Results 131 to 140 of about 3,462,732 (382)

Synergistic Effect of Angelica gigas and Saccharin on Antiproliferative Activity in Ovcar-3 Cells

Korean Journal of Clinical Laboratory Science
Many patients with ovarian epithelial cancer, which accounts for more than 90% of ovarian cancers, are resistant to chemotherapy. Accordingly, Eastern medicine, which uses natural products as medicines, has been proposed.
Sang Yong PARK, Yu Jin PARK, Min-Woo LEE, Ji Hye HEO, Dong-Gil KIM, Suhng Wook KIM   +5 more
doaj   +1 more source

Adherence to Therapy With Oral Antineoplastic Agents [PDF]

, 2002
Ann H. Partridge
openalex   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Antineoplastic agents 285. Isolation and structures of cephalostatins 14 and 15 [PDF]

, 1994
George R. Pettit, Jun‐Ping Xu, Yoshitatsu Ichihara, Michael D. Williams, Michael R. Boyd   +4 more
openalex   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Procjena genotoksičnosti bleomicina i mitomicina C metodom kometnog testa [PDF]

, 2004
Although chemotherapy targets cancer tissue, it also damages the DNA of non-cancer cells. The aim of this study was to evaluate the in vitro genotoxic potential of therapeutic concentrations of bleomycin and mitomycin C, added alone or in combination to ...
Mirta Milić, Nevenka Kopjar
core   +1 more source

Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival

FEBS Open Bio, EarlyView.
Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel, Caroline Wozniak, Aya Sabri, Ben Haddad, Brooke Lopo, Alvaro Cobos, Sarah Sarofim, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans   +9 more
wiley   +1 more source

Effects of antineoplastic and immunomodulating agents on postvaccination SARS-CoV-2 breakthrough infections, antibody response, and serological cytokine profile

Journal for ImmunoTherapy of Cancer
Background Despite immunization, patients on antineoplastic and immunomodulating agents have a heightened risk of COVID-19 infection. However, accurately attributing this risk to specific medications remains challenging.Methods An observational cohort ...
Ki Suk Eum, Allison Martin, Michael Quigley, Jason Cham, Jacob New, Lana Smith, Leah Puglisi, Tridu Huynh, Sunil Kurian, Samantha Bagsic, Russel Fielding, Lee Hong, Priya Reddy, Bethany Barrick, Christopher Marsh, Laura J Nicholson, Amitabh C Pandey   +16 more
doaj   +1 more source

Aerosolization of nanotherapeutics as a newly emerging treatment regimen for peritoneal carcinomatosis

, 2019
Recent advances in locoregional chemotherapy have opened the door to new approaches for the clinical management of peritoneal carcinomatosis (PC) by facilitating the delivery of anti-neoplastic agents directly to the tumor site, while mitigating adverse ...
Ceelen, Wim, De Smedt, Stefaan, Remaut, Katrien, Shariati, Molood, Willaert, Wouter   +4 more
core   +1 more source

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source