of endometrial tissue, often accompanied by pain and infertility. Although the progesterone receptor modulator RU486 is effective for pain relief, its impact on lesion regression is limited, possibly due to apoptosis resistance and ...
Yujie Peng, Meng Zhang, Libo Zhu, Wenqiang Qian, Jingjing Yan, Huidi Jiang, Yu Xin, Ying Zhang, Dongli Sun, Weidong Fei, Mengdan Zhao   +10 more
wiley   +1 more source

Therapeutic Strategies for Abdominal Aortic Aneurysm: A Comprehensive Systematic Review. [PDF]

J Cardiovasc Dev Dis
Kavaliunaite E, Sejr Skovbo Kristensen J, Scheurer S, Berg I, Lindholt JS, Stubbe J.   +5 more
europepmc   +1 more source

Immunotherapy in advanced gastroesophageal cancers: A meta‐analysis of sex‐based outcomes in overall survival

International Journal of Cancer, Volume 158, Issue 10, Page 2697-2708, 15 May 2026.
What's New? Immune checkpoint inhibitors (ICIs) improve survival in advanced gastroesophageal cancer (GEC), but their benefits may differ by sex. Little is known, however about the impact of sex‐related immune differences on ICI efficacy. In this meta‐analysis, sex‐specific outcomes of ICI therapy were evaluated in advanced GEC, encompassing both ...
Michael Masetti, Fausto Petrelli, Filippo Pietrantonio, Sylvie Lorenzen, Alberto Giovanni Leone   +4 more
wiley   +1 more source

Signal stratification of antineoplastic drugs associated with interstitial lung disease: A multi-method signal detection analysis using the FAERS database. [PDF]

Medicine (Baltimore)
Gong Z, Wang Q, Huang Y, Xu H.
europepmc   +1 more source

Synthesis of Amines for Active Pharmaceutical Ingredients Using the Whole‐Cell Factory Saccharomyces Cerevisae

ChemBioChem, Volume 27, Issue 9, 14 May 2026.
This review highlights advances in engineering Saccharomyces cerevisiae for the sustainable biocatalytic production of pharmaceutically relevant amines, amino alcohols, amino acids, and complex alkaloids. It focuses on strategies to increase productivity, including enhanced enzyme expression, cofactor regeneration, precursor channeling, pathway ...
Natalia Kwiatos, Stephen Ossel, Francesco G. Mutti   +2 more
wiley   +1 more source

Pharmacovigilance insights into drug-associated venous thromboembolism. [PDF]

Int J Surg
Cai X, Chen G, Wang H, Wang L, Hu C.
europepmc   +1 more source

Triple‐Negative Breast Cancer Versus Non‐Triple‐Negative Breast Cancer: The Impact of Pd and Pt Complexes on Basal‐Like Triple‐Negative Breast Cancer

ChemMedChem, Volume 21, Issue 9, 14 May 2026.
The anticancer activity of the complexes Pd3Spd2, Pt3Spd2, Pt2Put2(NH3)4 and Pd2Put2 against human TNBC, non‐TNBC and healthy breast cells was evaluated. The metabolic impact of the most promising metal complexes—Pd3Spd2 and Pt2Put2(NH3)4—was further assessed using vibrational microspectroscopies, providing detailed insights into the drug‐induced ...
Clara B. Martins, Maria P. M. Marques, Luís A. E. Batista de Carvalho, Ana L. M. Batista de Carvalho   +3 more
wiley   +1 more source

The impact of androgen deprivation therapy and novel hormonal therapy on thyroid hormone levels in prostate cancer patients: a systematic review and meta-analysis. [PDF]

World J Surg Oncol
Chu H, Qu Y.
europepmc   +1 more source