Results 201 to 210 of about 1,663,582 (244)

Signal detection of drug-induced esophageal ulcer across 20 years of real-world study: Focus on 49 high-risk medicines. [PDF]

J Int Med Res
Zheng W, Jin LY, Hu J, Wang JY, Mao KL, Jiang Q.   +5 more
europepmc   +1 more source

Comprehensive In Silico Analysis Identifies MSTO1 and LIG1 as Candidate Biomarkers With Diagnostic and Prognostic Relevance in Hepatocellular Carcinoma

Cancer Reports, Volume 9, Issue 9, September 2026.
ABSTRACT Background Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and remains a major cause of cancer‐related mortality worldwide. Its poor clinical outcomes are largely attributed to late‐stage diagnosis and the limited accuracy of currently available diagnostic and prognostic biomarkers.
Jana Hamad, Hussein Fayyad‐Kazan, Fadi Abdel‐Sater   +2 more
wiley   +1 more source

Trends in Medicines Discontinuation and Implications for Access in Brazil (2014-2024). [PDF]

Pharmacoepidemiol Drug Saf
de Lima ROM, Silva ER, Emmerick ICM, de Souza Serio Dos Santos DM, Godói IPD, Campos ACV, Chaves LA.   +6 more
europepmc   +1 more source

The Roles of EETs in Neurological Disorders

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
Epoxyeicosatrienoic acids (EETs), derived from arachidonic acid (ARA) via cytochrome P450 (CYP450) enzymes, are produced in nearly all human tissues and exert a wide range of beneficial effects. This review summarizes the roles and potential mechanisms of EETs in neurological disorders, with a focus on cerebrovascular diseases, epilepsy, Parkinson's ...
Rong Tang, Mengya Li, Banglian Hu, Guoqiang Fei, Honghua Zheng, Xin Wang, Jing Ding   +6 more
wiley   +1 more source

Targeting tumor-associated G-protein coupled receptors: beyond single-axis inhibition toward multidimensional regulation. [PDF]

Cell Oncol (Dordr)
Zhou X, Tan B, Zhang T, Liu W, Zuo Y, Ren B, Wang T, Li L, Chen S, Lu J.   +9 more
europepmc   +1 more source

Payload‐Based Clinical Pharmacology Review of Approved Antibody–Drug Conjugates: Commonalities and Considerations for Streamlined Development

Clinical Pharmacology &Therapeutics, Volume 120, Issue 3, Page 614-638, September 2026.
Antibody–drug conjugates (ADCs) combine the specificity of an antibody with the potency of a cytotoxic drug. Thirteen ADCs, utilizing seven unique cytotoxic payloads and targeting 11 distinct antigens, are currently approved by the US Food and Drug Administration as of June 2025, representing a rapidly growing and highly promising class of anticancer ...
Sijie Lu, Qingqing Xiao, Lixuan Qian, Siyuan Sun, Zhu Zhou, Michael Z. Liao, Chunze Li   +6 more
wiley   +1 more source

Stratification system for pharmaceutical care in cancer patients: Chinese expert consensus. [PDF]

Front Pharmacol
Chen Y, Ma X, Lin M, Hu Z, Zhou J, Qiu Y, Liu Z, Du S, Shi L, Han L, Chen Y, Qi T, Zhang Y, Li G, Xiao H.   +14 more
europepmc   +1 more source

Cancer cell‐selective ectopic expression of CD20 as an antigen enables rituximab repurposing for solid tumour immunotherapy

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
A recombinant AAV delivered tumour gene therapy. NF‐κB drives tumour‐selective antigen (e.g., CD20) expression. Ectopic CD20 enables rituximab repurposing to solid tumours. ADCC, ADCP, and CDC contribute to the antitumour activity. Abstract Background Despite the clinical success of cancer immunotherapies, their efficacy is often compromised by antigen‐
Ziyan Kong, Yile Wang, Yunqi Zhao, Lu Wang, Zhimin Fan, Yongqian Shu, Jinke Wang   +6 more
wiley   +1 more source

Investigation of Adverse Events Associated with Predicted GnRHR Agonists Using the FAERS Database. [PDF]

Int J Mol Sci
Migura Y, Uesawa Y.
europepmc   +1 more source

Tryptophan metabolism in colorectal cancer: From mechanistic insights to novel therapeutic strategies

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
Tryptophan metabolism modulates CRC via three microbiota‐regulated pathways with distinct dual‐mode effects. The kynurenine pathway provides biomarkers, serotonin pathway supports SSRI‐combined immunotherapy, indole pathway yields immunostimulatory metabolites, collectively offering translational prospects.
Ran Wang, Wenke Shen, Ping Yang, Dongxue Yang, Yuepeng Cao, Yuping Zhou   +5 more
wiley   +1 more source